<p>Evaluation of the efficacy of a new hyaluronic acid gel on dynamic and static wrinkles in volunteers with moderate aging/photoaging</p>

Abstract

PurposeAim of the study was to determine both clinically and by noninvasive instrumental evaluations the efficacy, tolerability and the duration of the effects of a new hyaluronic acid (HA) gel in human volunteers with moderate aging/photoaging.Patients and methodsEighteen volunteers (35–55 years) were enrolled in this single-center study. The subjects underwent five visits. The first visit was at baseline to determine the adherence to the inclusion criteria, followed by the first injection of the HA-based study product, and the second visit was at 48 hours after the injection. Two months later, a second injection was given (Visit 3) followed by a subsequent visit (Visit 4) after 48 hours. The last visit (Visit 5) was performed 5 months after the first injection. Clinical and instrumental evaluations as well as self-assessment by the subjects were recorded at each visit.ResultsA significant improvement of wrinkles’ grade around the eyes, vertical lip lines and wrinkles’ severity of nasolabial folds was recorded after the first injection and the effect increased after the second injection. Aging/photoaging grade and surface microrelief improved 2 months after the first injection procedure. These clinical improvements were paralleled by amelioration of instrumental skin profilometry and optical colorimetry. The treatments were very well tolerated by the volunteers as determined by the self-grading score.ConclusionThe results confirm the good esthetic performance and the duration of the effect of the HA-based study product (Viscoderm® Hydrobooster) on dynamic facial wrinkles and/or static facial lines. These effects were particularly evident after the second injection and were accompanied by a good tolerability of the product.

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“…Patients mean age was 43,3±7,7 years (31-56). Time elapsed between subsequent administrations averaged 4.3±0.47 weeks (4)(5). We investigated the patients' lifestyle, asking questions about sun exposure habits, smoking, sports activities, any previous and current disease and pharmacological therapies: 5 out of 10 patients (50%) were smokers, with an average consumption of 10 cigarettes per day.…”

“…In patients with atrophic acne scars, therapy can lead to improved scar appearance, skin texture, and patient satisfaction. 4,5 To date there are no published data about the combination of PRP and HA applied topically on the face to correct the signs of ageing, neither papers where topical PRP is associated to microneedling to rejuvenate the facial skin. The only published data in which PRP is used topically to improve face appearance in healthy volunteers is from Yuksal et al, who obtained a significant improvement in the patients' auto-evaluation rate, but the medical assessment showed a significant difference only for firmness-sagging.…”

Skin Aging & Modern Age Anti-aging Strategies

“…Aging/photoaging grade and surface microrelief improved 2 months after the first injection procedure. The treatments were very well tolerated by the volunteers as determined by the self-grading score [121]. Lee et.al, 2019 reported that Cross-linked hyaluronic acid (CLHA) patches were not an irritant, whereas a clinical study showed that application of single CLHA patches significantly improved skin hydration at the periorbital region for 3 days and at the nasolabial fold for 6 days.…”

Skin Aging & Modern Age Anti-Aging Strategies

“…Aging/photoaging grade and surface microrelief improved 2 months after the irst injection procedure. The treatments were very well tolerated by the volunteers as determined by the self-grading score [209]. Lee et al, 2019 reported that Cross-linked hyaluronic acid (CLHA) patches were not an irritant, whereas a clinical study showed that application of single CLHA patches signi icantly improved skin hydration at the periorbital region for 3 days and at the nasolabial fold for 6 days.…”