&lt;p&gt;Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway&lt;/p&gt;

Liu, Dequan; Wang, Huilin; Zhang, Yangang; Zhang, Zhan

doi:10.2147/dddt.s228751

Cited by 143 publications

(104 citation statements)

References 42 publications

(41 reference statements)

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“…Also, another study in a rat model of cerebral ischemia (CI) demonstrated that 5‐CQA reduces brain injury, brain edema, sensory‐motor functional deficits, and BBB damage by enhancing free‐radical scavenging activity and inhibiting interstitial collagenase (MMP1) and 72 kDa type IV collagenase (MMP2) (Lee et al., 2012). Furthermore, a recent study showed that 5‐CQA reduces brain damage, nerve damage, and volume of cerebral infarction and neuronal apoptosis by regulating the NFE2L2 signaling pathway in CI‐reperfusion (CI/R)‐induced oxidative stress in rats (Liu, Wang, Zhang, & Zhang, 2020). According to Hermawati, Arfian, Mustofa, and Partadiredja (2020), 5‐CQA improved spatial memory and prevented the degeneration of hippocampal CA1 pyramidal cells in CI/R rats, which may be attributed to increased expression of Bcl2 , platelet endothelial cell adhesion molecule ( Pecam1 , also known as Cd31 ), and superoxide dismutase [Mn], mitochondrial ( Sod2 ), as well as the suppression of the expression of endothelin‐1 ( Edn1 , also known as Et‐1 ).…”

Section: Beneficial Properties For Healthmentioning

confidence: 99%

Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Tian

Cui

et al. 2020

Comp Rev Food Sci Food Safe

235

179

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Chlorogenic acids (CGAs), a group of hydroxycinnamates, are generally abundant in everyday foods and beverages, most prominently in certain coffee drinks. Among them, the chlorogenic acid (CGA), also termed as 5-O-caffeoylquinic acid (5-CQA), is one of the most abundant, highly functional polyphenolic compounds in the human diet. The evidence of its health benefits obtained from clinical studies, as well as basic research, indicates an inverse correlation between 5-CQA consumption and a lower risk of metabolic syndromes and chronic diseases. This review focuses on the beneficial properties for health and mechanisms of action of 5-CQA, starting with its history, isomers, dietary sources, processing effects, preparation methods, pharmacological safety evaluation, and bioavailability. It also provides the possible molecular mechanistic bases to explain the health beneficial effects of 5-CQA including neuroprotective, cardiovascular protective, gastrointestinal protective, renoprotective, hepatoprotective, glucose and lipid metabolism regulatory, and anticarcinogenic effects. The information summarized here could aid in the basic and clinical research on 5-CQA as a natural dietary additive, potential drug candidate, as well as a natural health promoter.

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Section: Beneficial Properties For Healthmentioning

confidence: 99%

Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Tian

Cui

et al. 2020

Comp Rev Food Sci Food Safe

235

179

View full text Add to dashboard Cite

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“…Chlorogenic acid was also reported to ameliorate brain ischemia-induced injury in rodents. In models of cerebral ischemia/reperfusion injury, it significantly reduced mortality [ 314 ], improved neurological deficit scores [ 314 , 315 ], attenuated sensory-motor functional deficits [ 316 ], reduced infarct volume [ 314 , 315 , 316 , 317 ], suppressed CA1 pyramidal cell loss [ 318 , 319 , 320 ], decreased brain edema [ 315 , 316 , 317 ], and attenuated blood–brain barrier (BBB) damage [ 316 , 317 ]. Importantly, it was demonstrated that chlorogenic acid has a neuroprotective effect against ischemia-induced cognitive deficits.…”

Section: Neuroprotective Effects Of Coffee Bioactive Compoundsmentioning

confidence: 99%

Neuroprotective Effects of Coffee Bioactive Compounds: A Review

Socała

Szopa

Serefko

et al. 2020

IJMS

134

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Coffee is one of the most widely consumed beverages worldwide. It is usually identified as a stimulant because of a high content of caffeine. However, caffeine is not the only coffee bioactive component. The coffee beverage is in fact a mixture of a number of bioactive compounds such as polyphenols, especially chlorogenic acids (in green beans) and caffeic acid (in roasted coffee beans), alkaloids (caffeine and trigonelline), and the diterpenes (cafestol and kahweol). Extensive research shows that coffee consumption appears to have beneficial effects on human health. Regular coffee intake may protect from many chronic disorders, including cardiovascular disease, type 2 diabetes, obesity, and some types of cancer. Importantly, coffee consumption seems to be also correlated with a decreased risk of developing some neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and dementia. Regular coffee intake may also reduce the risk of stroke. The mechanism underlying these effects is, however, still poorly understood. This review summarizes the current knowledge on the neuroprotective potential of the main bioactive coffee components, i.e., caffeine, chlorogenic acid, caffeic acid, trigonelline, kahweol, and cafestol. Data from both in vitro and in vivo preclinical experiments, including their potential therapeutic applications, are reviewed and discussed. Epidemiological studies and clinical reports on this matter are also described. Moreover, potential molecular mechanism(s) by which coffee bioactive components may provide neuroprotection are reviewed.

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“…Chlorogenic acid, the major polyphenolic compound in coffee, has a neuroprotective effect against cerebral ischemia/reperfusion (CI/R) rats by activating the Nrf2 pathway and inducing NQO1 and HO-1 expression [ 149 ]. Furthermore, lyciumamide A from wolfberry can prevent CI/RI by activating the PKC/Nrf2/HO-1 signaling pathway, thereby ameliorating oxidative damage and attenuating neuronal apoptosis [ 150 ].…”

Section: Nrf2 Signaling Pathway and Cerebrovascular Disease (Cd)mentioning

confidence: 99%

Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

Cheng

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Cardiocerebral vascular disease (CCVD) is a common disease with high morbidity, disability, and mortality. Oxidative stress (OS) is closely related to the progression of CCVD. Abnormal redox regulation leads to OS and overproduction of reactive oxygen species (ROS), which can cause biomolecular and cellular damage. The Nrf2/antioxidant response element (ARE) signaling pathway is one of the most important defense systems against exogenous and endogenous OS injury, and Nrf2 is regarded as a vital pharmacological target. The complexity of the CCVD pathological process and the current difficulties in conducting clinical trials have hindered the development of therapeutic drugs. Furthermore, little is known about the role of the Nrf2/ARE signaling pathway in CCVD. Clarifying the role of the Nrf2/ARE signaling pathway in CCVD can provide new ideas for drug design. This review details the recent advancements in the regulation of the Nrf2/ARE system and its role and activators in common CCVD development.

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<p>Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway</p>

Cited by 143 publications

References 42 publications

Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Neuroprotective Effects of Coffee Bioactive Compounds: A Review

Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

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