<p>Association Between Bone Mineral Density and Lipid Profile in Chinese Women</p>

Abstract

Atherosclerotic cardiovascular disease may share the risk factors for low bone mineral density (BMD), one of which is dyslipidemia. The association between serum cholesterol and BMD remains controversial. Thus, the correlation between serum lipids and BMD in women was explored in the current study. Materials and Methods: This cross-sectional study included 1116 Chinese female participants. Serum samples were collected to evaluate total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and other laboratory markers. Dual-energy X-ray absorptiometry was used to assess lumbar spine, femoral neck, and total hip BMD. Results: In the postmenopausal women, a non-linear relationship was detected between TC, LDL-C, HDL-C, and lumbar spine BMD. Using segmented linear regression, the inflection points were 5.86 mmol/L, 3.52 mmol/L, and 2.37 mmol/L, respectively. To the left of the inflection point, the higher the serum lipid level, the lower the value for lumbar spine BMD. To the right of the inflection point, the higher the serum level of TC and LDL-C, the higher the value for lumbar spine BMD. In the premenopausal women, the association between HDL-C and femoral neck BMD was non-linear. In addition, LDL-C had a positive association with BMD of the femoral neck and HDL-C had an inverse association with BMD of the femoral neck in postmenopausal women. Conclusion: In postmenopausal women, the relationship between TC, LDL-C, HDL-C, and lumbar spine BMD was non-linear. TC, LDL-C, and HDL-C were negatively associated with lumbar spine BMD when the values were less than 5.86 mmol/L, 3.52 mmol/L, and 2.37 mmol/L, respectively. The mechanisms of the association were unclear, and further research is warranted to clarify the relationship.

High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

“…For example, in Iranian women, Maghbooli et al found that HDL-C levels displayed an inversely correlation with BMD in postmenopausal women with vitamin D deficiency [ 17 ]. Zhang et al demonstrated that HDL-C exhibited a negative association with BMD in Chinese women above 50 years of age [ 18 ]. Makovey et al observed a modest inverse relationship between hip BMD and HDL-C in postmenopausal women [ 31 ].…”

“…Maghbooli et al found that HDL-C exhibited an inverse correlation with BMD in postmenopausal Iranian women with vitamin D deficiency [ 17 ]. Zhang et al observed that HDL-C displayed a negative correlation with lumbar spine BMD in Chinese women [ 18 ]. Conversely, Cui et al suggested that there was no association between HDL-C levels and BMD values at any sites in pre- and postmenopausal subjects [ 19 ].…”

Hypertension is associated with osteoporosis: a case-control study in Chinese postmenopausal women

“…A survey of Chinese people showed that elevated levels of serum high-density lipoprotein cholesterol (HDL-C) led to higher risk of osteoporosis, but a higher HDL-C level was favourable for cardiovascular diseases [ 41 ]. Another study indicated that femoral neck BMD in postmenopausal women was positively correlated with low-density lipoprotein cholesterol (LDL-C) and negatively correlated with HDL-C [ 42 ]. Some clinical data from other populations also support this view [ 43 – 45 ].…”

High-density Lipoprotein Cholesterol Negatively Correlates with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

“…Maghbooli et al found a negative correlation between HDL-C and BMD in postmenopausal Iranian women with vitamin D de ciency [14]. Zhang et al observed that HDL-C was negatively associated with lumbar spine BMD in Chinese women [15]. Conversely, Cui et al suggested that HDL-C level was not associated with BMD values at any of the sites in pre-and post-menopausal subjects [16].…”

“…Some previous studies also explored the association between HDL-C and BMD[14][15][16][17]. For example,Maghbooli et al found in Iranian women that HDL-C levels were negatively correlated with BMD in postmenopausal women with vitamin D de ciency [14].…”