&lt;p&gt;Retinal Vasculitis with Macular Infarction: A Dengue-related Ophthalmic Complication&lt;/p&gt;

Agarwal, Lokesh; Agrawal, Nisha

doi:10.2147/imcrj.s264324

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…A recent (2021) case series with 23 patients reported panophthalmitis, endophthalmitis, orbital cellulitis with panophthalmitis, and orbital haemorrhage with panophthalmitis in 10, 11, 4, and 1 patient(s), respectively 58,90 . Vascular occlusions and vitreous haemorrhages are uncommon posterior segment findings in dengue patients 42,91 . They represent an enhanced immune response, as the DENV NS1 antigen can cause endothelial cell monolayer rupture mediated by the inflammatory cytokines produced via TLR 4 activation of macrophages and human PBMCs 19,92 .…”

Section: Clinical Features Of Dengue Eye Diseasementioning

confidence: 99%

“…58,90 Vascular occlusions and vitreous haemorrhages are uncommon posterior segment findings in dengue patients. 42,91 They represent an enhanced immune response, as the DENV NS1 antigen can cause endothelial cell monolayer rupture mediated by the inflammatory cytokines produced via TLR 4 activation of macrophages and human PBMCs. 19,92 Additionally, immune cell NS1-mediated release of inflammatory cytokines induces endothelial hyperpermeability and vascular leakage, affecting the anterior and posterior segments as well as vascular structures of the eye.…”

Section: Other Ocular Manifestationsmentioning

confidence: 99%

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Dengue fever ophthalmic manifestations: A review and update

Lucena‐Neto

Falcão

Moraes

et al. 2023

Reviews in Medical Virology

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Dengue fever, the most common arbovirus disease, affects an estimated 390 million people annually. Dengue virus (DENV) is an RNA virus of the Flaviviridae family with four different serotypes. Dengue haemorrhagic fever is the deadliest form of dengue infection and is characterised by thrombocytopaenia, hypotension, and the possibility of multi-system organ failure. The mechanism hypothesised for DENV viral replication is intrinsic antibody-dependent enhancement, which refers to Fcγ receptor-mediated viral amplification. This hypothesis suggests that the internalisation of DENV through the Fcγ receptor inhibits antiviral genes by suppressing type-1 interferon-mediated antiviral responses. DENV NS1 antibodies can promote the release of various inflammatory mediators in the nuclear transcription factor pathway (NF-κB-dependent), including monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6, and IL-8. As a result, MCP-1 increases ICAM-1 expression and facilitates leukocyte transmigration. In addition, anti-DENV NS1 antibodies induce endothelial cell apoptosis via a nitric oxide-regulated pathway. A chain reaction involving pre-existing DENV heterotypic antibodies and innate immune cells causes dysfunction in complement system activity and contributes to the action of autoantibodies and anti-endothelial cells, resulting in endothelial cell dysfunction, bloodretinal barrier breakdown, haemorrhage, and plasma leakage. A spectrum of ocular diseases associated with DENV infection, ranging from haemorrhagic to

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Section: Clinical Features Of Dengue Eye Diseasementioning

confidence: 99%

Section: Other Ocular Manifestationsmentioning

confidence: 99%

Dengue fever ophthalmic manifestations: A review and update

Lucena‐Neto

Falcão

Moraes

et al. 2023

Reviews in Medical Virology

View full text Add to dashboard Cite

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“…Cases of stromal keratitis, necrotizing scleritis (32), anterior uveitis and panophthalmitis are infrequent but have been described. Numerous posterior segment findings have been noted, including vitritis, retinal hemorrhage, retinal vasculitis (33), choroiditis (34), foveolitis, yellow subretinal lesions, optic neuritis and neuroretinitis (35). Fluorescein angiography can reveal vascular leakage and occlusion while indocyanine green angiography can show hypocyanescent spots corresponding to the yellow subretinal lesions and large areas of choroidal hypercyanescence.…”

Section: Dengue Fevermentioning

confidence: 99%

Ophthalmic consequences of viral hemorrhagic fevers: Insights from the clinic and laboratory

Karnam

Huang²,

Yeh³

2023

Front. Trop. Dis

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Viral hemorrhagic fevers (VHFs) are a diverse group of RNA virus-mediated systemic diseases with significant morbidity and mortality and represent a significant public health concern. Given the high systemic morbidity and mortality in a number of these entities, delays in diagnosis can lead to downstream public health consequences. Many viral hemorrhagic fevers have ophthalmic manifestations and ophthalmologists thus play a key role in disease recognition and the management of ocular complications associated with specific hemorrhagic fevers. This review summarizes the key ophthalmic consequences of viral hemorrhagic fevers, viral disease pathogenesis, disease findings, and areas of unmet research need.

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“…Vision loss in dengue retinopathy could be due to macular edema, pre-retinal/intraretinal hemorrhages, denguerelated foveolitis, and microvascular changes. Rare manifestations of dengue retinopathy include acute macular neuroretinopathy (AMN) [40][41][42][43][44].…”

Section: Dengue West Nile Fever and Other Rna Virusesmentioning

confidence: 99%

A Comprehensive Update on Retinal Vasculitis: Etiologies, Manifestations and Treatments

Agarwal

Rübsam

Bonsen

et al. 2022

JCM

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Retinal vasculitis is characterized by inflammatory involvement of retinal arterioles, venules and/or capillaries and can be associated with a myriad of systemic and ophthalmic diseases. In this review, we have comprehensively discussed the etiologies, clinical manifestations, and presentations of retinal vasculitis. We have also included newer advances in imaging in retinal vasculitis such as OCTA and widefield imaging.

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<p>Retinal Vasculitis with Macular Infarction: A Dengue-related Ophthalmic Complication</p>

Cited by 7 publications

References 14 publications

Dengue fever ophthalmic manifestations: A review and update

Dengue fever ophthalmic manifestations: A review and update

Ophthalmic consequences of viral hemorrhagic fevers: Insights from the clinic and laboratory

A Comprehensive Update on Retinal Vasculitis: Etiologies, Manifestations and Treatments

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