&lt;p&gt;Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats&lt;/p&gt;

Mizorogi, Takayuki; Kobayashi, Motoo; Ohara, K; Okada, Yuki; Yamamoto, Ichiro; Arai, Toshiro; Kawasumi, Koh

doi:10.2147/vmrr.s277208

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Furthermore, the mean age of cats in these two studies was 3.5 (3.8) years. Mizorogi et al 36 have reported a higher concentration of the inflammatory marker serum amyloid A in older cats, suggesting that, as in humans, background inflammation increases over time. It is possible, therefore, that demographic factors and disease status may affect the comparative efficacy of robenacoxib and meloxicam.…”

Section: Discussionmentioning

confidence: 97%

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Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain

et al. 2023

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BackgroundInjectable non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly prescribed to queens undergoing ovariohysterectomy (OVH), but the requirement for postoperative administration is unclear and practices vary. Existing studies assessing efficacy rely on pain scoring by experienced clinicians. However, following OVH, most cats are discharged within hours of recovery.MethodsCats undergoing OVH were randomly assigned to two treatment groups: MEL and ROB. Cats in the MEL group (n = 76) received meloxicam (0.2 mg/kg) and those in the ROB group (n = 65) received robenacoxib (2 mg/kg). Owners were contacted by a blinded assessor 3 days postoperatively and asked to identify physical or behavioural changes and to assign pain scores using a numerical rating scale.ResultsMore cats in the ROB group displayed abnormal behaviours than cats in the MEL group (p = 0.03). Most owners assigned a pain score of 0 (72%) (n = 101), but pain scores were significantly higher in the ROB group than in the MEL group (p = 0.005).LimitationMethods of owner assessment of pain in cats have not been validated.ConclusionsBoth meloxicam and robenacoxib are effective in controlling postoperative pain. Meloxicam may have improved efficacy in certain patient populations. Applying a blanket approach to prescribing NSAIDs to cats undergoing OVH postoperatively may not be necessary. This has safety, environmental and cost implications.

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Section: Discussionmentioning

confidence: 97%

“…Furthermore, the mean age of cats in these two studies was 3.5 (3.8) years. Mizorogi et al 36 . have reported a higher concentration of the inflammatory marker serum amyloid A in older cats, suggesting that, as in humans, background inflammation increases over time.…”

Section: Discussionmentioning

confidence: 98%

Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain

et al. 2023

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“…Treatments targeting senescent cells and the SASP have broad potential implications in the field of veterinary medicine as the hallmarks of aging ( 6 ) are highly conserved across species ( 227 , 228 ). These hallmarks include DNA damage ( 229 ), telomere shortening ( 230 , 231 ), aberrant proteostasis ( 232 ), epigenetic modifications ( 233 ), altered nutritional signaling ( 234 , 235 ), cell senescence ( 193 , 213 , 215 , 231 , 236 ), stem cell depletion ( 237 ), mitochondrial dysfunction ( 238 , 239 ), and abnormal inflammatory signaling ( 240 , 241 ). Treatment of age-related diseases in veterinary species may further serve to bolster preclinical evidence for use in humans.…”

Section: Discussionmentioning

confidence: 99%

The potential for senotherapy as a novel approach to extend life quality in veterinary medicine

Williams,

Chow,

Dow

et al. 2024

Front. Vet. Sci.

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Cellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans. Senescent cells secrete inflammatory cytokines, proteins, and matrix metalloproteinases, termed the senescence associated secretory phenotype (SASP), which accelerates the aging processes. In preclinical models, drug interventions termed “senotherapeutics” selectively clear senescent cells and represent a promising strategy to prevent or treat multiple age-related conditions in humans and veterinary species. In this review, we summarize the current available literature describing in vitro evidence for senotheraputic activity, preclinical models of disease, ongoing human clinical trials, and potential clinical applications in veterinary medicine. These promising data to date provide further justification for future studies identifying the most active senotherapeutic combinations, dosages, and routes of administration for use in veterinary medicine.

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“…The elevated incidence of obesity in domiciled cats (28) justifies the importance of studies on the effects of dietary macronutrient composition on energy metabolism, physical activity, WT and BC. Obesity compromises lifespan and quality of life (29,30) , may increase inflammation and reduce energy metabolism (31) . Obesity is associated with age, neutering, housing conditions, owner conscientiousness, feeding method and food energy density (20,22,28) .…”

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confidence: 99%

High starch intake favours body weight control in neutered and spayed cats living in homes fed ad libitum

Goloni,

Pacheco,

Luis

et al. 2024

Br J Nutr

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Different starch-to-protein ratios were compared among neutered and spayed domiciled cats. Male and female obese and non-obese cats were fed kibble diets ad libitum for four months high in starch (HS(38%CP): starch 32%, protein 38%; dry-matter basis) or high in protein (HP(55%CP): starch 19%, protein 55%) but similar in energy and fat in a crossover design. Physical activity was evaluated using an accelerometer, and body composition (BC), energy expenditure (EE), and water turnover (WT) using the doubly labelled water method. Results were compared in a 2 diet × 2 sex × 2 body condition factorial arrangement. Cats fed the HS(38%CP) diet maintained a constant bodyweight, but lean mass (LM) tended to be reduced in female obese but to be increased in male non-obese (P<0•08) and increased in female non-obese cats (P=0•01). The HP(55%CP) diet induced an increase in cat bodyweight and LM (P<0•05) without altering BC proportion. EE tended to be higher in males (351 (SE 8) kJ/kg0.67/day) than females (330 (SE 8) kJ/kg0.67/day; P=0•06), was unaffected by diet or BC, decreased as age increased (R 2 0.44; P<0•01), and increased as physical activity increased (R 2 0.58; P<0•01). WT was higher for the HP(55%CP) diet (P<0•01) and increased with EE (R 2 0.65; P<0•01). The HS(38%CP) diet favoured bodyweight control during four months of ad libitum feeding. Caution is necessary to balance protein in diets of female obese cats over five years, as they may have low energy and food intake, with LM loss.

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<p>Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats</p>

Cited by 3 publications

References 21 publications

Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain

Robenacoxib versus meloxicam following ovariohysterectomy in cats: A randomised, prospective clinical trial involving owner‐based assessment of pain

The potential for senotherapy as a novel approach to extend life quality in veterinary medicine

High starch intake favours body weight control in neutered and spayed cats living in homes fed ad libitum

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