2020
DOI: 10.2147/ott.s223321
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<p>SNHG15 Contributes To Cisplatin Resistance In Breast Cancer Through Sponging miR-381</p>

Abstract: Background: Increasing evidence implies the participation of long non-coding RNAs (lncRNAs) in chemoresistance to cancer treatment. Their role and molecular mechanisms in breast cancer chemoresistance, nevertheless, are yet not considerably elucidated. In this work, we research the function of small nucleolar RNA host gene 15 (SNHG15) in cisplatin (DDP) resistance of breast cancer and uncover the underlying molecular mechanism. Methods: SNHG15 and miR-381 expression levels were detected using Quantitative real… Show more

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Cited by 29 publications
(27 citation statements)
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References 35 publications
(33 reference statements)
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“…Similar trends have also been previously in miR-124-3p [22] and miR-203a [23]. As for miR-381, it has been particularly suggested to play critical functions in overcoming cisplatin resistance in breast cancer treatment [24][25][26].…”
Section: Discussionsupporting
confidence: 79%
“…Similar trends have also been previously in miR-124-3p [22] and miR-203a [23]. As for miR-381, it has been particularly suggested to play critical functions in overcoming cisplatin resistance in breast cancer treatment [24][25][26].…”
Section: Discussionsupporting
confidence: 79%
“…73 LncRNA SNHG15 is upregulated in MCF-7/DDP and MDA-MB-231/DDP cells, and knockdown of SNHG15 increases DDP sensitivity in BC cells by sponging miR-381. 74 LncRNA HCP5 is upregulated in MDA-MB-231/DDP cells and promotes DDP resistance by inhibiting the expression of PTEN; this effect has been observed in TNBC xenografts in vivo. 75…”
Section: Cisplatinmentioning
confidence: 99%
“…52-54 SNHG15 increases the sensitivity of BC cells to DDP by sponging miR-381. 74 CASC2 is upregulated in BC cells and sponges miR-18a-5p to enhance PTX resistance. 68 TINCR sponges miR-125b and promotes TZB resistance in HER-2+ BC cells.…”
Section: Cernasmentioning
confidence: 99%
“…Additionally, SNHG15 knockdown enhances the cisplatin sensitivity of breast cancer cells by acting as a sponge for miR-381. 71 Moreover, bioinformatics analysis showed SNHG16 might be associated with the prognosis of breast cancer. 72,73 In particular, SNHG16 may interact with miR-30a to regulate the expression of ribonucleosidediphosphate reductase subunit M2 (RRM2) 74 and competitively bind miR-98 and the E2F Transcription Factor 5 (E2F5) 75 to promote the proliferation and invasion of breast cancer cells.…”
Section: Breast Cancermentioning
confidence: 99%