<p>Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases</p>

Abstract

Cardiovascular diseases (CVDs) are one of the foremost causes of high morbidity and mortality globally. Preventive, diagnostic, and treatment measures available for CVDs are not very useful, which demands promising alternative methods. Nanoscience and nanotechnology open a new window in the area of CVDs with an opportunity to achieve effective treatment, better prognosis, and less adverse effects on non-target tissues. The application of nanoparticles and nanocarriers in the area of cardiology has gathered much attention due to the properties such as passive and active targeting to the cardiac tissues, improved target specificity, and sensitivity. It has reported that more than 50% of CVDs can be treated effectively through the use of nanotechnology. The main goal of this review is to explore the recent advancements in nanoparticle-based cardiovascular drug carriers. This review also summarizes the difficulties associated with the conventional treatment modalities in comparison to the nanomedicine for CVDs.

Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside

“…Radioprotective agents may interfere with the anti-cancer effects of RT. Therefore, the development of cardiac-specific drug delivery techniques (e.g., liposomes, polymeric micelles, biodegradable nanoparticles, dendrimers, exosomes, plasmids, or other vectors) [ 163 ]. would be of interest in order to selectively protect the heart from ionizing radiation and thus preventing RIHD.…”

Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases

“…Exosomes have been synthesized naturally within the body and promote cell–cell communication, molecular therapy for cancer treatment ( 212 ), and in the diagnostics of various skeletal disorders, such as osteoarthritis ( 213 ), Osteochondral regeneration ( 214 ), myocardial I/R injury ( 162 ), limb ischemia, and pulmonary hypertension ( 215 ). Exosomes have been explored widely to act as the natural drug delivery vehicles, because they can travel safely in extracellular fluids trespassing immune cells and deliver the cargo to designated target cells with both utmost efficiency and a high degree of specificity ( 216 , 217 ).…”

Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action

“…125,[136][137][138][139][140][141][142] The use of nanoparticles in drug delivery such as polylactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), liposomal delivery systems and RNA-based delivery offers several advantages including 1) improving ease of adsorption, 2) selective targeting, 3) simple encapsulation, 4) enhanced bioavailability, and 5) reduced adverse effects and 6) improved stability for CVDs. 143 These new delivery systems offer many options for achieving tissue selectivity and reduced system exposure required to deploy new pharmacological compounds derived from nutritional fruits for better treatment of CVDs (Figure 10).…”