<p>Seizure Outcomes in Patients with Complete versus Anterior Corpus Callosotomy: Analysis of Outcome</p>

Abstract

Introduction: Corpus callosotomy (CCT) is a palliative procedure to treat injurious drop attacks or multifocal/generalized seizures in which resection of the epileptogenic focus is not feasible. We are presenting our experience in treating intractable epilepsy patients by CCT procedures. Methods: We observed 16 patients who underwent callosotomy (male to female ratio 7:9; adult to pediatric ratio 3:13). Initial seizure frequency was reported ranged from 1 to 2 attacks daily to very often (more than 20 episodes daily). Results: Our observation showed that among patients with drop attacks, complete and >90% seizure freedom was reported by 4 and 6 of 13 patients, respectively (76.9% combined). Conclusion: Our observation showed that corpus callosotomy yielded good outcome in patients with intractable epilepsy in Indonesia. Our observation showed total callosotomy achieved complete seizure freedom better compared to partial callosotomy patients.

One‐year cost‐effectiveness of callosotomy vs vagus nerve stimulation for drug‐resistant seizures in Lennox‐Gastaut Syndrome: A decision analytic model

“…This analysis was performed given literature suggesting that atonic seizures are the primary indication for CC. 18,19 When the model was performed specifically for atonic seizures, CC had a 27% greater likelihood of a good outcome than VNS and the same incremental cost per patient (ie, $68 147). Compared to when the model considered all seizure types, CC had a more favorable incremental cost compared to VNS of $250 556 per positive seizure outcome gained.…”

Long‐term follow‐up seizure outcomes after corpus callosotomy: A systematic review with meta‐analysis

“…The flow diagram is shown in Figure 1. Finally, 52 retrospective or prospective case series studies (Andersen et al., 1996; Asadi‐Pooya et al., 2013; Baba et al., 2018; Carmant et al., 1998; Cendes et al., 1993; Cohen & Author et al., 1991; Cukiert et al., 2006, 2009, 2013; Duc Lien et al., 2020; Fandiño‐Franky et al., 2000; Ferrand‐Sorbets et al., 2022; Frigeri et al., 2021; Gates et al., 1987; Honda et al., 2021; Iwasaki et al., 2016; Kagawa et al., 2021; Kanai et al., 2020; Kawai et al., 2004; Kim et al., 2004; Kwan et al., 2001, 2006; Liang et al., 2010, 2014, 2015; Lin & Kwan, 2012; Maehara & Shimizu, 2001; Makari et al., 1989; Mamelak et al., 1993; Na et al., 2022; Nordgren et al., 1991; Oguni et al., 1991; Otsuki et al., 2015; Paglioli et al., 2016; Passamonti et al., 2014; Ping et al., 2009; Rathore et al., 2007; Rossi et al., 1996; Sadashiva et al., 2023; Sakas & Phillips, 1996; Shim et al., 2008; Shimizu, 2005; Spencer et al., 1991; Stigsdotter‐Broman et al., 2014; Sunaga et al., 2009; Tanriverdi et al., 2009; Thohar Arifin et al., 2020; Turanli et al., 2006; Ueda et al., 2019; Ukishiro et al., 2022; Yang et al., 2014; You et al., 2008) encompassing 1827 patients were included. The demographic characteristics are shown in Supporting Information S2.…”

“…This meta‐analysis included 52 studies from different countries from 1987 to 2022, with a rate of complete SF ranging from 0% to 66.67%. One meta‐analysis reported SF to be less than 18.8% (Chan et al., 2018 ), and there are many studies on prognosis after CC (Andersen et al., 1996 ; Cukiert et al., 2006 , 2013 ; Honda et al., 2021 ; Kwan et al., 2006 ; Liang et al., 2010 ; Ping et al., 2009 ; Thohar Arifin et al., 2020 ; Ueda et al., 2019 ; Yang et al., 2014 ). However, outcomes of complete SF surgery vary greatly.…”

Dr. Strangelove demystified: Disconnection of hand and language dominance explains alien-hand syndrome after corpus callosotomy

“…Microsurgical anterior 2/3 callosotomy and/or complete callosotomy are established disconnective epilepsy surgical techniques for the treatment of otherwise intractable epilepsies with rapid bihemispheric seizure spread leading to epileptic drop attacks (EDA). Since disconnection symptoms may increase with the amount of corpus callosum transected some surgeons recommend starting anterior, others posterior [11,12]. Notably, disconnection at the level of the SMA may cause AHS [13].…”