The aim of the study was to evaluate the generalizability of the minority stress model on predicting depressive symptomatology among sexual minority men living outside of the United States. In addition, the role of resilience and its relationship between individual minority stressors and depressive symptomatology is examined. The study utilized online purposive sampling and focused on sexual minority men living in Brazil; participants’ (N = 388) ages ranged from 18 to 56 years (Mage = 25.31, SDage = 7.87, Mdnage = 23). Participants completed measures that assessed sociodemographics, minority stressors, resilience, and symptoms of depression. Results of a hierarchical regression indicated that, while accounting for sociodemographics, enacted stigma and internalized homonegativity independently predicted participants’ depressive symptomatology, whereas concealment of sexual identity did not. Further, to assess the role of resilience, while accounting for the effects of sociodemographics and minority stressors, results suggested that resilience significantly added to predicting depressive symptomatology and indicated that enacted stigma was the only minority stressor that significantly predicted depressive symptomatology. Lastly, when interactions between individual minority stressors and resilience were added to the model, results suggested that resilience moderated the relationship between concealment of sexual orientation and depressive symptomatology. The study’s findings highlight the importance of considering sociocultural context and resilience in evaluating minority stress and depressive symptomatology among sexual minorities. The authors discuss the implications of this study in the context of theory, research, clinical practice, and policy among sexual minority men.