Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane

Caporossi, Tomaso; Governatori, Lorenzo; Gambini, Gloria; Baldascino, Antonio; Vico, Umberto De; Ripa, Matteo; Scampoli, Alessandra; Carlà, Matteo Mario; Rizzo, Clara; Kilian, Raphael; Rizzo, Stanislao

doi:10.1007/s10384-022-00953-w

Cited by 4 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The human amniotic membrane plug was first used to promote the closure of recurrent MH 17,22 and was later used for treating myopic MHs with RD. 14,15 It was also used for repairing RD with PRBs located above PCRA in PM. 16 We used the technique to treat myopic MHs with or without RD, and we found that transplanting the LhAM graft through the MH into the subretinal space might lead to enlargement of MH and damage to the photoreceptors and retinal pigment epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 In recent years, a variety of surgical techniques have been used to treat RD associated with MHs and/or posterior PRBs in highly myopic eyes, including PPV combined with an inverted or inserted internal limiting membrane (ILM) technique, [9][10][11] autologous neurosensory retinal transplantation, 12,13 and human amniotic membrane transplantation. [14][15][16] For eyes with RD related to MHs situated over MA or posterior PRBs situated over the areas with PCRA, although the autologous neurosensory retinal transplantation is effective, the procedure is complicated and traumatic. The inverted or inserted ILM technique has been shown to improve the closure of MHs or posterior PRBs; however, it is difficult to harvest the ILM flap and ILM plugs in the areas of chorioretinal atrophy.…”

mentioning

confidence: 99%

“…In recent years, a variety of surgical techniques have been used to treat RD associated with MHs and/or posterior PRBs in highly myopic eyes, including PPV combined with an inverted or inserted internal limiting membrane (ILM) technique, 9–11 autologous neurosensory retinal transplantation, 12,13 and human amniotic membrane transplantation. 14–16…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pretreated Lham Graft Covering for Retinal Detachment With Posterior Retinal Breaks Above Chorioretinal Atrophy in Pathologic Myopia

Lin,

Chen,

Tang

et al. 2024

Retina

View full text Add to dashboard Cite

Purpose To compare the surgical results of vitrectomy with untreated or pretreated lyophilized human amniotic membrane (LhAM) grafts covering in treating retinal detachment (RD) related to posterior retinal breaks above chorioretinal atrophy (CRA) in pathologic myopia (PM). Methods Nineteen patients with RD related to macular hole (MH) located above macular atrophy (MA) and/or posterior paravascular retinal breaks (PRBs) located above patchy CRA in PM were included. These eyes underwent vitrectomy with untreated LhAM covering (n = 10) or perfluorocarbon liquid (PFCL)-assisted pretreated LhAM covering (n = 9; grafts were pretreated in 0.125% indocyanine green and 50% hypertonic glucose solution for 15 to 20 minutes). The closure of the MH or PRBs, reattachment of the retina and best corrected visual acuity (BCVA) were measured postoperatively. Results Postoperatively, graft dislocation or shift was only found in 2 eyes (20%) in the untreated group. The closure rate of the MH or PRBs was 80% (8/10) and 100% (9/9) in the untreated group and pretreated group, respectively. The occurrence rate of excessive gliosis was 40% and 11% in the untreated group and the pretreated group, respectively. In both groups. BCVA was improved and the retinal reattachment rate was 100% at the final visit. Conclusions PFCL-assisted pretreated LhAM graft covering was effective in treating RD related to MH and/or PRBs situated above MA or patchy CRA in PM. This technique appeared to reduce graft dislocation or shift, promote the closures of MHs/PRBs, and reduce the occurrence of gliosis.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Pretreated Lham Graft Covering for Retinal Detachment With Posterior Retinal Breaks Above Chorioretinal Atrophy in Pathologic Myopia

Lin,

Chen,

Tang

et al. 2024

Retina

View full text Add to dashboard Cite

show abstract

Shortfalls of free autologous internal limiting membrane transplantation for highly myopic refractory macular holes in a long term follow-up

Carlà,

Mateo

2024

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Background The aim of this study is to evaluate long-term anatomical and functional outcomes of autologous internal limiting membrane (ILM) transplantation in refractory highly myopic macular holes (HMMHs). Methods Retrospective interventional analysis of 13 eyes with refractory HMMH undergoing autologous ILM transplantation with gas tamponade. Best-corrected visual acuity (BCVA, Snellen), optical coherence tomography and fundus photography were scheduled at baseline and every follow-up visit (1, 3, 6, 12, 18, 24 months and the most recent). Preoperatively, we collected minimum linear diameter (MLD) and basal diameter (BD). Post-operatively, rates of external limiting membrane (ELM)/ellipsoid zone (EZ) restoration, excessive gliosis and subfoveal retinal pigmented epithelium (RPE) atrophy were evaluated. Results Average AXL was 31.45 ± 2.07 mm and mean follow-up was 47.2 ± 31.4 months. Anatomical success was reached in 7/13 eyes (54%), while 2 cases showed persisting HMMH, 2 cases had early recurrence and 2 cases late recurrence. BCVA went from 0.19 ± 0.18 to 0.22 ± 0.20 at final follow-up (p = 0.64), improving in 5/13 eyes (38%). One eye showed continuous ELM and EZ lines, while another eye showed an irregular ELM but no EZ. Post-operatively, 5 eyes (71%) developed progressive atrophy of the subfoveal RPE, while excessive gliosis was reported in 3 eyes (43%). Furthermore, one patient developed post-operative chronic macular edema-like changes in the perifoveal area. Conclusion Autologous ILM transplantation showed controversial anatomical outcomes and and poor visual results in refractory HMMH. Moreover, progressive subfoveal patchy atrophy and excessive gliosis are possible post-operative complications.

show abstract

Outcomes of amniotic membrane transplant for refractory macular hole – an optical coherence tomography and autofluorescence long-term study

Proença,

Antunes,

Ferreira

et al. 2024

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane

Cited by 4 publications

References 43 publications

Pretreated Lham Graft Covering for Retinal Detachment With Posterior Retinal Breaks Above Chorioretinal Atrophy in Pathologic Myopia

Pretreated Lham Graft Covering for Retinal Detachment With Posterior Retinal Breaks Above Chorioretinal Atrophy in Pathologic Myopia

Shortfalls of free autologous internal limiting membrane transplantation for highly myopic refractory macular holes in a long term follow-up

Outcomes of amniotic membrane transplant for refractory macular hole – an optical coherence tomography and autofluorescence long-term study

Contact Info

Product

Resources

About