2021
DOI: 10.3390/cancers13143530
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Abstract: Despite improvements in the treatment of endocrine-resistant metastatic disease using combination therapies in patients with estrogen receptor α (ERα) primary tumors, the mechanisms underlying endocrine resistance remain to be elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNA) and long non-coding RNAs (lncRNA), are targets and regulators of cell signaling pathways and their exosomal transport may contribute to metastasis. Previous studies have shown that a low expression of miR-29a-3p and miR-29… Show more

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Cited by 15 publications
(9 citation statements)
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References 273 publications
(381 reference statements)
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“…Inhibition of miR-24-3p in circulating exosomes from diabetic foot ulcer patients restores angiogenesis in vitro and in vivo [56]. Estrogen receptor-regulated miRNAs have already been studied in literature to identify prognostic/predictive markers for cancer, amongst which miR-16-5p and miR-29a-3p have been identified [57][58][59]. Therefore, local estradiol as key regulator in lipedema may regulate local tissue cells such as vascular EC via miRNA signaling.…”
Section: Discussionmentioning
confidence: 99%
“…Inhibition of miR-24-3p in circulating exosomes from diabetic foot ulcer patients restores angiogenesis in vitro and in vivo [56]. Estrogen receptor-regulated miRNAs have already been studied in literature to identify prognostic/predictive markers for cancer, amongst which miR-16-5p and miR-29a-3p have been identified [57][58][59]. Therefore, local estradiol as key regulator in lipedema may regulate local tissue cells such as vascular EC via miRNA signaling.…”
Section: Discussionmentioning
confidence: 99%
“…miRNAs play important roles in tumor progression through tumor suppressor inactivation or regulation of pertinent pathways ( 31 ). miR-29a-3p has been recognized as a critical miRNA in various types of cancer, and typically functions as a tumor suppressor by directly targeting oncogenic genes ( 29 , 32 34 ). miR-29a-3p expression was shown to be downregulated in some cancer types, such as cervical ( 35 ), endometrial ( 13 ), and gastric ( 36 ) cancer, and this downregulation was associated with worse outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…Epigenetic changes, including altered methylation levels at CpG sites that are usually located on the promoters of coding genes, and dysregulation of microRNAs (miRNAs), have been also implicated in several tamR cases [ 18 , 19 ]. Aberrant CpG island methylation has been observed at the promoter of various genes in tamR cancer cells, resulting in dysregulated transcription [ 20 , 21 ].…”
Section: Introductionmentioning
confidence: 99%