The MARCH family of proteins are membrane-associated E3 ubiquitin ligases that down-regulate surface membrane proteins. Expression of MARCH8 in cells causes the ubiquitination and down-regulation of surface CD98 and CD44—cargo proteins that enter cells by clathrin-independent endocytosis and are usually routed to recycling, not degradation.

• Homologous recombination (HR) proficient high-grade serous ovarian cancers (HGSOC) are associated with poor clinical outcomes. • About 30% of HGSOCs have amplifications in CCNE1 and/or BRD4 and 8% have co-amplifications in CCNE1 and BRD4. • CCNE1 and BRD4 amplifications are associated with increased protein expression in HGSOC. • Elevated cyclin E protein expression by immunohistochemistry is associated with platinum resistance.

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