&lt;p&gt;Prevalence of Metabolic Syndrome and Association with Grip Strength in Older Adults: Findings from the HOPE Study&lt;/p&gt;

Merchant, Reshma Aziz; Chan, Yiong Huak; Lim, Jia Yi; Morley, John E.

doi:10.2147/dmso.s260544

Cited by 37 publications

(45 citation statements)

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“…Sarcopenia and cognition are closely related, both associated with aging and still an area of ongoing research. Sarcopenia is a risk factor for metabolic syndrome as skeletal muscle plays a crucial role in body's glucose metabolism, and both conditions either in isolation or together are associated with increased prevalence of cognitive impairment (40). Brain-derived neurotrophic factor released by contracting skeletal muscles is responsible for synapse and structural connectivity.…”

Section: Discussionmentioning

confidence: 99%

Possible Sarcopenia and Impact of Dual-Task Exercise on Gait Speed, Handgrip Strength, Falls, and Perceived Health

et al. 2021

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Background: Sarcopenia is defined as a progressive age-related loss in muscle mass and strength affecting physical performance. It is associated with many negative outcomes including falls, disability, cognitive decline, and mortality. Protein enriched diet and resistance training have shown to improve muscle strength and function but there is limited evidence on impact of dual-task exercise in possible sarcopenia.Objective: To evaluate impact of community-based dual-task exercise on muscle strength and physical function in possible sarcopenia defined by either slow gait (SG) or poor handgrip strength (HGS). The secondary aims include effect on cognition, frailty, falls, social isolation, and perceived health.Methods: Community-dwelling older adults ≥60 years old were recruited from screening program intended to identify seniors at risk, and invited to participate in dual-task exercise program called HAPPY (Healthy Aging Promotion Program for You). One hundred and eleven participants with possible sarcopenia completed 3 months follow-up. Questionnaire was administered on demographics, frailty, sarcopenia, falls, perceived health, social network, functional, and cognitive status. Physical performance included assessment of HGS, gait speed, and Short Physical Performance Battery test (SPPB).Results: The mean age of the Exercise group was 75.9 years old and 73.0% were women. The Exercise group had more female (73.0 vs. 47.5%), were older (75.9 vs. 72.5 years old), had higher prevalence of falls (32.4 vs. 15.0%), lower BMI (23.7 vs. 25.8), and education (4.0 vs. 7.2 years). The gait speed of the Exercise group increased significantly with significant reduction in the prevalence of SG and poor HGS. All components of SPPB as well as the total score increased significantly while the prevalence of pre-frailty and falls dropped by half. The risk of social isolation reduced by 25% with significant improvement in perceived health and cognition in the Exercise group. Significant impact on improvement gait speed and SPPB persisted after adjustment for baseline factors.Conclusion: Dual-task exercise program is effective in improving gait speed, SPPB score, and reducing the prevalence of poor HGS with significant improvement in perceived health, cognition, and reduction in falls and frailty. Future prospective randomized control trials are needed to evaluate the effectiveness of dual-task interventions in reversing sarcopenia.

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Section: Discussionmentioning

confidence: 99%

Possible Sarcopenia and Impact of Dual-Task Exercise on Gait Speed, Handgrip Strength, Falls, and Perceived Health

et al. 2021

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“…The association of HGS in metabolic syndrome and obesity is an evolving area of research where recent studies suggest that relative HGS measured by either HGS/BMI or HGS/body weight may better predict negative outcomes in obese older adults ( 15 ). Male in the high BMI without CO group had significantly higher HGS than the normal BMI without CO group but was no longer significant after adjusting for confounding factors.…”

Section: Discussionmentioning

confidence: 99%

“…Only 754 participants with available measurements on waist circumference (WC) and BMI were included in the current analysis. Further details on recruitment, interview questionnaire, physical and cognitive assessment were elaborated in prior published studies ( 14 , 15 ).…”

Section: Methodsmentioning

confidence: 99%

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Association of central obesity and high body mass index with function and cognition in older adults

Merchant

Kit

Lim

et al. 2021

Endocrine Connections

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Objective: To investigate the association of normal body mass index (BMI) with central obesity (CO), high BMI with CO, high BMI without CO, and normal BMI without CO, with function and cognition in older adults. Methods: Cross-sectional study involving 754 participants ≥ 65 years. Data collected include demographics, cognition and physical measurements. Results: Females had higher prevalence of high BMI with CO and lower prevalence of high BMI without CO than males (61.0% vs. 44.6% and 4.6% vs. 15.0% respectively). Within gender, CO groups, regardless of BMI, had lower mini-mental state examination (MMSE), handgrip strength (HGS) and Timed-Up-and-Go (TUG) scores. Overall, the high BMI without CO group had highest MMSE scores, HGS, and shortest TUG. Amongst males, HGS was significantly lower in the normal BMI with CO group (B -3.28, 95% CI -6.32 - -0.23, p=0.04). CO, regardless of normal/high BMI, had significantly longer TUG time (B 2.65, 95% CI 0.45 - 4.84, p = 0.02; B 1.07, 95% CI 0.25 - 1.88, p=0.01 respectively) than normal BMI without CO group. CO was associated with lower MMSE scores in both genders but significant only in males with normal BMI and CO (B -1.60, 95% CI -3.15 - -0.06, p=0.04). Conclusion: CO may be a better predictor of obesity and adverse outcomes in older adults. High BMI without CO was associated with better outcomes especially in males but require further validation. Prospective longitudinal studies are needed to ascertain the impact of BMI and/or CO on function, cognition, mortality and gender differences.

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“…Beberapa penelitian sebelumnya juga telah dieksplorasi bahwa sindrom metabolik pada lansia yang tinggal di komunitas Cina berkorelasi terhadap kekuatan genggaman tangan (Song et al, 2020). Akan tetapi, lansia yang berusia di atas 65 tahun di Singapura menunjukkan bahwa kekuatan genggaman tangan memiliki korelasi negatif yang signifikan dengan sindrom metabolik (Merchant et al, 2020).…”

Section: Kaitan Prevalensi Sindrom Metabolik Terhadap Kekuatan Genggaunclassified

Sosio-Ekonomi, Sindrom Metabolik terhadap Kekuatan Genggaman Tangan Lansia di Komunitas

Sumandar¹,

Fadhli²,

Mayasari³

2021

j. kesehat.

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Latar Belakang: Kekuatan genggaman tangan pada lansia merupakan indikasi kesehatan fisik dan mobilitas. Faktor penyebab penurunan kondisi ini adalah karakteristik lansia serta kondisi penyakit yang diderita. Kondisi ini pun dapat meningkatkan risiko keterbatasan mobilitas serta dapat memprediksi kerugian bagi lansia seperti ketergantungan dalam pelaksanaan aktivitas sehari-hariTujuan: Untuk menganalisis hubungan jenis kelamin, status pekerjaan, dan sindrom metabolik dengan kekuatan genggaman tangan pada lansia.Metode: Penelitian ini bersifat observasional analitik dengan pendekatan cross sectional. Data dikumpulkan berdasarkan jenis kelamin, status pekerjaan, sindrom metabolik, dan kekuatan pegangan tangan. Sampel sebanyak 102 lansia yang berada komunitas kota Pekanbaru dengan teknik cluster sampling.Hasil: Penelitian menunjukkan bahwa kekuatan genggaman tangan rendah sebanyak 60,8%, jenis kelamin perempuan sebanyak 66,7%, tidak bekerja sebanyak 70,6%, dan prevalensi sindrom metabolik sebanyak 20,6%. Terdapat kaitan antara jenis kelamin, status pekerjaan, dan kejadian sindrom metabolik terhadap kekuatan genggaman tangan lansia ( p = 0,000; OR = 6,27; 95% CI = 2,540-15,493 ; ), p = 0,008; OR = 3,4; 95% CI = 1,406- 8,268, p = 0,045; OR = 0,29; CI 95% = 0,91-0,95)Kesimpulan: Faktor yang mempengaruhi kekuatan genggaman tangan pada lansia pada penelitian ini adalah jenis kelamin, status pekerjaan, dan sindrom metabolik.

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<p>Prevalence of Metabolic Syndrome and Association with Grip Strength in Older Adults: Findings from the HOPE Study</p>

Cited by 37 publications

References 55 publications

Possible Sarcopenia and Impact of Dual-Task Exercise on Gait Speed, Handgrip Strength, Falls, and Perceived Health

Possible Sarcopenia and Impact of Dual-Task Exercise on Gait Speed, Handgrip Strength, Falls, and Perceived Health

Association of central obesity and high body mass index with function and cognition in older adults

Sosio-Ekonomi, Sindrom Metabolik terhadap Kekuatan Genggaman Tangan Lansia di Komunitas

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