&lt;p&gt;&lt;em&gt;Chlamydia&amp;nbsp;trachomatis&lt;/em&gt; infection in primary fallopian tube and high-grade serous ovarian cancers: a pilot study&lt;/p&gt;

Laban, Mohamed; Ibrahim, Eman; Hassanin, Alaa S.; Nasreldin, Magda H. A.; Mansour, Amal; Khalaf, Waleed M.; Eldin, Ahmed M Bahaa; Hussain, Sherif Hanafi; Elsafty, Mohammed S.E.; Hasanien, Ahmad S

doi:10.2147/ijwh.s188938

Cited by 7 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chlamydia trachomatis was detected in 80% of EOC cases, which is consistent with prior research [26,31,56]. In fact, researchers have found C. trachomatis in 84% of high-grade fallopian tube serous cancers and in 17% of HGSOCs [57]. This evidence corroborates the negative impact of chlamydial infection on fallopian tube health particularly as HGSOC, the most lethal EOC histotype, originates within the fallopian tube [38].…”

Section: Discussionsupporting

confidence: 88%

The role of microbiota in epithelial ovarian cancer: a scoping review

Mahoney¹,

Petersen²,

Spoozak³

et al. 2021

EJGO

View full text Add to dashboard Cite

The objective of this review was to examine the comprehensive role of microbiota in epithelial ovarian carcinogenesis. Methods: A scoping review method was used, and relevant databases were searched using combinations of key terms. Human and animal studies were selected that met inclusion criteria and critical appraisal tools were used to assess study quality. Results: A total of 10 international studies (human n = 8; animal n = 2) were included with total samples sizes varying from 16 to 580. Mean/median ages of women with epithelial ovarian cancer (EOC) were 50.5 to 66 years, and controls were 47.3 to 56 years. Compared to the ovaries and fallopian tubes of women without disease, tissue collected from women with EOC were characterized by differing proportions of bacterial phyla including Actinobacteria, Bacteroidetes, Chlamydiae, Firmicutes, and Proteobacteria. Intestinal depletions and reduced diversity of genera Lactobacillus accelerated ovarian tumor growth in animal models. Cytomegalovirus and human papillomavirus types 6, 16, 18, and 45 had a significantly higher prevalence in women with disease and represented up to 70% of cases with high-grade serous ovarian carcinoma. Colonized bacteria were detected in fallopian tubes, peritoneal fluid, and ovarian tissue similar to that of commensal GI tract and vaginal bacteria. Conclusion: The EOC microenvironment harbors diverse microbes. Due to the heterogeneity of microbiota identified between studies, additional research is needed to reconcile findings and ascertain clinical applicability. Future investigations should also examine potential associations between EOC tumor, gut, and vaginal microbiota, patient symptoms throughout disease, chemotherapy response, recurrence, and survival.

show abstract

Section: Discussionsupporting

confidence: 88%

The role of microbiota in epithelial ovarian cancer: a scoping review

Mahoney¹,

Petersen²,

Spoozak³

et al. 2021

EJGO

View full text Add to dashboard Cite

show abstract

“…Based on the abovementioned, C. trachomatis has been implicated in ovarian cancer development [[16], [17], [18]]. Antibodies to C. trachomatis and chsp60 is associated with pelvic inflammatory disease (PID) [19,20].…”

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatis and Anti-MUC1 Serology and Subsequent Risk of High-Grade Serous Ovarian Cancer: A Population-Based Case–Control Study in Northern Sweden

Jonsson

Lundin

Elgh

et al. 2020

Translational Oncology

View full text Add to dashboard Cite

BACKGROUND:Chlamydia trachomatis salpingitis causes inflammatory damage to the fallopian tube and could potentially cause initiation and progression of high-grade serous ovarian cancer (HGSC). Furthermore, C. trachomatis infection may stimulate mucin 1 (MUC1) protein production, possibly affecting anti-MUC1 antibody levels. The aim of this study was to examine if serology indicating past infection with C. trachomatis as well as anti-MUC1 production was associated with subsequent risk of HGSC. MATERIALS AND METHODS: In a prospective nested case–control study within the Northern Sweden Health and Disease Study and the Northern Sweden Maternity Cohort, the prevalence of chlamydial and anti-MUC1 antibodies was analyzed in blood samples drawn more than one year before diagnosis from 92 women with HGSC and 359 matched controls. Matching factors were age, date at blood draw, and sampling cohort. Plasma C. trachomatis IgG was analyzed using commercial micro-immunofluorescence test; chlamydial Heat Shock Protein 60 IgG (cHSP60) and anti-MUC1 IgG were analyzed with ELISA technique. RESULTS: The prevalence of C. trachomatis IgG and cHSP60 IgG antibodies, as well as the level of anti-MUC1 IgG was similar in women with HGSC and controls (16.3% vs. 17.0%, P = 0.87; 27.2% vs. 28.5%, P = 0.80; median 0.24 vs. 0.25, P = 0.70). Anti-MUC1 IgG and cHSP60 IgG levels were correlated (r = 0.169; P < 0.001). CONCLUSIONS: The findings of this prospective nested case–control study did not support an association between C. trachomatis infection, as measured by chlamydial serology, or anti-MUC1 IgG antibodies, and subsequent risk of HGSC.

show abstract

“…Recently, it has been shown that C . trachomatis DNA is highly expressed in tubal serous cancer compared with high-grade serous ovarian cancer 26 . Some reports confirmed the presence of human papilloma virus (HPV) in malignant ovarian cancer 25,27–34 , while others did not 35–38 .…”

Section: Introductionmentioning

confidence: 99%

Detection and genotyping of CMV and HPV in tumors and fallopian tubes from epithelial ovarian cancer patients

Paradowska

Jabłońska

Studzińska

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Viral and bacterial infections are detected in epithelial ovarian cancer (EOC) tissues. Since the fallopian tubes are often affected by pelvic inflammatory disease (PID) and the majority of serous EOCs appear to originate from dysplastic lesions in the distal tube, it is relevant to consider the potential role that infectious agents may play in ovarian carcinogenesis. We sought to analyze the prevalence of human papillomavirus (HPV) and cytomegalovirus (CMV) in EOC tissue and fallopian tube specimens obtained at tumor resection. Ovarian cancer and fallopian tube tissue samples obtained from patients with EOC were analyzed by both qualitative and quantitative PCR to detect and quantify viral DNA. The presence of CMV and HPV DNA was detected in 70% and 74% cancerous ovarian tissues, respectively, and was significantly higher in EOC than in benign tumor cases (P ≤ 0.01). CMV or HPV infection was observed also in the fallopian tube samples. Infection with HPV16 was determined in 70% of EOC cases. Almost two thirds of EOC patients demonstrated coinfection with CMV and HPV in the pathological samples. The results revealed that the presence of CMV and HPV in EOC samples is common. CMV and HPV infections can be potential risks for EOC development.

show abstract

<p><em>Chlamydia trachomatis</em> infection in primary fallopian tube and high-grade serous ovarian cancers: a pilot study</p>

Cited by 7 publications

References 22 publications

The role of microbiota in epithelial ovarian cancer: a scoping review

The role of microbiota in epithelial ovarian cancer: a scoping review

Chlamydia trachomatis and Anti-MUC1 Serology and Subsequent Risk of High-Grade Serous Ovarian Cancer: A Population-Based Case–Control Study in Northern Sweden

Detection and genotyping of CMV and HPV in tumors and fallopian tubes from epithelial ovarian cancer patients

Contact Info

Product

Resources

About