Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

Cheng, Liangkai; Zhang, Hong; Wu, Fang; Liu, Zhongqiu; Cheng, Yuanyuan; Wang, Caiyan

doi:10.1155/2020/4683943

Cited by 14 publications

(14 citation statements)

References 184 publications

(175 reference statements)

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“…As is known, Nrf2 plays an important role in maintaining redox homeostasis in cardiac cells and is also a crucial regulatory component of cellular antioxidant defense against oxidative stress in the myocardium (cardiovascular system). Furthermore, Nrf2 can contribute to protecting heart and blood vessels under stress conditions and its activation leads to the prevention and delay of cardiovascular diseases [ 40 ]. Several studies have documented the involvement of Nrf2 signaling in mechanisms of cardioprotection and in the regulation of cardiac function at different pathological conditions [ 41 , 42 , 43 , 44 ].…”

Section: Nrf-2 Redox Signaling In Cell Responses To Oxidative Stressmentioning

confidence: 99%

The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

Boťanská

Dovinová

Barančı́k

2022

Cells

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Reactive oxygen and nitrogen species produced at low levels under normal cellular metabolism act as important signal molecules. However, at increased production, they cause damage associated with oxidative stress, which can lead to the development of many diseases, such as cardiovascular, metabolic, neurodegenerative, diabetes, and cancer. The defense systems used to maintain normal redox homeostasis plays an important role in cellular responses to oxidative stress. The key players here are Nrf2-regulated redox signaling and autophagy. A tight interface has been described between these two processes under stress conditions and their role in oxidative stress-induced diseases progression. In this review, we focus on the role of Nrf2 as a key player in redox regulation in cell response to oxidative stress. We also summarize the current knowledge about the autophagy regulation and the role of redox signaling in this process. In line with the focus of our review, we describe in more detail information about the interplay between Nrf2 and autophagy pathways in myocardium and the role of these processes in cardiovascular disease development.

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Section: Nrf-2 Redox Signaling In Cell Responses To Oxidative Stressmentioning

confidence: 99%

The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

Boťanská

Dovinová

Barančı́k

2022

Cells

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“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with antioxidant effects strongly related to several CVDs [ 6 ]. Nrf2 regulates the biosynthesis, utilization, and regeneration of glutathione, thioredoxin, and NADPH, as well as the production of reactive oxygen species via the mitochondria and NADPH oxidase, to maintain cellular redox homeostasis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis

Huang

Zeng

et al. 2022

Cardiology Research and Practice

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Cardiovascular disease (CVD) is a serious public health issue in China, accounting for more than 40% of all mortality, and it is the leading cause of death worldwide. Atherosclerosis is the pathological basis for much CVD, including coronary heart disease, acute myocardial infarction, and stroke. Endothelial dysfunction is an initiating and exacerbating factor in atherosclerosis. Recent research has linked oxidative stress and mitochondrial damage to endothelial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with antioxidant effects that is strongly connected to several CVDs. However, the mechanism by which Nrf2 reduces CVD is unknown. Research indicates that Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis. This article examines the mechanisms and potential targets of Nrf2 affecting endothelial cell function to improve atherosclerosis and to provide ideas for the development of new CVD treatments.

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“…For example, excessive ROS accumulation induces chronic inflammation, extracellular matrix (ECM) disorganization, DNA damage and eventually angiogenesis defects [ 6 ]. The downstream effectors of ROS include antioxidant genes such as NRF2 , HMOX1, NOS2 and SOD1 [ 7 , 8 ]. Specifically, NRF2 has been associated with cardiovascular pathogenesis [ 8 , 9 ], exhibiting protective effects via the induction of a series of antioxidant genes [ 10 , 11 ], but opposite effects were also observed in atherosclerotic exacerbation or myocardial dysfunction [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation

et al. 2022

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Cigarette smoke significantly induces oxidative stress, resulting in cardiovascular disease. NRF2, a well-known antioxidative stress response factor, is generally considered to play protective roles in cardiovascular dysfunction triggered by oxidative stress. Interestingly, recent studies reported adverse effects of NRF2 on the cardiovascular system. These unfavourable pathogenic effects of NRF2 need to be further investigated. Our work shows that cigarette smoke extract (CSE)-induced oxidative stress disturbs fibronectin (FN) assembly during angiogenesis. Furthermore, this effect largely depends on hyperactive NRF2-STAT3 signalling, which consequently promotes abnormal FN deposition. Consistently, disruption of this pathway by inhibiting NRF2 or STAT3 prevents CSE-induced FN disorganization and vasculature disruption in human umbilical vein endothelial cells or zebrafish. Taken together, these findings demonstrate the cardiovascular dysfunction caused by CSE from a novel perspective that NRF2-dependent signalling engages in FN disorganization.

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Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

Cited by 14 publications

References 184 publications

The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis

Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation

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