<p>Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City</p>

Abstract

IntroductionThe study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay.MethodsChild neurodevelopment was assessed at both 6 months and 12 months of age using the Gesell Development Inventory (GDI).ResultsThis study results reveal that multivariate linear analysis, cord BaP-DNA adduct level was inversely associated with developmental quotient score in the adaptive domain [β = −0.08; 95% CI: (−0.16, −0.003); p = 0.04], gross motor domain [β = −0.10; 95% CI: (−0.20, −0.01); p = 0.02], fine motor domain [β = −0.15; 95% CI: (−0.25, −0.05); p = 0.01], language domain [β = −0.12; 95% CI: (−0.21, −0.03); p = 0.02], and personal–social domain [β = −0.13; 95% CI: (−0.22, −0.04); p<0.01]. Further, multivariate logistic regression analysis showed increased cord BaP-DNA adduct levels associated with increased odds of delayed in language domain.ConclusionIn conclusion, the study suggested that prenatal PAH exposure monitored by umbilical cord blood BaP-DNA adducts may adversely affect the neurodevelopment of the infants at 12 months of age.

Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children

“…The infants were selected from our prospective birth cohort established in 2014 [ 38 , 39 ]. Pregnant women at the obstetrics clinic of the hospitals in Qingdao were invited to sign the informed-consent form for participation in this prospective cohort study.…”

Impact of Polycyclic Aromatic Hydrocarbon Exposure on Cognitive Function and Neurodegeneration in Humans. A Systematic Review and Meta-Analysis

“…PAH effect on impaired motor development was inconclusive, as it was confirmed by 4 studies (Perera et al 2008;Tang et al 2008;) (OR= 0.95, 95%CI, 0.58 to 1.53; OR= 1.91, 95%CI, 1.22 to 2.97; OR= 1.63, 95%CI, 1.00 to 2.65; OR= 1.82, 95%CI, 3.21 to 1.03 respectively) whereas 3 others could not confirm it. No association was found between PAH exposure and developmental motor ability by Polanska et al (2013), fine and gross motor abilities by Zhang et al (2019) and psychomotor abilities by Perera et al (2006).…”

“…1 study involved a Taiyuan population (Niu et al 2009) in addition to 2 selecting different subgroups from the Taiyuan Mother and Child Cohort Study (Cao et al 2020;Nie et al 2019). 3 involved populations from Tongliang (Perera et al 2008;Tang et al 2008;, and the remaining 2 from Shanxi province (Du et al 2020) and Qingdao City (Zhang et al 2019).…”

“…Only one study reported effect of PAH and reduced adaptive development (OR= 1.77, 95%CI, 1.09 to 2.88) while 4/5 reported no association with adaptive domains (Zhang et al 2019;Perera et al 2008;Tang et al 2008;Cao et al 2020). Size effects reported by the studies mentioned are graphically represented in figure 7 and listed in table 1.…”

“…did however report an effect on impaired thought problems (OR= 1.95, 95%CI, 1.3 to 2.91) which was contradicted byPerera et al (2013). Only 1/7 studies reported an association between PAH and social problems(Perera et al 2013) (OR= 1.57, 95%CI, 1.00 to 2.48), the remaining 6 reported no effect(Pagliaccio et al 2020;Zhang et al 2019, Perera et al 2008Tang et al 2008;Cao et al 2020).Both Perera et al (2013) andPagliaccio et al (2020) found no effect on rule breaking behaviour or somatic complaints Perera et al (2018). reported no associations with attention deficit hyperactivity disorder (ADHD) index scores, or hyperactive compulsive behaviour nor didPerera et al (2006) with total behavioural problems.…”