The role of lncRNAs and XIST in oral cancer

Liu, Huimin; Wang, Dongxu; Kan, Shaoning; Hao, Ming; Chang, Lu; Lu, Pengxu; Liu, Yangyang; Jin, Ye; Liu, Weiwei

doi:10.3389/fcell.2022.826650

Cited by 6 publications

(4 citation statements)

References 85 publications

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“…LncRNAs are RNA molecules longer than 200 nucleotides that do not carry protein coding capacity [ 49 ]. Several lncRNAs have been shown to be crucial players in different cancers [ 50 , 51 , 52 , 53 ] and many of them are considered as new biomarkers [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Jacksi

Schád

Buday

et al. 2023

IJMS

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Tks4 is a large scaffold protein in the EGFR signal transduction pathway that is involved in several cellular processes, such as cellular motility, reactive oxygen species-dependent processes, and embryonic development. It is also implicated in a rare developmental disorder, Frank–ter Haar syndrome. Loss of Tks4 resulted in the induction of an EMT-like process, with increased motility and overexpression of EMT markers in colorectal carcinoma cells. In this work, we explored the broader effects of deletion of Tks4 on the gene expression pattern of HCT116 colorectal carcinoma cells by transcriptome sequencing of wild-type and Tks4 knockout (KO) cells. We identified several protein coding genes with altered mRNA levels in the Tks4 KO cell line, as well as a set of long non-coding RNAs, and confirmed these changes with quantitative PCR on a selected set of genes. Our results show a significant perturbation of gene expression upon the deletion of Tks4, suggesting the involvement of different signal transduction pathways over the well-known EGFR signaling.

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Section: Resultsmentioning

confidence: 99%

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Jacksi

Schád

Buday

et al. 2023

IJMS

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“…In summary, XIST plays a regulatory role in developing PTC through the miR-101-3p/CLDN1 axis. XIST is also proved to be involved in the progression of other malignant tumors through complex pathways [ [59] , [60] , [61] ].…”

Section: Lncrnas-mirnas-protein Signaling Axesmentioning

confidence: 99%

Novel role of lncRNAs regulatory network in papillary thyroid cancer

Su,

Mei,

Jiang

et al. 2024

Biochemistry and Biophysics Reports

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“…H19 was found to enhance vascular pro-inflammatory IL-6 and MCP-1 and promote AAA formation by enhancing macrophage infiltration ( 65 ). X-inactive specific transcript (XIST) is an lncRNA located on the X chromosome, and its role in certain cancers has been elucidated, including breast cancer, rectal cancer, oral cancer ( 66 – 68 ). XIST regulates apoptosis and proliferation through competitive miRNA mechanisms, closely related to the development and growth of tumors ( 69 , 70 ).…”

Section: Epigenetic Mechanism Of Abdominal Aortic Aneurysmmentioning

confidence: 99%

Epigenetic modifications in abdominal aortic aneurysms: from basic to clinical

Liu,

Sun,

Gou

et al. 2024

Front. Cardiovasc. Med.

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Abdominal Aortic Aneurysm (AAA) is a disease characterized by localized dilation of the abdominal aorta, involving multiple factors in its occurrence and development, ultimately leading to vessel rupture and severe bleeding. AAA has a high mortality rate, and there is a lack of targeted therapeutic drugs. Epigenetic regulation plays a crucial role in AAA, and the treatment of AAA in the epigenetic field may involve a series of related genes and pathways. Abnormal expression of these genes may be a key factor in the occurrence of the disease and could potentially serve as promising therapeutic targets. Understanding the epigenetic regulation of AAA is of significant importance in revealing the mechanisms underlying the disease and identifying new therapeutic targets. This knowledge can contribute to offering AAA patients better clinical treatment options beyond surgery. This review systematically explores various aspects of epigenetic regulation in AAA, including DNA methylation, histone modification, non-coding RNA, and RNA modification. The analysis of the roles of these regulatory mechanisms, along with the identification of relevant genes and pathways associated with AAA, is discussed comprehensively. Additionally, a comprehensive discussion is provided on existing treatment strategies and prospects for epigenetics-based treatments, offering insights for future clinical interventions.

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The role of lncRNAs and XIST in oral cancer

Cited by 6 publications

References 85 publications

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Novel role of lncRNAs regulatory network in papillary thyroid cancer

Epigenetic modifications in abdominal aortic aneurysms: from basic to clinical

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