<p>LncRNA LUADT1 Promotes Oral Squamous Cell Carcinoma Cell Proliferation by Regulating miR-34a/GAS1 Axis</p>

Abstract

Introduction: The oncogenic role of lncRNA LUADT1 has been investigated only in lung cancer. This study aimed to investigate the role of LUADT1 in oral squamous cell carcinoma (OSCC). Patients and Methods: The expression levels of LUADT1 in paired OSCC and non-tumor tissues from OSCC patients were determined by RT-qPCR. A 5-year follow-up study was performed to analyze the prognostic value of LUADT1 for OSCC. Dual-luciferase assay and overexpression experiments were performed to assess the interactions among LUADT1, miR-34a and GASL1. Cell proliferation was analyzed by cell proliferation assay. Results: In this study, we found that LUADT1 was upregulated in OSCC and predicted poor survival. LUADT1 was predicted to interact with miR-34a, which was confirmed by dualluciferase activity assay. However, overexpression experiments showed that they did not affect the expression of each other. Interestingly, overexpression of LUADT1 resulted in upregulation of GAS1, a target of miR-34a. Cell proliferation assay revealed that overexpression of LUADT1 and GAS1 resulted in promoted cell proliferation. MiR-34a played an opposite role and reversed the effects of LUADT1 overexpression. Conclusion: LUADT1 may promote OSCC proliferation by regulating miR-34a/GAS1 axis.

LncRNA LHFPL3-AS1 Promotes Oral Squamous Cell Carcinoma Growth and Cisplatin Resistance Through Targeting miR-362-5p/CHSY1 Pathway

“…LncRNA has been reported to play essential roles in cancer and regulate OSCC development. 17 For example, lncRNA RBM5-AS1 contributes to proliferation, migration and invasion of OSCC through regulating miR-1285-3p/YAP1 cascade. 18 LINC01234 promotes tumor growth and invasion in OSCC by targeting miR-647/NUPR1 axis.…”

The role of lncRNAs and XIST in oral cancer

“…However, this treatment regimen has not helped in significantly improving the five-year survival rate ( Alkhadar et al, 2021 ). There is mounting evidence that has demonstrated that lncRNAs play a crucial role related to the survival rate in oral cancer ( Zhang et al, 2018a ; Momen-Heravi and Bala, 2018 ; Gao et al, 2020 ; Chen et al, 2021 ). Moreover, the expression pattern of lncRNAs plays a role in the diagnosis and therapy of oral cancer ( Momen-Heravi and Bala, 2018 ).…”

A positive feedback loop between TAZ and miR-942-3p modulates proliferation, angiogenesis, epithelial-mesenchymal transition process, glycometabolism and ROS homeostasis in human bladder cancer

“…GAS1 is a well-known cell growth suppressor [ 37 ] and is involved in tumorigenesis and progression [ 38 – 40 ]. Aberrant expression of GAS1 reduces tumorigenicity in human brain tumor-initiating cells [ 41 ], while downregulation of GAS1 expression is a potential biomarker of clear cell renal cell carcinoma [ 42 ].…”