<p>Plasma Fibrinogen Predicts the Prognosis of Bladder Cancer Patients After Radical Cystectomy</p>

Abstract

Background: This study aimed to determine the potential utility of plasma fibrinogen as a prognostic factor in patients with bladder cancer (BCa) after radical cystectomy (RC). Methods: Patients with BCa who underwent RC from 2014 to 2019 were analyzed retrospectively. The indexes of plasma coagulation and fibrinolysis system factors were collected. Kaplan-Meier survival curves were used to calculate the overall survival (OS) and diseasefree survival (DFS). The prognostic value of plasma fibrinogen was analyzed by using Cox regression model, and a nomogram of BCa based on plasma fibrinogen was generated by R software. Results: Among 145 patients, the optimal cutoff value of plasma fibrinogen was 3.14g/L. High level of plasma fibrinogen was related to the poor prognosis of patients with BCa, and plasma fibrinogen has a more accurate prognostic ability than other plasma coagulation and fibrinolysis system factors. Multivariate Cox regression analysis showed that plasma fibrinogen was an independent predictor of OS (>3.14 vs ≤3.14 HR, 2.58, 95% CI = 1.28-5.23; p = 0.008) and DFS (>3.14 vs ≤3.14 HR, 2.60, 95% CI = 1.20-5.65; p = 0.016), and the nomogram based on plasma fibrinogen had better accuracy and discrimination (area under the curve (AUC): OS = 0.741, DFS = 0.733). Conclusion: Plasma fibrinogen can be used as an independent predictor of OS and DFS for RC patients, and the nomogram based on plasma fibrinogen was a reliable model for predicting the prognosis after RC.

The Albumin-to-Fibrinogen Ratio Independently Predicts Acute Kidney Injury in Infants With Ventricular Septal Defect Undergoing Cardiac Surgery With Cardiopulmonary Bypass

“…Moreover, significantly increased Fib in kidney tissues is observed following AKI (34). Alb and Fib were both reported to be significant prognostic factors in the case of a variety of diseases (35)(36)(37)(38). AFR, an index integrating Alb and Fib, offers a more sensitive reflection of the status of systemic inflammation, blood thrombogenicity, and viscosity when compared with Alb or Fib alone (39).…”

The combination of fibrinogen concentrations and the platelet-to-lymphocyte ratio predicts survival in patients with advanced lung adenocarcinoma treated with EGFR-TKIs

“… 29 Clinical studies have evaluated the prognostic role of fibrinogen in various cancers. 9 , 14 , 30 Regarding lung cancer, Zhong et al. 17 conducted a meta-analysis of 16 studies involving 6881 patients, finding that a plasma fibrinogen concentration of ≥4 g/L portended worse OS.…”

“…Several studies evaluated the prognostic role of fibrinogen in various cancers. 14 – 16 In NSCLC, Zhong et al. 17 reported in a meta-analysis that the plasma fibrinogen level is an independent predictor for overall survival (OS).…”

Prognostic value of preoperative albumin-to-fibrinogen ratio (AFR) in patients with bladder cancer treated with radical cystectomy

“…Besides, fibrinogen (Fib), which synthesized and elevated in cancer patients, could contribute to tumor cell proliferation and invasion [9]. Additionally, hypercoagulation status including high fibrinogen is reported to be associated with poor prognosis in BC and other urological cancers [10][11][12]. However, not all patients develop nutritional and coagulation disorders simultaneously.…”