High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

Abstract

Background Many studies have shown that lipids play important roles in bone metabolism. However, the association between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) is unclear. Therefore, this study aimed to investigate the linear or nonlinear relation between HDL-C levels and BMD and addressed whether the HDL-C levels had the potential values for predicting the risk of osteoporosis or osteopenia. Methods Two researchers independently extracted all information from the National Health and Nutrition Examination Survey (NHANES) database. Participants over 20 years of age with available HDL-C and BMD data were enrolled in the final analysis. The linear relationship between HDL-C levels and BMD was assessed using multivariate linear regression models. Moreover, the nonlinear relationship was also characterized by fitted smoothing curves and generalized additive models. In addition, the odds ratio (OR) for osteopenia and osteoporosis was evaluated with multiple logistic regression models. Results The weighted multivariable linear regression models demonstrated that HDL-C levels displayed an inverse association with BMD, especially among females and subjects aged 30 to 39 or 50 to 59. Moreover, the nonlinear relationship characterized by smooth curve fittings and generalized additive models suggested that (i) HDL-C levels displayed an inverted U-shaped relationship with BMD among women 30 to 39 or over 60 years of age; (ii) HDL-C levels exhibited a U-shaped association with BMD among women 20 to 29 or 50 to 59 years of age. In addition, females with high HDL levels (62-139 mg/dL) had an increased risk of osteopenia or osteoporosis. Conclusion This study demonstrated that HDL-C levels exhibit an inverse correlation with BMD. Especially in females, clinicians need to be alert to patients with high HDL-C levels, which may indicate an increased risk of osteoporosis or osteopenia. For these patients, close monitoring of BMD and early intervention may be necessary.

Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis

“…Recently, a group of studies has been demonstrated the roles of MetS in the pathological development of OP [ 19 , 20 ]. Analysis of data from the National Health and Nutrition Examination Survey (NHANES) database shows that the levels of high-density lipoprotein cholesterol are negatively associated with BMD, particularly in females [ 21 ]. The important roles of lipid metabolism in bones have been reported.…”

Avaliação da saúde óssea em pacientes com anorexia nervosa e bulimia nervosa

“…The authors suggested that HDL-c levels could be a useful parameter to determine the postmenopausal women whose BMD should be evaluated (D'AMELIO et al, 2008), and this could be further investigated in the ED population. Investigations with data from women between the ages of 20 and 60 years confirmed an inverse U-shaped association between levels of HDL-c and BMD, in which high levels mg/dL), comparable with the ranges found for the AN group in the present study, increased the risk of osteopenia and osteoporosis (TANG et al, 2021).…”

Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis

“…11 Moreover, the subset analyses of the NHANES database showed that high-density lipoprotein cholesterol (HDL-C) is negatively correlated with BMD, suggesting that HDL-C may have potential predictive for bone loss. 9 In addition, the causal relationship blood lipid and BMD is still largely unknown. These inconsistent findings may come from the inclusion for population with different age, gender, physiological state and accompanying diseases, laboratory measurements and questionnaires, and different correction method of confounding factors such as body mass index (BMI) and lifestyles.…”