&lt;p&gt;Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model&lt;/p&gt;

Fu, Zhao-Yin; Wu, Zhi-Jiang; Zheng, Jin; Li, Nuo; Lu, Junyu; Chen, Menghua

doi:10.2147/dddt.s211906

Cited by 18 publications

(7 citation statements)

References 67 publications

(75 reference statements)

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“…6−8 Antioxidants could ameliorate AKI through inhibition of oxidative stress. 9 Curcumin (Cur) is a natural diphenolic compound with specific antioxidant and antiinflammatory properties. Cur exerted a reno-protective effect in AKI via relieving intracellular superoxide generation, increased superoxide dismutase levels, inhibition of oxidative stress cellular apoptosis, and inducing autophagy.…”

Section: Introductionmentioning

confidence: 99%

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Dual-Responsive Curcumin-Loaded Nanoparticles for the Treatment of Cisplatin-Induced Acute Kidney Injury

et al. 2022

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Acute kidney injury (AKI) has been a global public health concern leading to high patient morbidity and mortality in the world. Nanotechnology-mediated antioxidative therapy has facilitated the treatment of AKI. Herein, a hierarchical curcumin-loaded nanodrug delivery system (NPS@Cur) was fabricated for antioxidant therapy to ameliorate AKI. The nanoplatform could respond to subacidic and reactive oxygen species (ROS) microenvironments. The subacidic microenvironment led to a smaller size (from 140.9 to 99.36 nm) and positive charge (from −4.9 to 12.6 mV), contributing to the high accumulation of nanoparticles. An excessive ROS microenvironment led to nanoparticle degradation and drug release. In vitro assays showed that NPS@Cur could scavenge excessive ROS and relieve oxidative stress in H2O2-induced HK-2 cells through reduced apoptosis, activated autophagy, and decreased endoplasmic reticulum stress. Results from cisplatin-induced AKI models revealed that NPS@Cur could effectively alleviate mitochondria injury and protect kidneys via antioxidative protection, activated autophagy, decreased endoplasmic reticulum stress, and reduced apoptosis. NPS@Cur showed excellent biocompatibility and low toxicity to primary tissues in mice. These results revealed that NPS@Cur may be a potential therapeutic strategy for efficiently treating cisplatin or other cause-induced AKI.

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Section: Introductionmentioning

confidence: 99%

“…Aberrant and excessive reactive oxygen species (ROS) in AKI lead to oxidative stress, inflammation, and vascular damage. − Antioxidants could ameliorate AKI through inhibition of oxidative stress . Curcumin (Cur) is a natural diphenolic compound with specific antioxidant and anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Dual-Responsive Curcumin-Loaded Nanoparticles for the Treatment of Cisplatin-Induced Acute Kidney Injury

et al. 2022

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“…Although appropriate ROS is essential for intracellular signaling and immune response against pathogens, the excessive ROS can not be entirely scavenged by cellular antioxidants, which would mediate the severe damage on cells by destroying organelle, cell membrane, and nuclei DNA (Nita and Grzybowski, 2016 ). To protect injured tissues and prevent further damage of organs during transplantation, the administration of antioxidant reagents for scavenging ROS has been widely applied, such as edaravone (Fu et al, 2020 ). However, the usage of edaravone is generally accompanied by a series of side effects ranging from bruising to skin inflammation or rash, leading to many concerns and demands of new types of antioxidant reagents.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury

Chen

2020

Front. Chem.

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Ischemia-reperfusion injury (IRI) is a severe condition for most organs, which could occur in various tissues including brain, heart, liver, and kidney, etc. As one of the major hazards, reactive oxygen species (ROS) is excessively generated after IRI, which causes severe damage inside tissues and further induces the following injury via inflammatory response. However, current medical strategies could not thoroughly diagnose and prevent this disease, eventually leading to severe sequelae by missing the best time point for therapy. In the past decade, various nanoparticles that could selectively respond to ROS have been developed and applied in IRI. These advanced nanomedicines have shown efficient performance in detecting and treating a series of IRI (e.g., acute kidney injury, acute liver injury, and ischemic stroke, etc.), which are well-summarized in the current review. In addition, the nano-platforms (e.g., anti-IL-6 antibody, rapamycin, and hydrogen sulfide delivering nanoparticles, etc.) for preventing IRI during organ transplantation have also been included. Moreover, the development and challenges of ROS-responsive nanomedicine are systematically discussed for guiding the future direction.

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“…Specifically, the use of vanillin has been proposed to reduce kidney damage and cisplatin-induced nephrotoxicity [30]. Similarly, the use of EDA is also envisioned to prevent cisplatin-induced acute kidney injury [31] and as a reno-protective drug in diverse pathological situations [32][33][34]. Both EDA and vanillin can be useful protecting agents to reduce and prevent kidney diseases, but our work strongly suggests that the two compounds shall never be combined and used simultaneously, due to the high risk of adducts formation.…”

Section: Discussionmentioning

confidence: 99%

Mono‐ and bis‐edaravone adducts formed in the presence of vanillin in an aqueous solution

Regnault

Kouach

Goossens

et al. 2022

Separation Science Plus

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Edaravone is an antioxidant drug used for the treatment of amyotrophic lateral sclerosis. Edaravone has been shown to react with aldehydes, such as 6formylpterin. We investigated the reaction of edaravone with vanillin (used as a model aromatic aldehyde) to evidence the reaction products formed in an aqueous solution. Mono-and bis-adducts vanillin-(edaravone) 1-2 were characterized by high-performance liquid chromatography coupled to high-resolution mass spectrometry. Kinetic analysis revealed that the bis-adduct vanillin-(edaravone) 2 formed more intensely and more rapidly than the mono-adduct vanillin-(edaravone) 1 . Decay rates of 2.4 and 3.4 μM/min were calculated for vanillin and edaravone, respectively. The Michael addition of a second edaravone molecule onto the vanillin-(edaravone) 1 hybrid corresponds to a facile reaction compared to the initial Knoevenagel-type condensation between edaravone and vanillin. However, the bis-adduct vanillin-(edaravone) 2 can decompose in solution to provide the mono-adduct and regenerate small amounts of edaravone and vanillin. The regeneration of vanillin from vanillin-(edaravone) 2 was kinetically characterized. We compared the condensation of edaravone with fifteen aromatic aldehydes, to show that only vanillin and 3-methoxy-benzaldehyde can react easily with edaravone, the other aromatic aldehydes being less or not reactive. The study opens perspectives to apprehend the reactivity of edaravone with biologically relevant aldehydes.

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<p>Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model</p>

Cited by 18 publications

References 67 publications

Dual-Responsive Curcumin-Loaded Nanoparticles for the Treatment of Cisplatin-Induced Acute Kidney Injury

Dual-Responsive Curcumin-Loaded Nanoparticles for the Treatment of Cisplatin-Induced Acute Kidney Injury

Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury

Mono‐ and bis‐edaravone adducts formed in the presence of vanillin in an aqueous solution

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