Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials

Abstract

Background The results from clinical trials have revealed that the effects of resveratrol supplementation on bone mineral density (BMD) and bone biomarkers are inconsistent. Our objective was to determine the effects of resveratrol supplementation on BMD and serum bone biomarkers. Methods PubMed, Cochrane library, EMBASE, Web of science and Scopus were searched up to August 24, 2020. Two reviewers independently performed the articles search and screen according to defined selection criteria. The study quality of the randomized controlled trials (RCTs) was evaluated with the Cochrane scoring system. Heterogeneity among studies was examined by Cochrane Q test. Retrieved data were pooled after mean differences (MD) were computed between two groups for BMD and serum biomarkers. Subgroup analyses were performed to evaluate a potential difference in terms of dose of resveratrol and intervention duration. Sensitivity analysis was executed by omitting studies with imputed values in order to evaluate the influence of these studies on the overall results. Results Ten eligible studies involving 698 subjects were included in this meta-analysis with 401 participants receiving resveratrol and 297 receiving placebo. Supplementation of resveratrol had no statistically significant effects on areal bone mineral density (aBMD) at lumbar spine (MD: -0.02, 95% CI: − 0.05, 0.01, p = 0.26, I2 = 6%), total hip BMD (MD: -0.01, 95% CI: − 0.04, 0.02, p = 0.65, I2 = 0%), and whole body BMD (MD: 0.00, 95% CI: − 0.02, 0.02, p = 0.74, I2 = 0%). Supplementation of resveratrol also did not result in significant change in bone serum markers, including serum alkaline phosphatase (ALP), bone alkaline phosphatase (BAP), osteocalcin (OCN), procollagen I N-terminal propeptide (PINP), C-terminal telopeptide of type I collagen (CTX) and parathyroid hormone (PTH). Subgroup analysis showed the effect of resveratrol supplementation on BMD and serum bone markers were similar in trails of different doses, intervention duration, and pathological conditions of the participants. Conclusion Resveratrol supplementation did not show any significant effect on BMD or serum bone markers with the current evidence. Further investigation with more well-organized multicentre randomized trial is warranted.

Protective effect and possible mechanisms of resveratrol in animal models of osteoporosis: A preclinical systematic review and meta‐analysis

“…Those outcomes provide the theoretical basis for future study on RES‐based therapies for OP sufferers. Our findings are inconsistent with the previous systematic review and meta‐analysis that suggested RES supplementation did not significantly increase BMD at lumbar spine and hip in clinical OP patients (Li, Sun, et al, 2021; Li, Yang, et al, 2021). Such discrepancies between animal and human clinical studies are not unexpectable, which provides us several implications for future research.…”

“…Blinding in animal models and result evaluation is often challenging for most studies. Sample size computation could prevent oversized sampling and inaccuracy caused by undersized sampling (Gupta et al, 2016) (Li, Sun, et al, 2021;Li, Yang, et al, 2021). Such discrepancies between animal and human clinical studies are not unexpectable, which provides us several implications for future research.…”

“…At present, the main drugs for OP are divided into two types based on their mechanism of action: antiresorptive therapy (bisphosphonates, denosumab, selective estrogen receptor modulators) and anabolic therapy (teriparatide, romosozumab) (Chin et al, 2022). Bisphosphonates, the most commonly used osteoclast activity inhibitors, have been reported to decrease the risk of spinal or hip fractures in OP sufferers (Li, Sun, et al, 2021; Li, Yang, et al, 2021). Currently, estrogen replacement therapy (ERT) is a clinically recognized effective program for treating postmenopausal osteoporosis (PMOP), which reduces the risk of fracture by 50%.…”

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

“…Anthocyanins could suppress lipid accumulation in adipocytes [ 212 ] and reduce high-fat diet-induced metabolic damage [ 213 ]. Body mass index and body weight were reduced when anthocyanin supplementation was 300 mg/d or less for 4 weeks [ 214 ]. Cyanidin 3-caffeoyl-p-hydroxybenzoylsophoroside-5-glucoside as an anthocyanin isolated from purple-fleshed sweet potato showed hypoglycemic effects by specifically suppressing hepatic glucose output [ 215 ].…”

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

“…A 24-month RES (RESHAW) trial of healthy ageing in women showed that regular 75 mg resveratrol supplementation twice daily had the potential to slow bone loss in the lumbar spine and femoral neck, which is common at fracture sites in postmenopausal women without significant osteoporosis ( Wong et al, 2020 ). However, a systematic review and meta-analysis showed that RES supplements did not show any significant effect on BMD or serum bone markers ( Li Q. et al, 2021 ). Therefore, further research utilizing better organized multicenter randomized trials is necessary so that physicians can provide more advice for clinical decision-making.…”