&lt;p&gt;lncRNA MT1JP Suppresses Biological Activities of Breast Cancer Cells in vitro and in vivo by Regulating the miRNA-214/RUNX3 Axis&lt;/p&gt;

Ouyang, Qianwen; Cui, Yanru; Yang, Shi‐Ming; Wei, Wensong; Zhang, Mingyue; Zeng, Jie; Qü, Fei

doi:10.2147/ott.s241503

Cited by 10 publications

(8 citation statements)

References 37 publications

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“…Similar findings have been reported in breast cancer cells ( Ouyang [ 57 ]). Importantly, levels of RUNX3 and P21 were noticed to be significantly upregulated, whereas levels of MMP2 and MMP9 were found to be downregulated in MT1JP- overexpressing-Bel-7402 and Huh-7 cancer cells ( Mo [ 58 ]).…”

Section: Interplay Between Lncrnas and Runx1supporting

confidence: 90%

Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

Farooqı

Kapanova

Mukhanbetzhanovna

et al. 2021

Non-coding RNA Research

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RUNX proteins have been shown to behave as “double-edge sword” in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional regulation of different cell signaling pathways. Several new mechanistic insights and distinct modes of cross-regulation of RUNX proteins and non-coding RNAs have been highlighted by recent research. In this review we have attempted to provide an intricate interplay between non-coding RNAs and RUNX proteins in different cancers. Better conceptual and mechanistic understanding of layered regulation of RUNX proteins by non-coding RNAs will be helpful in effective translation of the laboratory findings to clinically effective therapeutics.

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Section: Interplay Between Lncrnas and Runx1supporting

confidence: 90%

Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

Farooqı

Kapanova

Mukhanbetzhanovna

et al. 2021

Non-coding RNA Research

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“… 22 LncRNA MT1JP sponges miR-214 to inhibit breast cancer progression. 23 DDX11-AS1 has also been reported to sponge several miRNAs, such as miR-499b-5p, miR-873, and miR-326. 13 , 14 , 19 In our study, we found that DDX11-AS1 was distributed in the cytoplasm of glioma cells.…”

Section: Discussionmentioning

confidence: 99%

LncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis

Zheng¹,

Xie²,

Xu³

et al. 2021

OTT

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Background: Long noncoding RNAs (lncRNA) exert essential functions during tumorigenesis. However, how lncRNAs participate in glioma development remains poorly researched. This study aimed to determine how DDX11-AS1 affects glioma progression. Methods: Gene expression was analyzed by qRT-PCR. Survival rate curve was plotted in 56 glioma patients. Loss-of-function assays were performed to analyze proliferation, migration, and invasion through CCK8, colony formation, and transwell assays. Luciferase assay and RNA pulldown assays were conducted to illustrate the underlying molecular mechanism. Results: DDX11-AS1 expression was upregulated in glioma tissues and cells. DDX11-AS1 overexpression was linked with poor prognostic value. DDX11-AS1 knockdown suppressed proliferation, migration, and invasion while inducing apoptosis. DDX11-AS1 interacted with miR-499b-5p to eliminate it, leading to upregulation of RWDD4 expression. RWDD4 was upregulated in glioma while miR-499b-5p was downregulated. Conclusion: DDX11-AS1 upregulation promotes glioma progression through acting as a competing endogenous RNA for miR-499b-5p to upregulate RWDD4.

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“…Numerous studies have reported that lncRNAs participate in the regulation of tumor progression ( 18 – 20 ). In the present study, it was demonstrated that SNHG6 promoted melanoma cell viability, migration and invasion by upregulating RAP2B expression via sponging miR-101-3p.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA SNHG6 promotes tumorigenesis in melanoma cells via the microRNA‑101‑3p/RAP2B axis

Zhou

Wang

et al. 2020

Oncol Lett

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Numerous studies have reported that the long non-coding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6; ENSG00000245910) participates in the development of malignant tumors. However, the underlying mechanism of SNHG6 in the development of melanoma remains unknown. Thus, the present study aimed to investigate the biological role of SNHG6 in the progression of melanoma. SNHG6 expression in melanoma tissues and cells was assessed using a bioinformatics approach and reverse transcription-quantitative PCR analysis. Cell viability was determined using the Cell Counting Kit-8 and colony formation assays. The correlation between microRNA (miR)-101-3p, SNHG6 and RAP2B expression levels was assessed using Pearson's correlation analysis. Bioinformatic analysis and luciferase reporter assay were utilized to confirm the interaction between miR-101-3p and SNHG6 or RAP2B. The Transwell assay was conducted to examine the migratory and invasive activities of melanoma cells. In the present study, SNHG6 expression was upregulated in melanoma tissues and cell lines, and SNHG6 silencing suppressed melanoma cell viability, migration and invasion. SNHG6 was directly bound to miR-101-3p, which interacted with RAP2B. In addition, miR-101-3p expression was negatively correlated with SNHG6 or RAP2B expression. miR-101-3p silencing partially abrogated the suppressive effect of SNHG6-knockdown on RAP2B expression. Moreover, the data demonstrated that RAP2B overexpression reversed the inhibitory effects on melanoma cell proliferation, migration and invasion induced by SNHG6 silencing. In conclusion, the present study identified that SNHG6 accelerated melanoma progression via regulating the miR-101-3p/RAP2B axis. Thus, the SNHG6/miR-101-3p/RAP2B signaling pathway may be a novel therapeutic target for melanoma.

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<p>lncRNA MT1JP Suppresses Biological Activities of Breast Cancer Cells in vitro and in vivo by Regulating the miRNA-214/RUNX3 Axis</p>

Cited by 10 publications

References 37 publications

Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

LncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis

Long non‑coding RNA SNHG6 promotes tumorigenesis in melanoma cells via the microRNA‑101‑3p/RAP2B axis

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