&lt;p&gt;Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19&lt;/p&gt;

Ren, Xiaohan; Wang, Shangqian; Chen, Xinglin; Wei, Xiao‐Hong; Li, Guangyao; Ren, Shancheng; Zhang, Tongtong; Zhang, Xu; Lù, Zhongwen; You, Zebing; Wang, Zengjun; Song, Na; Qin, Chao

doi:10.2147/idr.s270543

Cited by 32 publications

(21 citation statements)

References 57 publications

(25 reference statements)

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“…For example, the functional overexpression of MX1 was a significantly mediated anti-viral response both to SARS-CoV and to SARS-CoV-2 [35,36]. Elevated expression levels of IL-8 and IL-36G have been declared to be closely related to COVID-19 severity [11,79].…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, Xiong et al conducted a transcriptome sequencing of the RNAs isolated from bronchoalveolar lavage fluid as well as peripheral blood mononuclear cell (PBMC) samples of COVID-19 patients. Their results revealed host inflammatory cytokine profiles to SARS-CoV-2 infection in patients and highlighted the association between COVID-19 pathogenesis and excessive cytokine releases such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B [11]. In another study, Ren et al used single-cell RNA sequencing (scRNA-seq) analysis to evaluate the expression and distribution of angiotensinconverting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS) genes in kidney cell components.…”

Section: Introductionmentioning

confidence: 93%

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Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection

Karami

Derakhshani

GhasemiGol

et al. 2021

JCM

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The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives. Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless, as of today, no effective drug exists for COVID-19. The identification of key genes and pathways in this disease may lead to finding potential drug targets and biomarkers. Here, we applied weighted gene co-expression network analysis and LIME as an explainable artificial intelligence algorithm to comprehensively characterize transcriptional changes in bronchial epithelium cells (primary human lung epithelium (NHBE) and transformed lung alveolar (A549) cells) during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our study detected a network that significantly correlated to the pathogenicity of COVID-19 infection based on identified hub genes in each cell line separately. The novel hub gene signature that was detected in our study, including PGLYRP4 and HEPHEL1, may shed light on the pathogenesis of COVID-19, holding promise for future prognostic and therapeutic approaches. The enrichment analysis of hub genes showed that the most relevant biological process and KEGG pathways were the type I interferon signaling pathway, IL-17 signaling pathway, cytokine-mediated signaling pathway, and defense response to virus categories, all of which play significant roles in restricting viral infection. Moreover, according to the drug–target network, we identified 17 novel FDA-approved candidate drugs, which could potentially be used to treat COVID-19 patients through the regulation of four hub genes of the co-expression network. In conclusion, the aforementioned hub genes might play potential roles in translational medicine and might become promising therapeutic targets. Further in vitro and in vivo experimental studies are needed to evaluate the role of these hub genes in COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection

Karami

Derakhshani

GhasemiGol

et al. 2021

JCM

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“…There are obvious sex differences in reproductive complication and sequelae. Recent studies had confirmed ACE2 is abundant in gametocytes, Sertoli cells and spermatogonia stem cells, suggesting the testis is a high-risk organ vulnerable to 2019-nCoV infection (90,91). Indeed, coronavirus could damage the structure of the testicles and affect male fertility, supported by the detection of coronavirus in the semen of patients, some of whom had complication of orchitis ( 92).…”

Section: Reproductive Complicationmentioning

confidence: 98%

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

et al. 2021

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COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in addition to respiratory symptoms. Controlling the epidemic is only a phased victory, and the complication and sequelae of COVID-19 will need more attention in the post-epidemic era. We collected general information from over 1000 articles published in 2020 after the COVID-19 outbreak and systematically analyzed the complication and sequelae associated with eight major systems in COVID-19 patients caused by ACE2 intervention in the RAS regulatory axis. The autoimmune response induced by 2019-nCoV attacks and damages the normal tissues and organs of the body. Our research will help medical workers worldwide address COVID-19 complication and sequelae.

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“…Several studies attempted to gain new insights into the pathogenic mechanisms of SARS-CoV-2 underlying this clinical manifestation in the kidney. Notably, receptors for proinflammatory cytokines, especially IL6ST, were found to be concentrated in renal endothelial cells, which suggests the occurrence of alternative damaging autoimmune mechanisms [12].…”

Section: The Well-known Ace Role and Its Controversial Involvementmentioning

confidence: 99%

“…Conversely, it was suggested that ACE2 has the potential of slowing the progression of experimental diabetic chronic kidney disease [11], and it was found to be highly and significantly expressed in the kidney among individuals with chronic kidney diseases or DN [12].…”

Section: The Well-known Ace Role and Its Controversial Involvementmentioning

confidence: 99%

Diabetic Nephropathy and COVID-19: The Potential Role of Immune Actors

Mourad

Azar

2021

IJMS

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Nowadays, type II diabetes mellitus, more specifically ensuing diabetic nephropathy, and severe COVID-19 disease are known to be closely associated. The exact mechanisms behind this association are less known. An implication for the angiotensin-converting enzyme 2 remains controversial. Some researchers have started looking into other potential actors, such as neuropilin-1, mitochondrial glutathione, vitamin D, and DPP4. In particular, neuropilin-1 seems to play an important role in the underlying mechanism linking COVID-19 and diabetic nephropathy. We suggest, based on the findings in this review, that its up-regulation in the diabetic kidney facilitates viral entry in this tissue, and that the engagement of both processes leads to a depletion of neuropilin-1, which was demonstrated to be strongly associated with the pathogenesis of DN. More studies are needed to confirm this hypothesis, and research should be directed towards elucidating the potential roles of all these suggested actors and eventually discovering new therapeutic strategies that could reduce the burden of COVID-19 in patients with diabetic nephropathy.

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<p>Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19</p>

Cited by 32 publications

References 57 publications

Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection

Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

Diabetic Nephropathy and COVID-19: The Potential Role of Immune Actors

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