<p>Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review</p>

Abstract

Extramedullary plasmacytoma (EMP) is an infrequent form of plasma cell dyscrasia that presents as a mass of monoclonal plasma cells located in extramedullary soft tissues with no skeletal component. EMP constitutes ~4% of all plasma cell neoplasms and occurs mostly in the upper respiratory tract. Here, we report a rare case of multiple EMPs involving the trachea, laryngopharynx, and oropharynx, which caused symptoms of airway obstruction as the only clinical manifestation. The patient was diagnosed by histopathology of the tissue from bronchoscopic resection and successfully managed with bronchoscopic intervention to treat lesions in the trachea and radiotherapy combined with surgical resection to treat lesions in the pharynx. There was no recurrence after 14 months of follow-up. Endoscopic intervention plays a key role in the rapid diagnosis and treatment of EMP involving the central airways.

Pleural plasmacytomas in a patient with multiple myeloma relapse

“…Malignant myelomatous pleural effusion caused by the infiltration of pleural fluid by malignant plasma cells is seen in less than 1% of cases and may develop due to the extension of plasmacytomas of the chest wall, invasion from adjacent skeletal lesions, or lymphatic obstruction secondary to lymph node infiltration. It may also develop due to the direct implantation of tumor nodules on the pleura, i.e., pleural plasmacytomas [ 7 , 8 ].…”

Radical resection of solitary tracheal extramedullary plasmacytoma under non-intubated anesthesia: a case report

“…During the 6-month follow-up period, our patients showed a satisfactory clinical response to surgical intervention without recurrence. Given that the conversion risk is the highest in the first 2 years, longterm follow-up is mandatory (20).…”

Multiple Upper Aerodigestive Tract Masses Presenting With Stridor—A Rare Case of Aggressive Multifocal Extramedullary Plasmacytoma

“…6 The etiology is still unclear, but chronic irritation and viral infection may have a role in pathogenesis. 7 To differentiate EMP from multiple myeloma, reactive plasmacytosis, immunoblastic lymphoma, and plasma cell granuloma, the analysis of bone marrow aspirate may be needed in addition to histopathological analysis. Bence-Jones protein is present in 16% of cases of EMP and 25% will have a positive myeloma screen.…”