<p>Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study</p>

Abstract

BackgroundTo investigate the association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus (T2DM) at a tertiary care hospital in Jeddah, Saudi Arabia (SA).MethodsThe present retrospective cross-sectional study was accomplished at the Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, SA, between April and July 2018. There were 206 T2DM patients selected for the study (141 females and 65 males), and the data were collected through a review of the electronic profiles of patients by using the medical electronic file system used at the KAU Hospital. Biochemical data such as fasting plasma glucose (FPG), HbA1c and lipid profile, along with the patient’s age, BMI and gender, were also taken from the electronic file system. The inclusion criteria allowed for only patients who were regularly seeing their physician and whose electronic file was up to date.ResultsThe participants’ data were analyzed gender-wise. The females had significantly higher values for BMI (p=0.002), HbA1c (p=0.009), triglycerides (TGs) (p<0.001), high-density lipoprotein cholesterol (HDL-C) (p=0.002) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) compared to the males. The study subjects were grouped according to their level of HbA1c (good glycemic index <7%, and poor glycemic index >7%). In both groups, no significant differences were found in any of the parameters other than TGs (p=0.020) and HbA1c (p<0.001). An analysis of the correlation between HbA1c and other parameters exhibited a significant correlation with TG (r=0.16, p=0.020), while no significant relationship was observed with the other variables. The linear regression results indicated that HbA1c values were associated with TGs (p=0.020) and were independent of age, BMI, TC, LDL-C, HDL-C and FPG levels.ConclusionThe glycated Hb was associated with TGs, and no significant association was found with age, BMI, TC, LDL-C, HDL-C and FPG levels.

Blood pressure, lipid profile and glycemic control among type-2 diabetic patients in North Kerala

“…13,15,16 However, Alzahrani et al and a few other studies reported a statistically non-significant negative link between HbA1c and HDL. 11,12,17 The present study found no relationship between HbA1c and LDL. Similar result reported in some studies, but there are studies inconsistent with the result which stated significant correlation between HbA1c and LDL.…”

“…Similar result reported in some studies, but there are studies inconsistent with the result which stated significant correlation between HbA1c and LDL. 11,13,[16][17][18] In the present study, T2DM patients in the group HbA1c ≥7% had significantly higher values of FBS, HbA1c, TG, TG/HDL levels compared to DM2 patients in DM2 HbA1c <7% group. These parameters showed a highly significant positive correlation in poor glycemic group with p≤0.00001.…”

Real life experience of apremilast in psoriasis and arthritis psoriatic patients: Preliminary results on metabolic biomarkers

“…The HbA1c level, although it represents a standard test for monitoring metabolic control, is not generally recommended for psoriatic patients in dermatological clinical practice. However, because HbA1c level reflects not only the glucose but also the lipid profile, 24 the reduction of these metabolic parameters in our patients, induced by apremilast, could be correlated to a decrease of HbA1c level. Altogether, these results suggest that this drug, by attenuating the systemic inflammatory state through the cAMP‐dependent PDE4 inhibition, may improve metabolic diseases associated with PsA.…”

TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

“…In diabetic subjects, insulin resistance has been considered the reason for dyslipidemia. The causes for increased triglycerides levels in diabetic patients is an insu cient function or secretion of insulin that causes higher hepatic secretion of VLDL together with the late elimination of TG-rich lipoproteins, mostly due to greater substrate levels for TG synthesis [17].…”