TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

Aboelkhair, Noran Talaat; Kasem, Heba Elsayed; Abdelmoaty, Amera Anwar; El-Edel, Rawhia H

doi:10.1007/s11033-021-06537-0

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Also, TT and CT genotypes were significantly increased in the T2DM without complications and T2DM with complications groups. [ 27 ] The same is also evidenced by Nanfa et al . [ 28 ] and Demirsoy et al ,[ 29 ] who have reported that the T allele at rs7903146 is related to the risk of T2DM.…”

Section: Discussionsupporting

confidence: 77%

Association of TCF7L2 Variants in Type 2 Diabetes Mellitus with Hypertriglyceridemia – A Case-Control Study

Gunavathy,

Balaji,

Kumaravel

2023

Indian Journal of Endocrinology and Metabolism

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Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition involving various genetic and environmental factors leading to impaired insulin secretion, resulting in hyperglycemia. The transcription factor 7-like 2 (TCF7L2) gene is an element of the Wnt signaling pathway that plays an important role in glucose and lipid metabolism. The aim of this study is to evaluate the association of TCF7L2 rs7903146 and rs12255372 polymorphisms in T2DM with hypertriglyceridemia. Methods: We investigated the effect of rs7903146 and rs12255372 on T2DM with high triglyceride (TG) levels in 60 patients and 20 controls. The anthropometric measurements and biochemical tests were assessed. Peripheral blood samples were collected, and genomic DNA was extracted. The genotyping of TCF7L2 polymorphisms was carried out using polymerase chain reaction (PCR)-based direct sequencing and allele-specific PCR methods. The T2DM patients and controls were compared by means of the t-test, Chi-square test, odds ratio (OR), and 95% confidence interval (CI) using Epi Info v7. Results: The HbA1c was found to be 9.7 ± 2.1 and 5.4 ± 0.5% in patients and controls, respectively. The average TG levels (P < 0.005) in patients were 205.2 ± 145.7 and 106.4 ± 27.4mg/dl in controls. Significant evidence of association was found in T2DM patients having high TG levels with rs7903146 CT/TT (OR: 4.89; P = 0.0105) and rs12255372 GT/TT (OR: 5.23; P = 0.0101) genotypes when compared to controls. Conclusion: The results of this study show that TCF7L2 rs7903146 CT/TT and rs12255372 GT/TT genotypes are significantly associated with the risk of hypertriglyceridemia in individuals with T2DM among the studied population.

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Section: Discussionsupporting

confidence: 77%

Association of TCF7L2 Variants in Type 2 Diabetes Mellitus with Hypertriglyceridemia – A Case-Control Study

Gunavathy,

Balaji,

Kumaravel

2023

Indian Journal of Endocrinology and Metabolism

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“…T2DM has become one of the serious public health problems. T2DM is the result of the interaction between genetic and environmental factors, a large number of studies have revealed that multiple single nucleotide polymorphisms (SNPs) are related to the development of T2DM [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population

Wang

Yan

et al. 2022

BMC Cardiovasc Disord

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Background PCSK9 gene expression is associated with biological processes such as lipid metabolism, glucose metabolism, and inflammation. In the present study, our primary objective was to assess the association between the single-nucleotide polymorphisms in the PCSK9 gene and type 2 diabetes in Uygur subjects, in Xinjiang, China. Methods We designed a case–control study including 662 patients diagnosed with T2DM and 1220 control subjects. Four single-nucleotide polymorphisms (rs11583680, rs2483205, rs2495477 and rs562556) of PCSK9 gene were genotyped using the improved multiplex ligation detection reaction technique. Results For rs2483205, the distribution of genotypes, dominant model (CC vs CT + TT), overdominant model (CC + TT vs CT) showed significant differences between T2DM patients and the controls (P = 0.011 and P = 0.041 respectively). For rs2495477, the distribution of genotypes, the dominant model (AA vs GA + GG) showed significant differences between T2DM patients and the controls (P = 0.024). Logistic regression analysis suggested after adjustment of other confounders, the differences remained significant between the two groups [for rs2483205 CC vs CT + TT: odds ratio (OR) = 1.321, 95% confidence interval (CI) 1.078–1.617, P = 0.007; CC + TT vs CT: OR = 1.255, 95% CI 1.021–1.542, P = 0.03; for rs2495477 AA vs GA + GG: OR = 1.297, 95% CI 1.060–1.588, P = 0.012]. Conclusion The present study indicated that CT + TT genotype and CT genotype of rs2483205, as well as GA + GG genotype of rs2495477 in PCSK9 gene were associated with an increased risk of type 2 diabetes in the Uygur population in Xinjiang.

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Metastatic colorectal cancer and type 2 diabetes: prognostic and genetic interactions

Ottaiano

Circelli²,

Santorsola

et al. 2021

Molecular Oncology

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The present study was undertaken to analyze prognostic and genetic interactions between type 2 diabetes and metastatic colorectal cancer. Patients’ survival was depicted through the Kaplan–Meier product limit method. Prognostic factors were examined through the Cox proportional‐hazards regression model, and associations between diabetes and clinical‐pathologic variables were evaluated by the χ2 test. In total, 203 metastatic colorectal cancer patients were enrolled. Lymph nodes (P = 0.0004) and distant organs (> 2 distant sites, P = 0.0451) were more frequently involved in diabetic patients compared with those without diabetes. Diabetes had an independent statistically significant negative prognostic value for survival. Highly selected patients with cancer and/or diabetes as their only illness(es) were divided into three groups: (a) seven oligo‐metastatic patients without diabetes, (b) 10 poly‐metastatic patients without diabetes, and (c) 12 poly‐metastatic diabetic patients. These groups of patients were genetically characterized through the Illumina NovaSeq 6000 (San Diego, CA, USA) platform and TruSigt™Oncology 500 kit, focusing on genes involved in diabetes and colorectal cancer. Gene variants associated with diabetes and cancer were more frequent in patients in group 3. We found that type 2 diabetes is a negative prognostic factor for survival in colorectal cancer. Diabetes‐associated gene variants could concur with malignancy, providing a rational basis for innovative models of tumor progression and therapy.

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TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

Cited by 6 publications

References 26 publications

Association of TCF7L2 Variants in Type 2 Diabetes Mellitus with Hypertriglyceridemia – A Case-Control Study

Association of TCF7L2 Variants in Type 2 Diabetes Mellitus with Hypertriglyceridemia – A Case-Control Study

Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population

Metastatic colorectal cancer and type 2 diabetes: prognostic and genetic interactions

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