<p>Atypical Palmar Involvement with Erythema Elevatum Diutinum as a Sole Manifestation: A Report of Two Cases</p>

Abstract

Erythema elevated diutinum (EED) is a rare distinctive form of cutaneous leukocytoclastic vasculitis. EED typically presents with asymptomatic symmetrical erythematous-brown papules, nodules or plaques which favor the extensor aspect of extremities while distinctly sparing the palms. We report two cases of EED with a rare presentation limited to the palms.

Keratotic plaques on the hands

“…The etiology is unclear: it may arise from vascular mediated immune complex deposition, which activates the inflammatory cascade [1]. Erythema elevatum diutinum has been reported to be associated with multiple underlying systemic conditions including infections (streptococcal infection, HIV, hepatitis B and C virus) [2][3][4], autoimmune disorders (rheumatoid arthritis, lupus erythematosus) [5], chronic inflammatory bowel diseases [6] and hematological malignancies (particularly IgA monoclonal gammopathy) [7]. However, no underlying disease was detected in this patient.…”

Palmar nodules in a young woman with ulcerative colitis and enteropathic arthritis

“…Clinically, it consists of symmetrical erythematous to purple nodules and plaques with a predilection for the extensor surfaces overlying joints, particularly hands, feet, elbows, and knees. To date, palmar involvement has been reported only in a few patients 1–5 . Lesions are mostly asymptomatic, although some patients can experience pruritus, tenderness, and a burning sensation after the onset of new lesions 1 …”

“…To date, palmar involvement has been reported only in a few patients. [1][2][3][4][5] Lesions are mostly asymptomatic, although some patients can experience pruritus, tenderness, and a burning sensation after the onset of new lesions. 1 In our patient, the differential diagnosis included palmar involvement by subcutaneous granuloma annulare (SGA) and rheumatoid nodules (RN).…”

Dynamic Topic Modelling for Exploring the Scientific Literature on Coronavirus: An Unsupervised Labelling Technique

“…The rest of the evolution can be observed in the table. Among the most representative documents on this topic, we find clinical reports of cases of diseases (some painful) in patients [45], [46], [47].…”