&lt;p&gt;ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy&lt;/p&gt;

Ayyanaar, Srinivasan; Balachandran, C.; Bhaskar, R.; Kesavan, Mookkandi Palsamy; Aoki, Shin; Raja, Ramachandran Palpandi; Rajesh, Jegathalaprathaban; Webster, Thomas J; Rajagopal, Gurusamy

doi:10.2147/ijn.s249240

Cited by 46 publications

(15 citation statements)

References 52 publications

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“…This findings also agreed with previous studies that the Fe 3 O 4 composite can be used as an effective inhibitor of antibiotic resistance in medicine, including nanoparticles carrying chemotherapeutic agents used in cancer treatment; our result suggested that the good efficacy might be due to improving the ROS level. 43–45 Thus, we believed that the combination of a conventional cancer drug Ara-C and the IONPs to target upregulation of ROS would be a better approach than using chemotherapeutic agents alone to improve drug-sensitivity for treating AML patients.…”

Section: Resultsmentioning

confidence: 99%

Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species

Dou¹,

Li²,

Guo³

et al. 2021

IJN

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Background and Aim Acute myeloid leukemia (AML), initiated and maintained by leukemia stem cells (LSCs), is often relapsed or refractory to therapy. The present study aimed at assessing the effects of nanozyme-like Fe 3 O 4 nanoparticles (IONPs) combined with cytosine arabinoside (Ara-C) on LSCs in vitro and in vivo. Methods The CD34 + CD38 – LSCs, isolated from human AML cell line KG1a by a magnetic activated cell sorting method, were treated with Ara-C, IONPs, and Ara-C+ IONPs respectively in vitro. The cellular proliferation, apoptosis, reactive oxygen species (ROS), and the related molecular expression levels in LSCs were analyzed using flow cytometry, RT-qPCR, and Western blot. The nonobese diabetic/severe combined immune deficiency mice were transplanted with LSCs or non-LSCs via tail vein, and then the mice were treated with Ara-C, IONPs and IONPs plus Ara-C, respectively. The therapeutic effects on the AML bearing mice were further evaluated. Results LSCs indicated stronger cellular proliferation, more clone formation, and more robust resistance to Ara-C than non-LSCs. Compared with LSCs treated with Ara-C alone, LSCs treated with IONPs plus Ara-C showed a significant increase in apoptosis and ROS levels that might be regulated by nanozyme-like IONPs via improving the expression of pro-oxidation molecule gp91-phox but decreasing the expression of antioxidation molecule superoxide dismutase 1. The in vivo results suggested that, compared with the AML bearing mice treated with Ara-C alone, the mice treated with IONPs plus Ara-C markedly reduced the abnormal leukocyte numbers in peripheral blood and bone marrow and significantly extended the survival of AML bearing mice. Conclusion IONPs combined with Ara-C showed the effectiveness on reducing AML burden in the mice engrafted with LSCs and extending mouse survival by increasing LSC’s ROS level to induce LSC apoptosis. Our findings suggest that targeting LSCs could control the AML relapse by using IONPs plus Ara-C.

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Section: Resultsmentioning

confidence: 99%

Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species

Dou¹,

Li²,

Guo³

et al. 2021

IJN

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“…211 Anticancer drugs are efficient for neutralizing cancer cells 212 but are harmful, which reduces their therapeutic use. 213 Many techniques for cancer treatment such as radiotherapy, surgery and chemotherapy have harmful side effects. 214 Therefore, magnetic nanoparticles are applied due to their ability to perform at the molecular and cellular levels of biological interactions and possess superparamagnetic properties.…”

Section: Application Of Magnetic Chitosan In Cancer Diagnosismentioning

confidence: 99%

Preparation and application of magnetic chitosan in environmental remediation and other fields: A review

Shaumbwa

Liu

Archer

et al. 2021

J of Applied Polymer Sci

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Magnetic chitosan has received considerable attention over the decades due to its low cost, biodegradability, green sources, magnetic intensity. In this review, we reviewed the preparation methods of magnetic chitosan using co-precipitation, cross-linking and electrochemical. Therein cross-linking methodologies involved in the reaction of amino groups are facile to introduce additional reaction groups and improve anti-swelling of chitosan layers, mostly in an acidic environment. Besides, we focused on the applications of magnetic chitosan in various fields such as wastewater treatment, for example, removal of heavy metal ions, organic/inorganic dyes, fluorides, and pesticides. Moreover, magnetic chitosan also reveals great potential application in the field of medical, pharmaceutical, food and electronic screening. Above all, magnetic chitosan is economically and operationally beneficial as it can be easily separated and controlled with an external magnetic field and can be modified to maximize its functions.

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“…Functionalized Fe 3 O 4 nanoparticles released 90% of 5-fluorouracil in response to H 2 O 2 , causing irreversible damage to A549 and HeLa S3 cells. 70 Chitosan-coated MCs were cross-linked with O 6 -benzylguanine to treat temozolomide-resistant glioblastoma models in vitro (GBM6) and in vivo (GBM6 tumors in nude mice). A redox-responsive shell was modified with chlorotoxin to improve MCs targeting to the tumor cells, in which the nanoparticle shell could be reduced by altered redox metabolism.…”

Section: Remote Control Of Redox Effectsmentioning

confidence: 99%

Remote control of magnetic nanocomplexes for delivery and destruction of cancer cells

2021

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Although nanotechnology advances have been exploited for a myriad of purposes, including cancer diagnostics and treatment, still there is little discussion about the mechanisms of remote control. Our main aim here is to explain the possibility of a magnetic field control over magnetic nanocomplexes to improve their delivery, controlled release and antitumor activity. In doing so we considered the nonlinear dynamics of magnetomechanical and magnetochemical effects based on free radical mechanisms in cancer development for future pre-clinical studies.

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<p>ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy</p>

Cited by 46 publications

References 52 publications

Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species

Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species

Preparation and application of magnetic chitosan in environmental remediation and other fields: A review

Remote control of magnetic nanocomplexes for delivery and destruction of cancer cells

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