The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Zoë J. Williams,
Lyndah Chow,
Steven Dow
et al.
Abstract:Cellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans. Senescent cells secrete inflammatory cytokines, proteins, and matrix metalloproteinases, termed the senescence associated secretory phenotype (SASP), which accelerates the aging processes. In preclinical models, drug interventions termed “senotherapeutics” selectively clear senes… Show more
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