&lt;p&gt;Hyaluronic acid-modified mesoporous silica-coated superparamagnetic Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; nanoparticles for targeted drug delivery&lt;/p&gt;

Fang, Zhengzou; Li, Xinyuan; Xu, Zeyan; Du, F.; Wang, Wendi; Shi, Ruihua; Gao, Daqing

doi:10.2147/ijn.s213974

Cited by 68 publications

(23 citation statements)

References 45 publications

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“…[32][33][34] They were expected to accumulate in cancer tissues as a combined function of the magnetic targeting-enhanced EPR effect and HA-mediated active targeting after intravenous injection. 35 Particle sizes smaller than 200 nm are conducive to drug accumulation at the tumor site based on the EPR effect, thereby reducing the drug dose and minimizing toxicity. 36 The size of HA-I/D-LPNs was 182.3 ± 5.1 (Table 1), which was smaller than 200 nm and larger than that of I/D-LPNs and LPNs.…”

Section: Characterization Of Lpnsmentioning

confidence: 99%

<p>Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer</p>

Wang¹,

Zang²,

Wei³

et al. 2020

DDDT

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Background: The current approach for treating colorectal cancer favors the use of drug and gene combination therapy, and targeted nano-systems are gaining considerable attention for minimizing toxicity and improving the efficacy of anticancer treatment. The aim of this study was to develop ligand-modified, irinotecan and gene co-loaded lipid-polymer hybrid nanocarriers for targeted colorectal cancer combination therapy. Methods: Hyaluronic acid modified, irinotecan and gene co-loaded LPNs (HA-I/D-LPNs) were prepared using a solvent-evaporation method. Their average size, zeta potential, drug and gene loading capacity were characterized. The in vitro and in vivo gene transfection and anti-tumor ability of this nano-system were evaluated on colorectal cancer cells and mice bearing colorectal cancer model. Results: HA-I/D-LPNs had a size of 182.3 ± 5.1, over 80% drug encapsulation efficiency and over 90% of gene loading capacity. The peak plasma concentration (C max) and half-life (T 1/2) achieved from HA-I/D-LPNs were 41.31 ± 1.58 μg/mL and 12.56 ± 0.67 h. HA-I/ D-LPNs achieved the highest tumor growth inhibition efficacy and the most prominent transfection efficiency in vivo. Conclusion: HA-I/D-LPNs exhibited the most remarkable tumor inhibition efficacy and best gene transfection efficiency in the tumor, which could prove the effects of the drug and gene combination therapy.

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Section: Characterization Of Lpnsmentioning

confidence: 99%

<p>Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer</p>

Wang¹,

Zang²,

Wei³

et al. 2020

DDDT

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“…CD44 is a transmembrane glycoprotein receptor that is overexpressed in malignant cells and promotes metastatic behavior [ 162 ]. MSN formulations used HA for gatekeeping functions with great success in preclinical models [ 127 , 128 , 129 ]. Lysozomal pronases similarly destroyed gatekeeper networks comprising polyglutamic acid, to release chemotherapeutic payloads into breast cancer cell models [ 136 ].…”

Section: Molecular Encapsulation and Stimuli-specific Release Responsementioning

confidence: 99%

“…SPIONs are the primary component for magnetic targeting. While many approaches use such NPs alone or modified [ 180 ], MSNs can be used to encapsulate SPIONs or other iron-based NPs to take advantage of magnetic targeting [ 129 , 265 , 266 ]. Superparamagnetic iron oxide nanoparticles (SPIONs) are also incorporated into MSNs as a means of inducing intracellular hyperthermia, while enhancing the effect of chemotherapies [ 267 ].…”

Section: Targeting Of Msns and Barriers To In Vivo Efficacymentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

et al. 2021

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Due to the theragnostic potential of mesoporous silica nanoparticles (MSNs), these were extensively investigated as a novel approach to improve clinical outcomes. Boasting an impressive array of formulations and modifications, MSNs demonstrate significant in vivo efficacy when used to identify or treat myriad malignant diseases in preclinical models. As MSNs continue transitioning into clinical trials, a thorough understanding of the characteristics of effective MSNs is necessary. This review highlights recent discoveries and advances in MSN understanding and technology. Specific focus is given to cancer theragnostic approaches using MSNs. Characteristics of MSNs such as size, shape, and surface properties are discussed in relation to effective nanomedicine practice and projected clinical efficacy. Additionally, tumor-targeting options used with MSNs are presented with extensive discussion on active-targeting molecules. Methods for decreasing MSN toxicity, improving site-specific delivery, and controlling release of loaded molecules are further explained. Challenges facing the field and translation to clinical environments are presented alongside potential avenues for continuing investigations.

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“…Cubic MNPs have higher M s than spherical MNPs of the same volume. Zhen et al, 2011;Kolhatkar et al, 2013 Zn, zinc;Co, cobalt;Fe, iron;O, oxygen;Cu, copper. MNPs (Fang et al, 2019;Gawali et al, 2019;Kim et al, 2019), rather than reliance only on the influence of magnetic fields. The reason might be due to the excessive intensity (>1 T) of the magnetic fields needed to treat tumor cells (Zhang et al, 2016a;Gokduman and Gok, 2020), which will interfere with other normal physiological activities of the body.…”

Section: Remanent Magnetization M R Tmentioning

confidence: 99%

Magnetic Materials in Promoting Bone Regeneration

et al. 2019

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Strategies to promote bone regeneration have been always the focus of investigations since the skeleton plays important roles like mechanical support, organ protection, and mineral homeostasis maintenance in the normal physiological activities of the human body. Magnetic fields have shown to be highly influential in the regeneration process, arousing tremendous interest in utilizing magnetic materials to enhance osteogenesis. In this work, we attempt a more comprehensive and detailed review of magnetic materials in promoting bone regeneration by including not only the mechanisms of bone regeneration, the history and basic concepts of magnetism, but also the types of magnetic materials as well as their influence parameters, designs and fabrication techniques with a focus on their usage in the field of bone regeneration like 3D printed scaffolds and implants. In addition, we provide some possible ideas on the synergistic action between magnetic and other materials on bone tissue. Finally, we propose the development trend of magnetic materials in the field of bone regeneration in the future. There is a huge demand for a more effective and less traumatic way to accelerate bone regeneration of the patients with diseases like fractures, tumors and osteoporosis that cause severe pains, bone loss, limb deformations, and restrictions of mobility. Magnetic materials have substantial potential to be manufactured into novel clinical applications with the ability to increase the bone regeneration efficiency.

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<p>Hyaluronic acid-modified mesoporous silica-coated superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles for targeted drug delivery</p>

Cited by 68 publications

References 45 publications

<p>Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer</p>

<p>Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer</p>

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

Magnetic Materials in Promoting Bone Regeneration

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