<p>Comparative diagnostic accuracy of ACE-III and MoCA for detecting mild cognitive impairment</p>

Abstract

ObjectiveThe aim of this study was to validate the reliability of the Chinese version of Addenbrooke’s Cognitive Examination III (ACE-III) for detecting mild cognitive impairment. Furthermore, the present study compares the diagnostic accuracy of ACE-III with that of Montreal Cognitive Assessment (MoCA).MethodsOne hundred and twenty patients with MCI and 136 healthy controls were included in the study. All patients were evaluated by the Chinese version of ACE-III, MoCA and MMSE.ResultsSubjects in the control group showed better performance in ACE-III total score and its subdomain scores than those in the MCI group. There was a significantly positive correlation between ACE-III total score and MoCA score. Meanwhile, there was also a significantly positive correlation between ACE-III total score and MMSE score. For ACE-III total score, a cut-off point of 85 yielded a sensitivity of 97.3% and a specificity of 90.7%. The AUC for ACE-III total score was 0.978. For MoCA, a cut-off point of 23 yielded a sensitivity of 86.5% and a specificity of 97.7%. The AUC for MoCA was 0.961. There were no significant differences in diagnostic accuracy between ACE-III and MoCA.ConclusionThe present findings support that both ACE-III and MoCA are useful for detecting MCI in early stages.

Systemic inflammation in traumatic brain injury predicts poor cognitive function

“…The Mini‐Mental State Examination (MMSE) and MoCA are widespread and concise screening tools for the assessment of cognitive impairment that has a significant impact on the evaluation of age‐related cognitive decline 20 . Recently, the MoCA has been developed to detect mild cognitive impairment with a score range 0–30 in China and other countries 21–23 . In addition, MoCA can address orientation, drawing figures, processing speed, naming objects, memory, recall, attention, vigilance, repetition, verbal fluency, and abstraction 24 .…”

<p>Comparative Diagnostic Accuracy Of ACE-III And MoCA For Detecting Mild Cognitive Impairment: A Letter To The Editor [Letter]</p>

“…The authors recruited 120 patients with MCI, and 136 healthy controls, and showed a positive correlation between ACE-III results and other common cognitive assessment methods (Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE)). They also showed ACE-III to have higher diagnostic accuracy in detecting MCI when compared with the MMSE 1. We would like to thank the authors for highlighting the success of the Chinese version of ACE-III in diagnosing MCI and would like to offer some comments regarding their study.…”

“…One review also states age to be a consideration, with people over 75 scoring less in comparison with younger people 4. Wang et al show significant differences in age and education level in their study, with patients in the MCI group being, on average, 7.5 years older and 4.0 years more educated than their control counterparts 1. We agree with the authors that any further studies about the Chinese version of ACE-III should take education level into consideration, to avoid any bias due to patient population.…”

Peripheral levels of sST2 are increased in patients with temporal lobe epilepsy: Additional evidence of low-grade inflammation

“…Twelve patients were also evaluated through the Adenbrooke's Cognitive Examination Revised (ACE-R). The ACE-R provides evaluation of six cognitive domains (orientation, attention, memory, verbal fluency, language, and visual ability) and is useful to detect mild cognitive impairment [29,30].…”