&lt;p&gt;LncRNA DLX6-AS1 Promotes the Progression of Neuroblastoma by Activating STAT2 via Targeting miR-506-3p&lt;/p&gt;

Hu, Yanping; Sun, Huifang; Hu, Jiting; Zhang, Xiaomin

doi:10.2147/cmar.s252521

Cited by 21 publications

(15 citation statements)

References 40 publications

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“…Therefore, the miRNA network is very complicated. Many studies have shown that miR-506-3p acts as a tumor suppressor gene in cancers, including osteosarcoma [ 42 ], glioma [ 43 ], nasopharyngeal carcinoma [ 44 ] and so on. In our work, we found that overexpressing miR-506-3p can inhibit the proliferation, migration and invasion of CRC cells and promote apoptosis.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2

et al. 2021

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A large number of studies have shown that microRNA (miRNA) has an important relationship with the occurrence and development of colorectal cancer (CRC), but its specific molecular mechanism has not been fully elucidated. This study is to explore the influence of miR-506-3p on the malignant behavior of CRC and its underlying molecular mechanism. Our results show that miR-506-3p was lowly expressed and enhancer of zeste homologue 2 (EZH2) was highly expressed in CRC. Overexpressing miR-506-3p or silencing EZH2 inhibited CRC cell proliferation, migration and invasion and promoted apoptosis. Inhibiting miR-506-3p promoted CRC cell proliferation, migration and invasion but inhibited apoptosis. These impacts were reversed after co-transfecting si-EZH2. Further mechanism studies have shown that miR-506-3p can reduce EZH2 expression in CRC cells by binding to the 3ʹUTR end of EZH2. In summary, the results of this study show that miR-506-3p inhibited CRC progression through targeting EZH2 expression. This provides a new molecular target for the clinical treatment of CRC in the future.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2

et al. 2021

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“…Glycolysis can provide the energy for tumor cell growth and the promotion of glycolytic metabolism indicates the malignant progression of types of cancer (7). a number of lncrnas have been shown to regulate the metabolic process of glycolysis in types of cancer, including oc (8)(9)(10). it may be pertinent to seek the useful targets in oc progression through the glycolytic metabolism.…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis

Liu

Wang

et al. 2021

Mol Med Rep

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long non-coding rna (lncrna) o-phthalaldehydeinteracting protein 5 antisense transcript 1 (oiP5-aS1) serves major roles in the progression of various types of cancer. The present study investigated its biological function in ovarian cancer (oc) and its mechanisms. The levels of oiP5-aS1, microrna-128-3p (mir-128-3p) and cyclin G1 (ccnG1) were examined by reverse transcription-quantitative Pcr. cell viability, apoptosis, migration and invasion were detected to analyze cellular progression. Glycolytic metabolism was assessed by detecting the levels of glucose consumption and lactate production. ccnG1 and hexokinase 2 protein levels were measured by western blotting. dual-luciferase reporter assay, rna immunoprecipitation and rna pull-down assays were performed to affirm the interaction between two molecules. oiP5-aS1 was found to be upregulated in oc tissues and cells. Knockdown of oiP5-aS1 suppressed cell viability, migration, invasion and glycolysis while promoting apoptosis in oc cells. oiP5-aS1 interacted with mir-128-3p and functioned as an oncogene by sequestering mir-128-3p. in addition, ccnG1 was a target gene for mir-128-3p and mir-128-3p regulated the ccnG1-induced effects on oc cells by downregulating ccnG1. oiP5-aS1 upregulated the expression of ccnG1 via targeting mir-128-3p. oiP5-aS1 knockdown also inhibited tumor growth of oc in vivo by modulating the expression of mir-128-3p and ccnG1. collectively, these data illustrated that the oncogenic role of oiP5-aS1 in oc was associated with the mir-128-3p/ccnG1 axis at least in part. oiP5-aS1 might be a probable diagnostic and therapeutic biomarker for the treatment of oc patients.

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“…Moreover, one research on DLX6‐AS1 indicated that depletion of DLX6‐AS1 inhibited neuroblastoma cell glycolysis in vitro. 265 CircCUX1 also contributed to aerobic glycolysis and neuroblastoma progression. 266 High expression of circCUX1 represented a lower survival probability.…”

Section: Lncrnas and Circrnas In Neuroblastomamentioning

confidence: 99%

LncRNAs and CircRNAs in cancer

Yin

Lin

et al. 2022

MedComm

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It is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application potential in cancer therapy cannot be ignored. For example, lncRNAs can be involved in tumor‐related signal transduction pathways, cell cycle control, DNA damage, epigenetic regulation, and microRNA control. A group of studies confirmed that abnormal expression of lncRNAs can affect cancer progression. Furthermore, as covalently closed continuous circular ncRNAs, many recent studies have shown that circRNAs have regulatory effects and other important biological significances in cancer. Interestingly, circRNAs were found to have translational functions. This has greatly attracted people's attention to circRNAs research. In this review, we introduce the important roles of lncRNAs and circRNAs in some representative cancers, respectively. Furthermore, we focus on the biological functions and important clinical therapeutic implications of lnRNAs and circRNAs in neuroblastoma. Our review also focuses on providing rationale and relevant references for novel biomarkers for neuroblastoma diagnosis, prognosis, and treatment.

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<p>LncRNA DLX6-AS1 Promotes the Progression of Neuroblastoma by Activating STAT2 via Targeting miR-506-3p</p>

Cited by 21 publications

References 40 publications

MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2

MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2

Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis

LncRNAs and CircRNAs in cancer

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