<p>Human Amniotic Membrane Plug for Macular Holes Coexisting with Rhegmatogenous Retinal Detachment</p>

Abstract

Purpose: To evaluate the efficacy of human amniotic membrane in promoting closure of macular holes coexisting with rhegmatogenous retinal detachment. Methods: This is a retrospective case series of 14 eyes (14 patients) with macula off retinal detachment. These patients had a macular hole coexistent with peripheral retinal breaks. A human amniotic membrane plug was used to close the macular hole during vitrectomy without ILM peeling. Results: The mean preoperative BCVA (logMAR value) was 1.87 ± 0.31. At the 6-month follow-up visit, the mean LogMAR best-corrected visual acuity was 0.67 ± 0.17. At the 6-month follow-up, all patients showed complete retinal reattachment with macular hole closure. Conclusion: The use of human amniotic membrane is a valid option in surgery for macular holes coexisting with rhegmatogenous retinal detachment.

Epiretinal large disc of blue‐stained lyophilized amniotic membrane to treat complex macular holes: a 1‐year follow‐up

“…Unstained cAM inlays were subsequently used successfully in small series (Abouhussein et al. 2020; Yadav et al. 2020) but comparability is restricted by heterogeneous baseline characteristics and follow‐up.…”

“…They extended their indications to include MH-associated RRD (Caporossi et al 2019) and HM eyes (Caporossi et al 2020a;Caporossi et al 2020b) with encouraging anatomic and functional results. Unstained cAM inlays were subsequently used successfully in small series (Abouhussein et al 2020;Yadav et al 2020) but comparability is restricted by heterogeneous baseline characteristics and follow-up. At the same time, Florent et al 2020 reported the first case of an lAM inlay, with only a 1-month follow-up showing MH closure and BCVA improvement.…”

Letter to the Editor Regarding “Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach”

“…Different techniques using cryopreserved AM (cAM), a widely available tissue, have provided results either used first as a plug transplanted into the subretinal space [2][3][4][5][6] or placed secondly in an epiretinal position [7]. Rizzo et al [2][3][4] used cAM from a local eye bank (Lucca, Italy) and positioned the plug with ''chorion down'', facing the retinal pigment epithelium (RPE) (i.e., as an inlay [8]).…”

“…Rizzo et al [2][3][4] used cAM from a local eye bank (Lucca, Italy) and positioned the plug with ''chorion down'', facing the retinal pigment epithelium (RPE) (i.e., as an inlay [8]). Abouhussein et al [5] used homemade cAM and Huang et al [6] used cAM from AmnioGraft (Bio-Tissue, Miami, FL, USA) transplanted as inlay. This chorion-down orientation of the plug of cAM subretinally transplanted may ensure proper adhesion on the RPE, preventing secondary displacement.…”

“…(4) The overlay could prevent the parafoveal atrophy described after retraction of cAM or lAM used as inlays [17]. (5) Even considering the time taken to fully unfold the lAM for overlay, operating time can be shortened versus inlay, thus reducing light toxicity [18]. ( 6) If an adverse event occurs, the lAM can be removed, which is a key point for a new technique.…”