<p>Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne</p>

Abstract

Background: Acne is a frequent adolescent disease characterized by inflammatory and noninflammatory lesions whose topical treatment very often presents adverse phenomena such as irritation or resistance to antibiotics that reduce the patient's compliance. The purpose of this study is to compare a commercial product (Acnatac gel) based on clindamycin-tretinoin (CTG) with a galenic compound containing 2 essential oils (Myrtus communisL. and Origanum vulgare) and tretinoin (MOTC) to evaluate its anti-acne effectiveness and action on the microclimate of the skin. Methods: Sixty volunteers were randomly divided into an A group using MOTC and a B group, as a positive control, using CTG. The effectiveness was assessed with non-invasive skin analysis (Sebumeter, pH meter, Tewameter and Mexameter) and the counts of the number of lesions, after 15 and 30 days. Results: In both groups, there is a worsening of transepidermal water loss (TEWL) due to tretinoin. MOTC has improved, starting from 15 days of treatment, the papular erythema (p = 0.0329 vs CTG) and has reduced at all times even the rashes of retinoids present in the healthy perilesional skin (p = 0.0329 and p = 0.0017, respectively, at 15 and 30 days). Conclusion: MOTC has shown, compared to Acnatac, to have anti-acne efficacy and to possess an anti-inflammatory activity, due to essential oils, able to reduce in vivo erythematous lesions and those induced by retinoids.

Correlation Between Facial Skin Microbiota and Skin Barriers in a Chinese Female Population with Sensitive Skin

“…Previous clinical studies have demonstrated that plant-derived ingredients or oils remarkably improve inflammatory skin disorders, including acne. 29 , 30 However, whether the ingredients of the skin care products improve the rash in patients with acne through altering the skin microbiota remains unknown until now, which deserves further investigations.…”

<p>Methicillin-Resistant <em>Staphylococcus aureus</em> (MRSA): One Health Perspective Approach to the Bacterium Epidemiology, Virulence Factors, Antibiotic-Resistance, and Zoonotic Impact</p>

“…102,103 Besides, therapies of natural origin should be implemented especially in dermal infections such as a combination of propolis, tea tree oil, and Aloe vera and the combination of Myrtus communisL., Origanum vulgare and tretinoin (MOTC). 104,105 The spontaneous use of broad-spectrum antibiotics in the treatment of MRSA infection must be prohibited, and the ideal treatment should base on the eminent results of the antibiotic sensitivity test. 106,107 New antibiotics are thought to be more effective against MRSA infections such as telavancin and tedizolid.…”

Essential Oils as Natural Sources of Fragrance Compounds for Cosmetics and Cosmeceuticals

“…Hence conveniently, added essential oils are able to enhance the dermato-cosmetic properties of the final product, not only by protecting against microbial infections but also contributing to the preservation of the cosmetic formulation [ 15 , 16 ]. Interestingly, they are also used to induce additional benefits to the skin such as anti-acne, anti-aging, skin lightening, and sun protection, among others, in cosmeceutical products, thus rendering them highly valuable to cosmetic industries [ 17 , 18 , 19 , 20 , 21 , 22 ].…”