<p>Bucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation</p>

Abstract

Objective: To formulate and assess bucco-adhesive films of propranolol hydrochloride for pediatric use. Methods: Different films were formulated adopting mucin, polyvinyl alcohol, chitosan and carbopol. A drug/polymer compatibility study was conducted adopting differential scanning calorimetry and Fourier transform infrared spectroscopy. The prepared films were physically investigated for variation of weight, propranolol content, thickness, surface pH, proportion of moisture, folding endurance and mucoadhesion. In vitro drug release study and kinetic analysis of the corresponding data have been conducted. The optimized formulation was selected for a bioavailability study using albino rabbits and adopting a developed HPLC method. The pharmacokinetic parameters of the drug were calculated following administration of the optimized film and the corresponding marketed oral tablets to albino rabbits. Key Finding: The compatibility study revealed the absence of drug/polymer interaction. The film formulations had suitable mucoadhesive and mechanical properties. The optimized formulation exhibited reasonable drug release that followed Higuchi diffusion pattern. The calculated AUC0-8h presented an enhancement in the bioavailability of propranolol hydrochloride from the selected film formulation by 1.9 times relative to the marketed propranolol oral tablets. Conclusion: These findings support that propranolol hydrochloride bucco-adhesive film can be considered as a proper effective dosage form for pediatric delivery.

Oromucosal Alginate Films with Zein Nanoparticles as a Novel Delivery System for Digoxin

“…In terms of the swelling profile, there are no significant differences for both formulations (Figure 6). These formulations demonstrated an increase in the swelling capability after 30 s, suggesting a suitable film swelling, able to accelerate the release of the drug by diffusion and erosion [92]. Drug-loaded films dissolved significantly slower (p = 0.02) than the equivalent drug-free formulation (Table 5).…”

“…after 30 s, suggesting a suitable film swelling, able to accelerate the release of the drug by diffusion and erosion [92]. Drug-loaded films dissolved significantly slower (p = 0.02) than the equivalent drug-free formulation (Table 5).…”

Anti-otomycotic potential of nanoparticles ofMoringa oleiferaleaf extract: an integratedin vitro,in silicoand phase 0 clinical study

“…The in vitro release profile of both the Moringa extract and its formulated giant nanoparticles (M/NPs) was assessed via the dialysis membrane method, where Tween-80 0.5% (w/v) in phosphate buffered saline (PBS, pH 7.4) was adjusted as the release medium. 17 A dialysis bag (MWCO cut-off 8–12 kDa) containing M/NPs (1 mL) was immersed in 100 mL of release medium at 37 °C on a shaker at 100 rpm. Aliquots of the release medium (1 mL) were withdrawn and an equal volume of fresh release medium was added at determined time points.…”

“…The accumulative released percentage of the extract was determined by UV, where each sample analysis was performed in triplicate. 17 The release kinetics of the extract from the MENPs were studied using different mathematical modelling such as diffusion, 18 dissolution, 19 swelling, 20 erosion, 21 precipitation and/or degradation. 22 2.4.6.…”

The Potential of Corchorus olitorius Seeds Buccal Films for Treatment of Recurrent Minor Aphthous Ulcerations in Human Volunteers

“…Buccal and mucoadhesive films are among the dosage forms that adhere well to different patient categories. Adults, children, or the elderly can easily self-administer buccoadhesive film and manage their doses [ 1 , 2 ]. The casting of hydrophilic polymer dispersions is the most common method of buccoadhesive film preparation [ 1 , 2 , 3 ].…”