&lt;p&gt;Polycystic Ovary Syndrome and Pelvic Floor Dysfunction: A Narrative Review&lt;/p&gt;

Naz, Marzieh Saei Ghare; Tehrani, Fahimeh Ramezani; Behroozi-Lak, Tahereh; Mohammadzadeh, Farnaz; Badr, Farhnaz Kholosi; Ozgoli, Giti

doi:10.2147/rru.s249611

Cited by 12 publications

(10 citation statements)

References 75 publications

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“…It is therefore not surprising that the prevalence of infertility in women with PCOS is about 70 to 80% [ 3 ]. PCOS has also been found to increase the risk of miscarriage, anxiety, and depression [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Haslan

Samsulrizal

Zin

et al. 2021

BMC Complement Med Ther

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Background Insulin resistance and hormonal imbalances are key features in the pathophysiology of polycystic ovarian syndrome (PCOS). We have previously shown that Ficus deltoidea var. deltoidea Jack (Moraceae) can improve insulin sensitivity and hormonal profile in PCOS female rats. However, biological characteristics underpinning the therapeutic effects of F. deltoidea for treating PCOS remain to be clarified. This study aims to investigate the biochemical, hormonal, and histomorphometric changes in letrozole (LTZ)-induced PCOS female rats following treatment with F. deltoidea. Methods PCOS was induced in rats except for normal control by administering LTZ at 1 mg/kg/day for 21 days. Methanolic extract of F. deltoidea leaf was then orally administered to the PCOS rats at the dose of 250, 500, or 1000 mg/kg/day, respectively for 15 consecutive days. Lipid profile was measured enzymatically in serum. The circulating concentrations of reproductive hormone and antioxidant enzymes were determined by ELISA assays. Ovarian and uterus histomorphometric changes were further observed by hematoxylin and eosin (H&E) staining. Results The results showed that treatment with F. deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats. The levels of high-density lipoprotein cholesterol (HDL), estrogen, and superoxide dismutase (SOD) are also similar to those observed in normal control rats. Histomorphometric measurements confirmed that F. deltoidea increased the corpus luteum number and the endometrial thickness. Conclusions F. deltoidea can reverse PCOS symptoms in female rats by improving insulin sensitivity, antioxidant activities, hormonal imbalance, and histological changes. These findings suggest the potential use of F. deltoidea as an adjuvant agent in the treatment program of PCOS.

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Section: Introductionmentioning

confidence: 99%

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Haslan

Samsulrizal

Zin

et al. 2021

BMC Complement Med Ther

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“…(10) Another research showed that raise in body mass causes over pressure exertion on bladder and pelvic floor muscles as a result urinary problem symptoms are observed in such cases. (11) Obesity plays a vital role is hormonal imbalance and PCOS it is a predisposing factor for PCOS and their consequences effects major body organs for example Urinary system, body's metabolic system reducing weight will cause improvement in condition. (12) Previous study showed that high BMI and PCOS both are involved in causing urinary incontinence.…”

Section: Discussionmentioning

confidence: 99%

Association of Urinary Incontinence and Body Mass Index with Polycystic Ovary Syndrome

Mian¹,

Mian²,

Ahmed³

et al. 2022

PJMHS

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Background: Polycystic ovary syndrome (PCOS) is a metabolic disorder, which impacts and effects body's multiple system. Female with more fat deposition in her body and higher body mass index (BMI) will eventually face metabolic disorders like polycystic ovary syndrome, diabetes and urinary incontinence (UI). Muscles in the pelvic floor are susceptible and sensitive to androgen and are easily stimulated by presence or increased levels of androgen and due to hyperandrogenemia muscle mass increases and eventually pressure on Levator Ani and urethral sphincter increases and it causes muscle weakness in the pelvic floor and urinary incontinence and patients often complains with urine leakage. Objective: To describe the association between urinary incontinence and the body mass index with polycystic ovary syndrome. Methodology: The study was analytical cross-sectional study. This study included the sample of 113 nulliparous females having age between 18-45 years. Quota sampling technique was used in this study. Participants were divided into two groups, in one group females with diagnosed PCOS were taken and in other quota we had females without PCOS condition. We provided them the International Incontinence Consultation Questionnaire-Short Form (ICIQ-SF), which is a specific questionnaire that assesses the problem of UI symptoms. Results: ICIQ-SF statistics were checked applying chi-square testing. Results showed value less than Alpha value which was 5% (0.05) so, the results were statistically significant and alternate hypothesis was accepted which showed UI and BMI had a significant relation with PCOS. This study will be beneficial in creating awareness among society that endocrine system and body mass index play important role in causing Urinary Incontinence and other health issues. Conclusion: According to this study's findings, there is a strong correlation between UI and BMI with PCOS. Keywords: Urinary incontinence (UI), Body mass index (BMI), Polycystic ovary syndrome (PCOS), International Consultation on Incontinence Questionnaire-Urinary Incontinence (ICIQ-UI), Pelvic Floor Dysfunction (PFD).

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“…Social stigma is a major factor that puts a stop to the regular health visit of women suffering from PFDs especially in a lower economy country where literacy rate is also less. They gradually undergo distress and are despondent until they are revealing their problems [ 33 ]. The reporting of PFDs related diseases is less documented than actually; it persists in the current scenario especially in the rural population of India.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the effect of Mulabandha yoga therapy in healthy women, stigmatized for pelvic floor dysfunctions: A randomized controlled trial

Sweta¹,

Godbole

Prajapati³

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background In developing countries, women do not reveal their perineum related health issues because most of the time they are stigmatized by the society. Multiparity, mostly found in women of rural areas is one of the major causes of pelvic floor dysfunctions (PFDs) like pelvic organ prolapse, urinary incontinence, rectal incontinence, etc. Usually, they visit health centres in the advanced stage of diseases, and then medical treatment is not the only choice left. Many research studies show that yoga practices promote health conditions, contribute to enhancing endurance, flexibility, and muscular strength, and improving quality of life. Objective(s) The study was conducted to assess the impact of Mulabandha yoga therapy (MYT) in healthy woman participants as a preventive measure. Material and methods The study was a prospective and randomized controlled trial. Fifty healthy woman participants were allocated in two groups viz., MYT group and No MYT group. Mulabandha yoga was conducted for the MYT group for 12 weeks. No MYT group was advised not to do yoga. Pelvic floor muscle strength was internally evaluated by employing the PERFECT scheme score (P = power, E = endurance, R = repetitions, F = fast contractions, ECT = every contraction timed). For eligible samples, MYT sessions were held for 12 weeks. Data interpretation was done with SPSS software 20.0 (IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY, USA). Results Fifty healthy woman participants were allocated for analysis. There was no statistically significant difference in between the groups comparison in terms of age, socio-economic status, occupation, education, parity and mode of delivery. PERFECT scheme score significantly improved in participants after 12 weeks of regular MYT. No statistically significant differences were observed between the groups comparison in terms of PERFECT scheme score. Conclusion The current study shows that regular practice of MYT for 12 weeks is a better means to reinforce the strength of pelvic floor muscles in women. This MYT procedure will establish evidence for women who are reluctant towards their pelvic organ-related issues. Women must incorporate the MYT practice in their routine life as a preventive measure to refrain from pelvic floor dysfunctions.

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<p>Polycystic Ovary Syndrome and Pelvic Floor Dysfunction: A Narrative Review</p>

Cited by 12 publications

References 75 publications

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Association of Urinary Incontinence and Body Mass Index with Polycystic Ovary Syndrome

Assessment of the effect of Mulabandha yoga therapy in healthy women, stigmatized for pelvic floor dysfunctions: A randomized controlled trial

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