&lt;p&gt;&lt;em&gt;Citrus limon&lt;/em&gt; Peel Essential Oil–Induced Type IV Hypersensitivity Reaction&lt;/p&gt;

Mahdani, Fatma Yasmin; Parmadiati, Adiastuti Endah; Ernawati, Diah Savitri; Husain, Hasrul; Ekaperdana, Sekar Alifa Putri; Rachmaningayu, Ulyasari; Hadi, Priyo; Hendarti, Hening Tuti; Surboyo, Meircurius Dwi Condro

doi:10.2147/jep.s256139

Cited by 6 publications

(7 citation statements)

References 17 publications

(19 reference statements)

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“…This condition occurred by the possibility of antigens that have been eliminated and are also caused by the activity of essential oil compounds in both suppressing the inflammatory response to increase the anti-inflammatory effect on the body or as an immunostimulant to increase the body's defence through phagocytosis. This finding is consistent with a previous study, which may be related to the activity of antiinflammatory cytokines in Citrus limon peel essential oil 16 .…”

Section: Discussionsupporting

confidence: 94%

“…To obtain 100% pure Citrus limon peel essential oil, Citrus limon originating from Lawang, East Java was steamdistilled in the Chemistry Laboratory of the Faculty of Science and Technology, Universitas Airlangga. The Gas Chromatography-Mass Spectrometry (GC-MS) test was conducted on Citrus limon peel essential oil 100% before the type IV hypersensitivity test to determine the compounds contained therein 16 . Using 3% Carboxyl Methyl Cellulose-Sodium (CMC-Na) powder, the Citrus limon peel essential oil 100% is diluted to achieve concentrations of 0.39%, 0.78%, and 1.56% before being made into a gel.…”

Section: Citrus Limon Peels Essential Oil Gel Makingmentioning

confidence: 99%

“…Based on the GC-MS test conducted, there were 24 compounds contained in the Citrus limon peel essential oil. Compounds with the highest percentage include D-limonene (75.02%), Linalool (5.63%), E-citral (4.41%), Z-citral (3.68%), and other compounds with a percentage below 1% 16 .…”

Section: Gas Chromatography-mass Spectrometrymentioning

confidence: 99%

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Topical Application of <i>Citrus limon</i> Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction

Mahdani

Rachmaningayu

Anjani

et al. 2023

IJMDS

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Introduction: Citrus limon peels essential oil has the potential to be developed as a topical medicine due to its active components. The essential oil has been demonstrated in numerous studies to have anti-inflammatory, anti-microbial, antifungal, and antioxidant properties. A study is required to determine whether Citrus limon peel essential oil can cause a type IV hypersensitivity reaction by examining the expression of the cytokines TNF-, IL-1, and IL-6 as well as the clinical manifestations on an animal skin. In this study, the effect of topically applying the essential oil of Citrus limon peel on the expression of TNF-α, IL-1, and IL-6 as well as on type IV hypersensitivity reaction symptoms was examined. Methods: This study is based on the guinea-pig maximisation test method in NADFC RI Regulation Number 7 of 2014, with two groups (control group and treatment group) for each set of ten samples. Citrus limon peels essential oil was administered to the treatment group, whereas CMC-Na was given to the control group. Animal models were euthanized after which the tissues were prepared as specimens for immunohistochemical staining. The expression of cytokines was computed and examined using a light microscope. Results: There were no clinical signs of type IV hypersensitivity in either group, and the expression of TNF-α, IL-1 and IL-6 in the treatment group was found higher than in the control group. Conclusion: After topical administration of Citrus limon peels essential oil, there was an increase in the expression of TNF-α, IL-1 and IL-6 without any clinical symptoms of type IV hypersensitivity.

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Section: Discussionsupporting

confidence: 94%

Section: Citrus Limon Peels Essential Oil Gel Makingmentioning

confidence: 99%

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Topical Application of <i>Citrus limon</i> Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction

Mahdani

Rachmaningayu

Anjani

et al. 2023

IJMDS

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“…Phillip Gell and Robin Coombs, two Brit-ish immunologists, created this categorization in the early 1960s [3] . There are four different categories of hypersensitivity reactions, according to Gell-Coomb hypersensitivity labels (Figure 1) [4][5][6][7] :…”

Section: Introductionmentioning

confidence: 99%

Novel approaches for allergen-specific immunotherapy—An overview

Sakshi,

Mazumder,

Monika

et al. 2023

Trends Immunother

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Allergen-specific immunotherapy (AIT) is an allergen-specific treatment for people with IgE-related allergies. Allergen-specific immunotherapy (AIT) is used to treat allergic disorders when symptoms persist despite medication and allergen avoidance. The therapy is presumed effective if it reduces the use of medications, improves the quality of life even after discontinuation of treatment, as well as prevents the conversion of one type of allergy to the other and the development of new sensitization. The allergen-specific immunotherapeutic agents can be administered sublingually, subcutaneously, or through some other routes, such as intra-lymphatically and epicutaneously to induce allergen tolerance by modifying immune responses (innate and adaptive). The primary mechanism of AIT is the induction of functional regulatory cells, such as regulatory T cells, follicular T cells, B cells, dendritic cells, innate lymphoid cells, and natural killer cells, which results in the control of the functions of type 2 inflammatory cells. However, there are several downsides to AIT, including the contentious treatment period resulting in high cost, systemic allergic reactions, and the lack of a biomarker for forecasting treatment responders. Vaccine adjuvants, adjunctive therapies, and novel vaccine technologies are currently being researched to address the issues associated with AIT. This article focuses on defined molecular approaches for improving the potential of specific immunotherapy that use recombinant allergen derivatives, allergen-derived peptides, virus-coupled allergens, nanoparticles, and specific adjuvants.

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“…En la actualidad, la alergia a las frutas cítricas ha sido poco estudiada, se ha documentado la existencia de alergenos que promueven reacciones de hipersensibilidad de tipo 1 y de tipo 4 16 . Estos alergenos pertenecen a la familia de proteínas de transporte de lípidos, y fueron encontrados en la naranja y el limón 17 .…”

Section: Introductionunclassified

Efectos en la salud asociados a la ingesta de frutas cítricas en infantes de 6 a 24 meses de edad: Protocolo de una revisión sistemática

Daga

Gomez-Rutti

Soto-Pascual

et al. 2022

Rev Esp Nutr Hum Diet

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Introducción: En América Latina, las recomendaciones sobre la introducción de frutas cítricas en la alimentación complementaria son heterogéneas. La restricción de alimentos durante los primeros años de vida puede incrementar el riesgo de tener deficiencias nutricionales. El objetivo de la revisión es identificar los efectos en la salud asociados a la ingesta de frutas cítricas en infantes de 6 a 24 meses de edad. Metodología: Se incluirán a estudios que tengan como población a infantes nacidos pretérmino, sin enfermedades o intervenciones quirúrgicas que demanden de la modificación de la dieta. Se considera como frutas cítricas a la Naranja, Camu Camu, Tangelo, Limón, Mandarina, Lima, Sidra, Pomelo y Clementina, consumidas en su forma natural o en jugos o extractos, o en combinación con otros alimentos. Se reportarán todos los efectos en la salud asociados a la ingesta de frutas cítricas. Se realizarán búsquedas en MEDLINE (a través de PubMed), SCOPUS, LILACS, SciELo, Epistemonikos, y CENTRAL. También, se realizarán búsquedas de literatura gris en repositorios de tesis internacionales. Se incluirán a estudios observacionales, ensayos clínicos aleatorizados y no aleatorizados. La selección de estudios, extracción de datos y evaluación de riesgo de sesgo se realizará de forma independiente, por duplicado y con cegamiento. Al culminar cada etapa, se levantará el cegamiento para resolver los conflictos entre los revisores mediante el consenso. Se realizará una síntesis narrativa de los resultados de los estudios primarios y el riesgo de sesgo. Ética y diseminación: El protocolo está registrado en PROSPERO: CRD42021230561.

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<p><em>Citrus limon</em> Peel Essential Oil–Induced Type IV Hypersensitivity Reaction</p>

Cited by 6 publications

References 17 publications

Topical Application of <i>Citrus limon</i> Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction

Topical Application of <i>Citrus limon</i> Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction

Novel approaches for allergen-specific immunotherapy—An overview

Efectos en la salud asociados a la ingesta de frutas cítricas en infantes de 6 a 24 meses de edad: Protocolo de una revisión sistemática

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