<p>Difference in the impact of central sensitization on pain-related symptoms between patients with chronic low back pain and knee osteoarthritis</p>

Abstract

Purpose: The aims of the present study were to investigate whether the association between the Central Sensitization Inventory (CSI) score, pain-related symptoms, pain-related disability, and health-related quality of life differed by disease (chronic low back pain [CLBP] vs knee osteoarthritis [KOA]), and to determine optimal cutoff scores for the CSI reflecting disease-specific characteristics. Patients and methods: A total of 104 patients with CLBP and 50 patients with KOA were recruited. Central sensitization-related symptoms (CSI), EuroQol 5-dimension (EQ-5D), Brief Pain Inventory, widespread pain (Widespread Pain Index [WPI]), pressure pain threshold (PPT), and temporal summation (TS) were assessed and compared between the CLBP and KOA groups. Univariate correlation analysis was performed in each group. The receiver operating characteristic (ROC) curve analysis was performed to identify 1) presence/absence of central sensitization (CS), 2) presence/absence of central sensitivity syndromes (CSSs), and 3) pain intensity and pain interference in each group. Results: The CSI and WPI scores were significantly higher in the CLBP group than in the KOA group. EQ-5D and pain interference scores significantly correlated with the CSI score in both the CLBP and KOA groups. The WPI score, PPT, and TS did not correlate with the CSI score in either the CLBP or KOA group. The suggested cutoff scores were 28 in the CLBP group and 17 in the KOA group to identify presence or absence of CSSs, and 34 in the CLBP group and 18–19 in the KOA group to identify pain severity. Conclusion: The impact of CS on pain could differ between CLBP and KOA and that cutoff scores differ by each parameter we attempted to identify. Therefore, we should use the appropriate cutoff scores for the purposes and consider the difference in the impact of CS on pain by the patient group.

Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village

“…Our study showed that the intensity of LBP, as assessed by NRS, was significantly, but weakly, correlated with CSI. A weak correlation with intensity of pain itself had also been reported by previous studies in patients with musculoskeletal diseases; 6,20 this suggests that CS would be associated not only with pain itself but with multiple factors. On the other hand, our study showed that CSI was significantly correlated with health-related QOL scores, including EQ-5D and ODI.…”

“…These CSI scores were similar to those in our study. Mibu et al 20 also reported that the CSI score was significantly higher in cLBP patients than in knee OA patients of an orthopedic clinic. More recently, Roldán-Jiménez et al 39 evaluated CS symptoms of 395 chronic musculoskeletal disorders (CMPDs) patients, and reported that 37.8% of LBP patients had clinically relevant CSI scores (<40), whereas this was found in 8.1% of knee pain patients and 2.1% of shoulder pain patients.…”

“…Recent clinical studies have shown that CSI scores were significantly correlated with the intensity of LBP for patients with lumbar spine disorders who need surgical or non-surgical orthopedic treatments. 6 , 20 However, little is known about the CS and/or CSI of a local elderly population whose residents are predominantly of an age to be affected with lumbar spine disorders. Therefore, we decided to investigate the CS by CSI score of a population-based cohort study in a Japanese mountain village where the ageing rate is high and progressing, and the population turnover is low.…”

<p>Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life</p>

“…[14][15][16][17] Pain and its peripheral and central sensitization mechanisms concern with these psychological and functional complaints in both diseases. 18,19 On the other hand, the comorbidity of FM and knee OA was not well studied and reported. This combination may affect the OA therapy as well as FM and their outcomes.…”

The Association Between Alcohol Consumption and Pain Interference in a Nationally Representative Sample: The Moderating Roles of Gender and Alcohol Use Disorder Symptomatology

“…Pain interference is also closely related to central pain sensitization. Assessed by the Brief Pain Inventory (Cleeland and Ryan, ), pain interference was found to correlate with central sensitization on pain‐related symptoms assessed by the Central Sensitization Inventory (Mayer et al, ; Mibu et al, ). Finally, NESARC’s assessment of our constructs of interest across 2 longitudinal waves provides temporal precedence for hypothesis testing, although we emphasize that this study did not aim to draw causal inferences.…”