<p>A comparative experimental study of analgesic activity of a novel non-steroidal anti-inflammatory molecule – zaltoprofen, and a standard drug – piroxicam, using murine models</p>

Abstract

Purpose Pain is an unpleasant sensation, but a protective mechanism of our body. It is the most common medical complaint requiring a visit to a physician. The new non-steroidal anti-inflammatory drug (NSAID) – zaltoprofen, is a preferential COX-2 inhibitor. It also inhibits bradykinin-induced nociceptive responses by blocking the B2 receptor-mediated pathway in the primary sensory neurons. The present study was conducted to evaluate and compare the anti-nociceptive activity of zaltoprofen with a conventional NSAID – piroxicam, in a mouse model of acute pain using hot plate and tail flick tests. Materials and methods Twenty-four adult Swiss albino mice (20–25 g) of either sex were used in this study. Oral zaltoprofen and piroxicam were used as test and standard drugs respectively. Anti-nociceptive activity was evaluated and compared using hot plate and tail flick tests. Results In comparison to the control group (vehicle), zaltoprofen showed a significant increase in reaction time at various time periods in the hot plate and tail flick tests. In the hot plate method, zaltoprofen groups (15 and 20 mg/kg) showed a significant elevation in pain threshold in comparison to control group (vehicle) ( p <0.001). In the tail flick model also, zaltoprofen groups (15 and 20 mg/kg) showed a significant increase in the reaction time in comparison to control group (vehicle). In both the analgesiometer assays, zaltoprofen was found to be non-inferior compared to a standard drug – piroxicam (positive control). Conclusion Our study concludes that zaltoprofen is an effective analgesic agent in various pain models. Our results support that zaltoprofen has therapeutic potential for treating pain disorders and is non-inferior to a standard drug – piroxicam.

New ibuprofen derivatives with thiazolidin-4-one scaffold with improved pharmaco-toxicological profile

“…The tail-ick assay is a pain receptive model which measures animal nociceptive response latencies to thermal stimulus, based mainly on spinal response [25]. It is known that the response to pain and the reaction time to painful stimulus are mediated at the central nervous system level, and more speci c, at the spinal level [26].…”

Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects

“…This induces oxidative tissue damage, which seems to play an important role in the pathophysiology of NSAID-induced ulceration [38]. Prostaglandins E2 and I2 act in the synthesis of mucus and bicarbonate, in the regulation of acid secretion and blood flow of the gastric mucosa, and their inhibition critically compromises gastric cytoprotection [39]. NSAIDs, such as piroxicam, can produce gastric lesions in humans and experimental animals.…”

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

“…The pain is induced to the animals by placing the animals on hot-plate and temperature is maintained within 55 ± 0.5 °C range. 18 The response to a pain stimulus is indicated by paw licking or jumping off the plate. The response time is recorded for each group at 0, 30, 60, 120, and 180 minutes throughout the observation period.…”