<p>Impact of arterial hypertension and type 2 diabetes on cardiac autonomic modulation in obese individuals with recommendation for bariatric surgery</p>

Abstract

Background and aimObese individuals with recommendation for bariatric surgery (BS) exhibit increased cardiovascular risk. The association of obesity with comorbidities, such as arterial hypertension (HTN) and type 2 diabetes mellitus (T2DM) can worsen cardiovascular dysfunction. This study aimed to investigate the effect of HTN on cardiac autonomic function and whether diabetes exacerbates HTN-related impairment of autonomic function in obese subjects.MethodsSamples (n=63) were allocated to three groups: Obese without HTN and T2DM (n=29), Obese with HTN (OHTN, n=17) and OHTN with T2DM (OHTN+T2DM, n=17), in which anthropometric measures, body composition, blood biochemical parameters, blood pressure (BP) and heart rate variability (HRV) were evaluated.ResultsThe age was higher in OHTN+T2DM and OHTN than in obese groups (p<0.05). OHTN+T2DM individuals had increased neck circumference and compromised glycemic profile when compared to obese and OHTN groups (p<0.05). Mean values for standard deviation of RR (SDRR), square root of the mean squared differences of successive RR interval (RMSSD) and number of pairs of successive normal-to-normal beat intervals that differed by 50 ms (pRR50) were significantly lower in OHTN+T2DM and OHTN groups when compared to patients with obesity alone (p<0.05). The low frequency (LF), low frequency/high frequency (LF/HF) ratio were higher in the OHTN+T2DM and OHTN than subjects with obesity alone (p<0.05). Nonlinear parameters SD2 and SD1 were also lower in the OHTN+T2DM when compared to the obese group (p<0.05). However, the SD2/SD1 ratio was higher in the OHTN+T2DM and OHTN groups than the obese group. ConclusionT2DM and/or HTN impair the cardiac autonomic function in obese patients. However, the presence of T2DM did not exacerbate the hypertension-related impairment of autonomic function.

Association of worsening of nonalcoholic fatty liver disease with cardiometabolic function and intestinal bacterial overgrowth: A cross-sectional study

“…Glucose and Lipid dysmetabolism have been associated with impaired HRV and cardiac autonomic dysfunction in obese and NAFLD subjects [15,22]. However, in the present study, the glucose and lipid serum levels did not correlate expressively with worsening of HRV indices; AST serum levels, however, were negatively correlated with SDRR, RMSSD and SD1.…”

“…The heart rate (HR) and the following measures of HRV analysis were determined; 1) timedomain parameters: average R-R interval, standard deviation between the duration of RR intervals (SDRR), the square root of the mean of the sum of the squares of the successive differences between adjacent normal-to-normal beats (RMSSD), and the number of pairs of successive normal-to-normal beat intervals that differed by 50 ms (pRR50); 2) frequency-domain parameters: low frequency (LF) band (from 0.04 to 0.15 Hz) and high frequency (HF) band (from 0.15 to 0.40 Hz) and the LF/HF ratio, the power of each spectral component was calculated in normalized units (un); 3) Nonlinear parameters (SD1 and SD2). Poincaré scatters plots were constructed and investigated as a nonlinear tool, including the transverse axes (SD1, an indicator of parasympathetic activity) and the longitudinal axes (SD2 a function of sympathetic and vagal activity) [15].…”

Factors associated with musculoskeletal symptoms and heart rate variability among cleaners – cross-sectional study

“…In addition, HRV indices are reduced in both the supine and orthostatic standing positions. This shows the imbalance of the cardiac autonomic system that can be related to the development of cardiovascular diseases [19][20][21]. HRV indices were also inversely associated with age, indicating that HRV indices in the time and frequency domains decrease and the LF/HF ratio increases with the increase in age.…”

“…It is also used as an indicator of morbidity and mortality [19]. Autonomic imbalance, characterized by a hyperactive sympathetic system and a hypoactive parasympathetic system, is associated with various pathological conditions, including obesity, hypertension and diabetes [19][20][21]. Although cleaners have risk factors for cardiovascular disease, no studies were found investigating HRV in this population.…”

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

“…The prevalence of overweight and obesity has increased worldwide and is recognized as a chronic disease of complex management and increased risk of morbidity and mortality. 1,2 Early evidence has shown that serum levels of 25-hydroxyvitamin D [25(OH)D] are frequently reduced in obese subjects [3][4][5][6] and that adipose tissue serves as a reservoir for vitamin D, leading to less bioavailability and reduced serum levels. 6,7 An early study demonstrated that obese women have greater adipose stores of vitamin D in subcutaneous and omental comportments.…”