&lt;p&gt;Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers&lt;/p&gt;

Qin, Yuan; Sun, Wei; Wang, Zhihong; Dong, Wenwu; He, Liang; Zhang, Ting; Zhang, Hao

doi:10.2147/ott.s267140

Cited by 44 publications

(37 citation statements)

References 149 publications

(176 reference statements)

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“…SNHG1 is associated with endocrine cancers, including BC [ 241 ]. SNHG1 is upregulated in breast tumors and cell lines and promotes cell migration, invasion, and proliferation in vitro, as well as MDA-MB-231 ‘metastasis’ and colonization in the lungs of immune-compromised female mice after tail-vein injection [ 242 ].…”

Section: Resultsmentioning

confidence: 99%

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

Muluhngwi

Klinge

2021

Cancers

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Despite improvements in the treatment of endocrine-resistant metastatic disease using combination therapies in patients with estrogen receptor α (ERα) primary tumors, the mechanisms underlying endocrine resistance remain to be elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNA) and long non-coding RNAs (lncRNA), are targets and regulators of cell signaling pathways and their exosomal transport may contribute to metastasis. Previous studies have shown that a low expression of miR-29a-3p and miR-29b-3p is associated with lower overall breast cancer survival before 150 mos. Transient, modest overexpression of miR-29b1-3p or miR-29a-3p inhibited MCF-7 tamoxifen-sensitive and LCC9 tamoxifen-resistant cell proliferation. Here, we identify miR-29b-1/a-regulated and non-regulated differentially expressed lncRNAs in MCF-7 and LCC9 cells using next-generation RNA seq. More lncRNAs were miR-29b-1/a-regulated in LCC9 cells than in MCF-7 cells, including DANCR, GAS5, DSCAM-AS1, SNHG5, and CRND. We examined the roles of miR-29-regulated and differentially expressed lncRNAs in endocrine-resistant breast cancer, including putative and proven targets and expression patterns in survival analysis using the KM Plotter and TCGA databases. This study provides new insights into lncRNAs in endocrine-resistant breast cancer.

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Section: Resultsmentioning

confidence: 99%

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

Muluhngwi

Klinge

2021

Cancers

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“…SNHGs are the host genes of snoRNAs present in the nucleus and cytoplasm [ 9 ]. To date, it has been reported that the SNHG family has 22 members, from SNHG1 to SNHG22 [ 10 ]. They play significant roles in human cancers and other diseases.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA SNHG4: a novel target in human diseases

Chu

Zheng

et al. 2021

Cancer Cell Int

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Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple studies have been published on the relationship between lncRNA expression and the progression of human diseases. LncRNA small nucleolar RNA host gene 4 (SNHG4), a member of the lncRNA SNHG family, is abnormally expressed in a variety of human diseases, including gastric cancer, renal cell carcinoma, glioblastoma, neuroblastoma, prostate cancer, colorectal cancer, osteosarcoma, cervical cancer, liver cancer, lung cancer, non-small-cell lung cancer, neonatal pneumonia, diabetic retinopathy, neuropathic pain, acute cerebral infarction, acute myeloid leukaemia, and endometriosis. In this paper, the structure of SNHG4 is first introduced, and then studies in humans, animal models and cells are summarized to highlight the expression and function of SNHG4 in the above diseases. In addition, the specific mechanism of SNHG4 as a competing endogenous RNA (ceRNA) is discussed. The findings indicate that SNHG4 can be used as a biomarker for disease prognosis evaluation and as a potential target for disease diagnosis and treatment.

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“…SNHGs are able to induce proliferation, invasion, and metastasis. [19][20][21] Therefore, they are to date an interesting topic of investigation in order to propose as new anticancer therapies. Commonly, snoRNAs are derived by only introns transcript while if the transcript includes also exons, they will be defined as SNHGs.…”

Section: Introductionmentioning

confidence: 99%

“…Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs), the host genes for snoRNAs, are overexpressed in human cancers. SNHGs are able to induce proliferation, invasion, and metastasis 19–21 . Therefore, they are to date an interesting topic of investigation in order to propose as new anticancer therapies.…”

Section: Introductionmentioning

confidence: 99%

Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis

Biagioni¹,

Tavakol

Ahmadirad

et al. 2021

IUBMB Life

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The small nucleolar RNA host genes (SNHGs) belong to the long non-coding RNAs and are reported to be able to influence all three levels of cellular information-bearing molecules, that is, DNA, RNA, and proteins, resulting in the generation of complex phenomena. As the host genes of the small nucleolar RNAs (snoRNAs), they are commonly localized in the nucleolus, where they exert multiple regulatory functions orchestrating cellular homeostasis and differentiation as well as metastasis and chemoresistance. Indeed, worldwide literature has reported their involvement in the epithelial-mesenchymal transition (EMT) of different histotypes of cancer, being able to exploit peculiar features, for example, the possibility to act both in the nucleus and the cytoplasm. Moreover, SNHGs regulation is a fundamental topic to better understand their role in tumor progression albeit such mechanism is still debated. Here, we reviewed the biological functions of SNHGs in particular in the EMT process and discussed the perspectives for new cancer therapies.

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<p>Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers</p>

Cited by 44 publications

References 149 publications

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

Long noncoding RNA SNHG4: a novel target in human diseases

Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis

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