&lt;p&gt;Is Agomelatine Associated with Less Sedative-Hypnotic Usage in Patients with Major Depressive Disorder? A Nationwide, Population-Based Study&lt;/p&gt;

Hsing, Shih-Chun; Jin, Yo-Ting; Tzeng, Nian‐Sheng; Chung, Chi‐Hsiang; Chen, Tien‐Yu; Chang, Hsin‐An; Kao, Yu Hsun; Chien, Wu-Chien

doi:10.2147/ndt.s257723

Cited by 4 publications

(4 citation statements)

References 64 publications

(76 reference statements)

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“…Due to opaque information and excessive negative public opinion, employees have a negative attitude towards personal employment prospects, business management level, and macroeconomic situation [ 9 ]. The perceived strength of novel coronavirus pneumonia event has a profound impact on the physical and mental health of employees [ 10 ]. According to the event system theory, the event strength includes novelty, disruption, criticality, and strength stimuli of different latitudes affect the individual’s mental state.…”

Section: Theoretical Basis and Research Hypothesesmentioning

confidence: 99%

The Influence of the COVID-19 Event on Deviant Workplace Behavior Taking Tianjin, Beijing and Hebei as an Example

Liu

Zhang

Zhao

2020

IJERPH

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Background: Since the beginning of 2020, the Corona Virus Disease has broken out globally. This public health incident has had a great impact on the work and life of the public. Aim: Based on the event system theory, this article explored the influence of the “COVID-19” event on emotional exhaustion and deviant workplace behaviors. Methods: This survey’s objects are employees working in Tianjin, Beijing, Hebei affected by the epidemic. Using the questionnaire star, the online platform of the Marketing Research Office of Peking University and “snowball” methods 700 questionnaires were collected. Results: The response rate was 89.71% (n = 700). Female employees are more sensitive to the perceived event strength of the novel coronavirus pneumonia than male employees (F = 10.94, p <0.001); Employees aged 30–40 affected by the epidemic have the highest level of emotional exhaustion (F = 5.22, p < 0.01); A higher education level leads to a higher level of emotional exhaustion (F = 4.74, p < 0.01); The emotional exhaustion is polarized with the annual family income (F = 4.099, p < 0.01). Conclusions: The novelty, disruption, criticality of the Corona Virus Disease event has had a positive impact on the emotional exhaustion of employees in the workplace; Emotional exhaustion plays a partly mediating role between event strength with constructive deviant behaviors, and destructive deviant behaviors. Emotional exhaustion has a positive effect on creative constructive deviant behaviors, challenging constructive deviant behaviors, and interpersonal destructive deviant behaviors. Emotional exhaustion has a negative impact on organizational destructive deviant behaviors, and has no significant impact on interpersonal constructive deviant behaviors.

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Section: Theoretical Basis and Research Hypothesesmentioning

confidence: 99%

The Influence of the COVID-19 Event on Deviant Workplace Behavior Taking Tianjin, Beijing and Hebei as an Example

Liu

Zhang

Zhao

2020

IJERPH

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“…Therefore, the LHID for the study period 2000–2011 does not include information regarding agomelatine usage. While reboxetine was banned in 2006, bupropion and duloxetine were licensed within the study period but had relatively low prevalence, ranging from 0.2% to 0.7% [ 29 , 30 ]. Therefore, antidepressant prescriptions associated with agomelatine, bupropion, reboxetine, and duloxetine were not included.…”

Section: Methodsmentioning

confidence: 99%

An Exploratory Study of the Association between Housing Price Trends and Antidepressant Use in Taiwan: A 10-Year Population-Based Study

Lee

Chen

Lin

2021

IJERPH

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This study examined the relationship between various economic indexes and incidences of antidepressant prescriptions during 2001–2011 using the National Health Insurance Research Database (NHIRD). As of 2007, approximately 98.4% of Taiwanese people were enrolled in the NHIRD. In total, 531,281 records identified as antidepressant prescriptions were collected. Furthermore, 2556 quarterly observations from the Taiwan Housing Index (THI) and Executive Yuan were retrieved. We examined the association between the housing index and antidepressant prescription incidence. During the 10-year follow-up period, a higher incidence of antidepressant prescriptions was associated with the local maximum housing index. The relative risk of being prescribed antidepressant increased by 13.3% (95% confidence interval (CI): 1.01~1.27) when the THI reached a peak. For the low-income subgroup, the relative risk of being prescribed antidepressants increased by 28% during the high season of the THI. We also stratified the study sample on the basis of their sex, age, and urbanization levels. Both sexes followed similar patterns. During 2001–2011, although rising economic indexes may have increased incomes and stimulated the housing market, the compromise of public mental health could be a cost people have to pay additional attention to.

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“…Agomelatine, which is a potent agonist of 𝑀𝑇 1 and 𝑀𝑇 2 melatonin receptors, as well as 5-𝐻𝑇 2 C receptor antagonist, seems to maintain and improve sleep and mood simultaneously and helps to maintain alertness throughout the daytime, without causing daytime sedation. Also, its half-life is longer in comparison with melatonin (2.3 hours vs. 30-45 minutes, (8,10)). Because of melatonin's short half-life (<30 min), its effectiveness in enhancing and maintaining sleep has not been identified in different studies.…”

Section: Glossary Ahimentioning

confidence: 99%

Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.

et al. 2023

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Purpose: Obstructive sleep apnea (OSA) is a common serious sleep disorder. Melatonin-based drugs such as agomelatine may have beneficial effects on patients with sleep disorders. This study aimed to evaluate agomelatine effects on polysomnography parameters in patients with OSA. Methods: In this randomized, parallel, and single-blind study, seventy patients 18 years of age or older with obstructive sleep apnea who were referred to the sleep clinic were evaluated. The patients were randomly assigned into agomelatine and control groups. Patients in the agomelatine group received 50 mg agomelatine, one hour before sleep, for three consecutive nights prior to the polysomnography test, while the patients in the control group did not receive agomelatine. Sleep test parameters were compared between the two groups. Results: Three parameters in the agomelatine versus control group showed significant differences. They were the median and interquartile range of the total sleep time, 397 [326.5-437.4] vs. 287.5 [184-393.1; p, 0.004] minuets, sleep efficiency percentage, 75.6 [71-87.4] vs. 65.1 [50.8-80.1; p, 0.005] and the wakening percentage, 7.5 [12.01-27.6] vs. 8.8[18.3-49; p, 0.004] agomelatine vs. control group. Other polysomnography parameters revealed no significant differences between the two groups. Conclusions: Agomelatine administration in patients with OSA may improve total sleep time, sleep efficiency percentage and the percentage of patients’ awakening.

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<p>Is Agomelatine Associated with Less Sedative-Hypnotic Usage in Patients with Major Depressive Disorder? A Nationwide, Population-Based Study</p>

Cited by 4 publications

References 64 publications

The Influence of the COVID-19 Event on Deviant Workplace Behavior Taking Tianjin, Beijing and Hebei as an Example

The Influence of the COVID-19 Event on Deviant Workplace Behavior Taking Tianjin, Beijing and Hebei as an Example

An Exploratory Study of the Association between Housing Price Trends and Antidepressant Use in Taiwan: A 10-Year Population-Based Study

Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.

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