<p>Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol</p>

Abstract

IntroductionMalnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.MethodsWe included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).ResultsSignificant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 ± 518.73 vs 1795.65 ± 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 ± 69.21 vs 50.19 ± 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 ± 0.75 vs 2.50 ± 0.85; p = 0.50).DiscussionThe present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.

Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials

“…Two additional relevant papers were recognized by searching the reference list of eligible publications. After screening the retrieved manuscripts based on titles and abstracts, we retrieved 20 full texts [ 23 – 25 , 35 ] [ 30 , 36 – 38 ] [ 39 – 41 ] [ 42 , 43 ] [ 44 , 45 ] [ 46 – 48 ] [ 49 ]. 10 were excluded [ 41 – 50 ] and 10 were finally included in the review and meta-analysis according to inclusion and exclusion criteria [ 23 – 25 , 30 , 35 – 40 ].…”

“…10 were excluded [ 41 – 50 ] and 10 were finally included in the review and meta-analysis according to inclusion and exclusion criteria [ 23 – 25 , 30 , 35 – 40 ]. Trials were excluded for the following reasons: not randomized controlled trials [ 47 ] ( n = 1), unsuitable control group [ 45 , 46 ] ( n = 2), outcome of interest not reported [ 41 – 44 , 50 ] ( n = 5), and outcomes from the same dataset [ 48 , 49 ] (n = 2).…”

The Discovery of Druggable Anti-aging Agents

“…Curcumin in combination with resveratrol alleviated this damage and helped to significantly increase the muscle and bone mass of patients after 12 weeks of supplementation. 69 ) In healthy middle-aged and older people, curcumin improved resistance artery endothelial function by reducing oxidative stress, although it did not affect arterial stiffness. 70 )…”

“…Curcumin in combination with resveratrol alleviated this damage and helped to significantly increase the muscle and bone mass of patients after 12 weeks of supplementation. 69) In healthy middle-aged and older people, curcumin improved resistance artery endothelial function by reducing oxidative stress, although it did not affect arterial stiffness. 70) Other phenols Antioxidants are widely accepted as anti-aging compounds, and resveratrol, also a natural phenol; quercetin; CAPE; and curcumin have all been shown to modulate, increase, or ameliorate the activity of major antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx).…”

Bioactive Compounds for the Management of Hypertriglyceridemia: Evidence From Clinical Trials and Putative Action Targets

“…However, a modest number of studies described marked and significant TG-reducing effects, providing evidence for individuation of such effective phytochemicals for designing nutraceutical formulations. In this section we summarize the most relevant clinical trials reporting the TG-reducing effect of food-derived bioactive compounds (listed and detailed in Table 1), including omega-3 (6-33), niacin (34,35), Trigonella foenum-graecum L. (36,37), fiber (38)(39)(40)(41)(42)(43)(44)(45), vitamin E (46,47), and polyphenols (48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61).…”