<p>The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation</p>

Abstract

Objective: The present study was designed to evaluate the anti-inflammatory effects of different doses of aliskiren in two animal models of inflammation. Methodology: Sixty-six Wistar rats were allocated into five groups: the first group (six rats) was treated with the vehicle only, without induction of paw edema and granulomatous inflammation, and served as a negative control; the second group (12 rats) was allocated into two subgroups and treated with the vehicle only, with induction of paw edema and granulomatous inflammation, and served as a positive control; the third group (36 rats) was allocated into six subgroups and treated with different doses of aliskiren (15, 30, and 60 mg/kg) in both models; the fourth group (12 rats) was treated with dexamethasone (1 mg/kg) in both models of inflammation. Serum concentrations of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), vascular cell adhesion molecule-1 (VCAM-1), and high sensitivity C-reactive protein (hs-CRP) were measured. Skin samples were also sent for histopathological examination. Results: Aliskiren, in a dose-dependent pattern, significantly decreased inflammation in rat models of inflammation, by attenuating the percentage of exudate, granuloma, and paw edema. Furthermore, it significantly reduced serum concentrations of TNF-α, VCAM-1, and hs-CRP and restored the serum concentration of IL-10. Additionally, significant improvement was seen in the histopathological findings. Conclusion: In the current study, aliskiren was successful in decreasing inflammation in both models. These findings suggest that aliskiren is a good candidate for the treatment of inflammatory diseases.

Gastroprotective Effect of Azilsartan Through Ameliorating Oxidative Stress, Inflammation, and Restoring Hydroxyproline, and Gastrin Levels in Ethanol-Induced Gastric Ulcer

“… 46 Additionally, it was able to attenuate the inflammatory markers like CRP and TNF-α and this finding is in tune with other studies. 24 , 47 , 48 These outcomes could be explained depending on the fact that blocking the effects of angiotensin II is directly related to decreasing the oxidative damage and inflammatory process. 49–51 The histopathological findings of the current study were compatible with the biochemical results, where azilsartan showed pronounced protection against ethanol-induced gastric ulcer and in a dose-dependent manner and this was clearly demonstrated as an attenuation in the infiltration of inflammatory cells and reduction in the percentage of necrotic cellular debris.…”

Insight into the hepatoprotective, hypolipidemic, and antidiabetic impacts of aliskiren in streptozotocin-induced diabetic liver disease in mice

“…The volume of injection was 0.25 ml/20 g mice. Different dose levels of aliskiren have been tested before in experimental studies [ 18 , 19 ] . We have selected the least effective dose correlated to the clinical dose used in patients [ 20 ].…”

Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations

“…The right hind-paw was used as a negative control. The plethysmograph method was used on both hind paws of each group of rats to measure the anti-inflammatory activity and compare it to the control and treatment groups [ 43 , 44 ]. This was performed to maintain a constant paw volume.…”