<p>Minimal Clinically Important Difference in Barthel Index Dyspnea in Patients with COPD</p>

Abstract

Background: The Barthel Index dyspnea (BId) is responsive to physiological changes and pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, the minimum clinically important difference (MCID) has not been established yet. Aim: To identify the MCID of BId in patients with COPD stratified according to the presence of chronic respiratory failure (CRF) or not. Materials and Methods: Using the Medical Research Council (MRC) score as an anchor, receiver operating characteristic curves and quantile regression were retrospectively evaluated before and after pulmonary rehabilitation in 2327 patients with COPD (1151 of them with CRF). Results: The median post-rehabilitation changes in BId for all patients were −10 (interquartile range = −17 to −3, p<0.001), correlating significantly with changes in MRC (r = 0.57, 95% CI = 0.53 to 0.59, p<0.001). Comparing different methods of assessment, the MCID ranged from −6.5 to −9 points for patients without and −7.5 to −12 points for patients with CRF. Conclusion: The most conservative estimate of the MCID is −9 points in patients with COPD, without and −12 in those with CRF. This estimate may be useful in the clinical interpretation of data, particularly in response to intervention studies.

Feasibility of tele-rehabilitation in survivors of COVID-19 pneumonia

“…On admission to TR, anthropometrics, clinical status and lung function were collected ( Table 1 ). On admission and discharge, 6MWT, 8 1 min Sit-to-Stand (1MSTS), 10 and Barthel Dyspnoea Index 11 were assessed. Program adherence (i.e.…”

“… 10 Barthel dyspnoea improved in 83.3%, remaining unchanged in 16.7% of patients; in 50% of patients, the dyspnoea decrease was 6.5 points above the MCID. 11 …”

Ambulatory oxygen therapy with documented self-monitoring of oxygen use improves health status among patients with chronic obstructive pulmonary disease

“…The participants reported improvements in the mobility, self-care, and routine activity domains of the EQ-5D. The total and respiratory symptom domains of the CAT also improved in magnitude by more than the minimal clinically important difference (16). The CAT is a short, simple assessment tool for evaluating the symptom burden of COPD in daily clinical practice to check health status assessment and communicate between patients and healthcare providers.…”

Time course of exercise capacity in patients recovering from COVID-19-associated pneumonia

“…A reduction of 9 and 12 points is considered as the minimal clinically important difference in COPD patients without and with chronic respiratory failure, respectively. 26 Perceived health status was measured by the Euro Quality of Life Visual Analogue Scale. 27 Total scores range from 0 to 100 (higher scores represent better quality of life).…”