&lt;p&gt;lncRNAs as potential molecular biomarkers in the clinicopathology and prognosis of cholangiocarcinoma: a systematic review and meta-analysis&lt;/p&gt;

Dai, Kangfu; Quan, Jing; Yan, Fangli; Jin, Xinghan; Pan, Xiang; Song, Xiaorui; Zhang, Shijie; Ren, Qingqi; Liu, Jikui; Li, Xiaoping

doi:10.2147/ott.s188134

Cited by 9 publications

(9 citation statements)

References 43 publications

(102 reference statements)

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“…Secondly, besides mRNA, the predictive value of microRNA, lncRNA, and CpG in tumor prognosis had been validated. Multi-dimensional data analysis integrated with mRNA, microRNA, lncRNA, CpG might further increase the predictive efficiency [42][43][44]. Finally, cell functions and molecule mechanisms for the 7 mRNAs had not been explored in our study.…”

Section: Discussionmentioning

confidence: 97%

Prognostic values of a novel multi-mRNA signature for predicting relapse of cholangiocarcinoma

et al. 2020

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Cholangiocarcinoma (CCA) is an epithelial cancer and has high death and recurrence rates, current methods cannot satisfy the need for predicting cancer relapse effectively. So, we aimed at conducting a multi-mRNA signature to improve the relapse prediction of CCA. We analyzed mRNA expression profiling in large CCA cohorts from the Gene Expression Omnibus (GEO) database (GSE76297, GSE32879, GSE26566, GSE31370, and GSE45001) and The Cancer Genome Atlas (TCGA) database. The Least absolute shrinkage and selection operator (LASSO) regression model was used to establish a 7-mRNA-based signature that was significantly related to the recurrence-free survival (RFS) in two test series. Based on the 7-mRNA signature, the cohort TCGA patients could be divided into high-risk or low-risk subgroups with significantly different RFS [p < 0.001, hazard ratio (HR): 48.886, 95% confidence interval (CI): 6.226-3.837E+02]. Simultaneously, the prognostic value of the 7-mRNA signature was confirmed in clinical samples of Ren Ji hospital (p < 0.001, HR: 4.558, 95% CI: 1.829-11.357). Further analysis including multivariable and subgroup analyses revealed that the 7-mRNA signature was an independent prognostic value for recurrence of patients with CCA. In conclusion, our results might provide an efficient tool for relapse prediction and were beneficial to individualized management for CCA patients.

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Section: Discussionmentioning

confidence: 97%

Prognostic values of a novel multi-mRNA signature for predicting relapse of cholangiocarcinoma

et al. 2020

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“…A fixed-effects or random-effects model was applied to evaluate the prognostic value of Tiam1 expression and its association with lymphatic metastasis. A fixed-effects model was chosen when there was no obvious heterogeneity among studies 38 Otherwise, a random-effects model was used. Begg's test 39 and Egger's test 40 were employed to assess the publication bias.…”

Section: Discussionmentioning

confidence: 99%

<p>High Tiam1 expression predicts positive lymphatic metastasis and worse survival in patients with malignant solid tumors: a systematic review and meta-analysis</p>

Yang

et al. 2019

OTT

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Background: Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognostic value of Tiam1 expression and its association with lymphatic metastasis in malignant solid tumors. Methods: We searched eligible studies in PubMed, Web of Science and EMBASE databases (from inception up to October 2018). The combined HR with 95% CI was used to estimate the prognostic value of Tiam1 expression. The correlation between Tiam1 expression and lymphatic metastasis was assessed using the combined odds ratio (OR) with 95% CI. Results: A total of 17 studies with 2,228 patients with solid tumors were included in this meta-analysis. The overall estimated results showed that high Tiam1 expression was significantly associated with shorter overall survival (HR= 2.08, 95% CI: 1.62-2.68, P<0.01), and disease-free survival (HR = 1.86, 95% CI: 1.49-2.32, P<0.01). Besides, we also found that there was a close relationship between high Tiam1 expression and positive lymphatic metastasis (OR=2.63; 95% CI: 1.79-3.84, P<0.01). Conclusion: High Tiam1 expression was significantly associated with shorter survival and positive lymphatic metastasis in patients with malignant solid tumors. Therefore, Tiam1 may be a promising prognostic biomarker and an effective therapeutic target for malignant solid tumors.

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“…The prognosis for patients with CCA is abysmal due to late diagnosis and tumor resistance to chemotherapy and radiotherapy, emphasizing the need for new therapeutic targets and novel biomarkers [ 59 ]. Sun et al, reported that KCNQ1OT1 was highly expressed in CCA tissues and cells, and its overexpression was correlated with poor survival in CCA patients [ 27 ].…”

Section: Kcnq1ot1 In Human Cancersmentioning

confidence: 99%

KCNQ1OT1: An Oncogenic Long Noncoding RNA

Cagle

Niture

et al. 2021

Biomolecules

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Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) encodes a lncRNA from the opposite strand of KCNQ1 in the CDKN1C/KCNQ1OT1 cluster that is reported to play a vital role in the development and progression of cancer. KCNQ1OT1 regulates cancer cell proliferation, cell cycle, migration and invasion, metastasis, glucose metabolism, and immune evasion. The aberrant expression of KCNQ1OT1 in cancer patients is associated with poor prognosis and decreased survival. This review summarizes recent literature related to the biological functions and molecular mechanisms of KCNQ1OT1 in various human cancers, including colorectal, bladder, breast, oral, melanoma, osteosarcoma, lung, glioma, ovarian, liver, acute myeloid leukemia, prostate, and gastric. We also discuss the role of KCNQ1OT1 as a promising diagnostic biomarker and a novel therapeutic target in human cancers.

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<p>lncRNAs as potential molecular biomarkers in the clinicopathology and prognosis of cholangiocarcinoma: a systematic review and meta-analysis</p>

Cited by 9 publications

References 43 publications

Prognostic values of a novel multi-mRNA signature for predicting relapse of cholangiocarcinoma

Prognostic values of a novel multi-mRNA signature for predicting relapse of cholangiocarcinoma

<p>High Tiam1 expression predicts positive lymphatic metastasis and worse survival in patients with malignant solid tumors: a systematic review and meta-analysis</p>

KCNQ1OT1: An Oncogenic Long Noncoding RNA

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