<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Abstract

Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to resolve those problems with good performance for colorectal cancer. The highlight of our review aims to summarize and discuss the enteric-coated nanoparticle drug delivery system specific for colorectal cancer disease. The main and supporting literatures were collected from published research articles of journals indexed in Scopus and PubMed databases. In the oral route of administration, Eudragit pH-sensitive copolymer as a coating agent prevents the degradation of the nanoparticle system from the gastric fluid and releases drug to intestinal-colon track. Therefore, it provides a colon-specific targeting ability. Impressively, enteric-coated nanoparticles having a sustained release profile significantly increase the cytotoxic effect of chemotherapeutic drugs and achieve cell-specific target delivery. The enteric-coated nanoparticle drug delivery system represents an excellent modification to improve the effectiveness and performance of anticancer drugs for colorectal cancer disease in terms of the oral route of administration.

Solid Dispersions of Gefitinib Prepared by Spray Drying with Improved Mucoadhesive and Drug Dissolution Properties

“…These targeted dosage forms can provide high local drug concentration with minimal systemic side effects. Colon cancer is one of the most commonly diagnosed cancers that causes cancer-related death worldwide (8,9).…”

Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

“…However, a recent study [110] proposes the administration of 5-fluorouracil-loaded nanoparticles against colorectal cancer via intestinal mucosa. The concept of surface chemotherapy of colorectal cancer lesions via gastric administration is supported by independent studies stressing the possibility of mucosal treatment of this type of cancer through various categories of polymeric materials [111][112][113][114][115]. In contrast to systemic administration, such an approach would allow, using appropriate agents, a combined treatment to kill cancer cells and concomitantly inhibit participating bacterial biofilms at the local level.…”

Nano-enabled theranostics for cancer

“…Ligandappended nano-drug delivery systems are beneficial but their construction is labor-intensive and requires several targeting designs which have to include the physiological variables of disease status, blood flow, and tissue architecture. 44,45 Stimuli-responsive nanocarriers have demonstrated the ability to release the drugs in a controlled manner by using external stimuli such as heat, light, ultrasound, pH, and ionic strength which can increase the targeting ability of the nanocarrier along with an increased accumulation of drugs at the required site. 9,46,47 Polymers derived from both natural and synthetic origin such as poly(lactic acid) (PLA), poly(lactide-co-glycolide) (PLGA), polycaprolactone (PCL), chitosan, and collagen are extensively used for biomedical applications.…”