<p>Prognostic Significance Of The Inflammatory Index-Based Scoring System In Patients Preliminarily Diagnosed With Multiple Myeloma In The Bortezomib-Based Chemotherapy Era</p>

Abstract

PurposeRed blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet count (PLT) have been reported to be associated with the prognosis of malignancies; this study aimed to evaluate the prognostic significance of the inflammatory prognostic scoring index (IPSI), comprised of RDW, N LR, and PLT for overall survival (OS) in newly diagnosed multiple myeloma patients in the bortezomib-based chemotherapy era.Patients and methodsThe prognostic significance of variables associated with the OS of 175 newly diagnosed multiple myeloma patients was evaluated through univariate and multivariate analyses. The cut-off values of RDW, NLR, and PLT were obtained from references. Patients with high RDW (RDW>14) were given a score of 1; patients with high NLR (NLR>2) or low PLT (PLT≤150) were given a score of 2. According to the obtained scores, the inflammatory prognostic scoring index (IPSI) was formed, in which patients were grouped into high-risk group (4–5 points), intermediate-risk group (3 points) and low-risk group (0–2 points).ResultsOS varied significantly in different IPSI groups (P< 0.001). On multivariate analysis, the IPSI was an independent prognostic factor for OS (intermediate-risk group HR 2.89, 95% CI 1.60–5.22, high risk-group HR 14.50, 95% CI 7.26–28.93, P<0.001). Importantly, with IPSI as supplement to the International Staging System (ISS), a significant difference in OS was observed among IPSI subgroups (ISS I, P<0.001; ISS II, P=0.008; ISS III, P<0.001).ConclusionThe IPSI, comprised of RDW, NLR, and PLT, played specific role in the prognosis of patients preliminarily diagnosed with multiple myeloma in the bortezomib-based chemotherapy era and could be a beneficial supplement for ISS staging.

Hematopoietic Score for the Prognostic Evaluation of Multiple Myeloma Patients Undergoing First-Line Treatment With A Bortezomib-Based Regimen

“…Regardless, this may not be related to macrocytosis in these patients, and some patients with vitamin B12 de ciency do not show an increase in their MCV (11,18). It is believed that increased an erythrocyte volume is more common in elderly patients, which may be related to the shortened erythrocyte life span and the emergence of more new erythrocytes (reticulocytes) to replace the lost red blood cells, resulting in a slightly larger volume (20) and an increased peripheral blood red blood cell distribution width (9,21).…”

Evaluation of the UK Myeloma Research Alliance Risk Profile in Chinese Patients with Newly Diagnosed Multiple Myeloma without Autologous Stem Cell Transplantation

“… 8 On the contrary, based on tumor factors, Kim et al and Liu et al successively put forward the MPI and IPSI risk assessment models, and confirmed their survival relevance with MM. 9 , 10 The MPI comprised NLR, PLT, and CRP, while the IPSI consisted of RDW, NLR, and PLT. Both models played an important role in the prognosis of NDMM in the bortezomib-based chemotherapy era and identified that inflammatory factors affect the prognosis of MM.…”

“…Both models played an important role in the prognosis of NDMM in the bortezomib-based chemotherapy era and identified that inflammatory factors affect the prognosis of MM. 9 , 10 Of course, ISS and RISS are still more commonly used in the clinical setting. In 2019, the British Myeloma Research Alliance first proposed the prognosis evaluation model of MRP composed of physical fitness score, age, ISS stage, and CRP using the data from the NCRI Myeloma XI study [NCRI-XI, n=1852] and the MRC Myeloma IX study [MRC-IX, n=520].…”

Haematopoietic Score for the Prognostic Evaluation of Multiple Myeloma Patients Undergoing First-line Treatment With a Bortezomib-based Regimen

“…Regardless, this may not be related to macrocytosis in these patients, and some patients with vitamin B12 de ciency do not show an increase in their MCV (9,16). It is believed that increased an erythrocyte volume is more common in elderly patients, which may be related to the shortened erythrocyte life span and the emergence of more new erythrocytes (reticulocytes) to replace the lost red blood cells, resulting in a slightly larger volume (18) and an increased peripheral blood red blood cell distribution width (12,19).…”