&lt;I&gt;Staphylococcus epidermidis&lt;/I&gt; device-related infections: pathogenesis and clinical management

McCann, Maureen; Gilmore, Brendan; Gorman, Seán

doi:10.1211/jpp/60.12.0001

Cited by 135 publications

(78 citation statements)

References 178 publications

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“…Various studies show that the presence of biofilms causes a reduction in antibiotic penetration into the cell [29,30] and an increase in resistance gene expression. Biofilms can provide an appropriate environment for transmitting drug resistance plasmids [31,32]. The findings of the present study show that 94.1% of slime-producing S. epidermidis isolates are multi-drug resistant, thus supporting the contribution of slime to the emergence of antibiotic resistance.…”

Section: Discussionsupporting

confidence: 57%

Slime layer formation and the prevalence of mecA and aap genes in Staphylococcus epidermidis isolates

Pourmand

Abdossamadi

Salari

et al. 2010

J Infect Dev Ctries

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Introduction: Staphylococcus epidermidis strains are frequently associated with catheter-related infection, acute bacteremia, and hospitalacquired infection. Some isolates produce an extracellular matrix called slime that may make them more resistant to antibiotics. The aim of this study was to determine antimicrobial resistance patterns, the prevalence of slime production, and the distribution of genes (mecA and aap, respectively) associated with these phenotypes in S. epidermidis nasal isolates from health-care personnel. Methodology: A descriptive cross-sectional study was performed on 163 nasal swabs from health-care staff (one swab per subject). S. epidermidis isolates were tested for slime production on congo red agar and antibiotic resistance. PCR-based screening for mecA and aap genes was performed upon the extracted DNA of S. epidermidis isolates. Results: A total of 99 S. epidermidis strains were cultured from 58.9% of the study participants (n = 96). Of these strains, 34 (34.3%) isolates produced slime. A significant relation between slime production and resistance to penicillin 32(94%) , oxacillin 30(88%),, tetracycline 20(59%), erythromycin 27(79%), and clindamycin 26(77%) was found. Respectively, 95.8% and 94.8% of all isolates were PCR-positive for mecA and aap, but only 59.8% of mecA+ strains were oxacillin-resistant and 37.3% of aap+ strains were slime producers. Conclusions: The surveillance of nasal colonization with slime-forming oxacillin-resistant S. epidermidis in health-care workers might be helpful in breaking the epidemiological chain of hospital-acquired infections.

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Section: Discussionsupporting

confidence: 57%

Slime layer formation and the prevalence of mecA and aap genes in Staphylococcus epidermidis isolates

Pourmand

Abdossamadi

Salari

et al. 2010

J Infect Dev Ctries

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“…Unfortunately, despite advances in surgical techniques and prophylactic systemic antibiotics, these abiotic surfaces are prone to bacterial infections mostly caused by Staphylococcus aureus and Staphylococcus epidermidis (1,2). Early bacterial colonization of the medical device surface may take place in the first 6-h postoperative "decisive period" with adherence of biofilm matrix (1).…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

et al. 2014

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Abstract. A new vancomycin (VCM)-eluting mixed bilayer niosome formulation was evaluated for the control of staphylococcal colonization and biofilm formation on abiotic surfaces, a niosome application not explored to date. Cosurfactant niosomes were prepared using a Span 60/Tween 40/cholesterol blend (1: 1: 2). Tween 40, a polyethoxylated amphiphile, was included to enhance VCM entrapment and confer niosomal surface properties precluding bacterial adhesion. VCM-eluting niosomes showed good quality attributes including relatively high entrapment efficiency (∼50%), association of Tween 40 with vesicles in a constant proportion (∼87%), biphasic release profile suitable for inhibiting early bacterial colonization, and long-term stability at 4°C for a 12-month study period. Niosomes significantly enhanced VCM activity against planktonic bacteria of nine staphylococcal strains. Using microtiter plates as abiotic surface, VCM-eluting niosomes proved superior to VCM in inhibiting biofilm formation, eradicating surface-borne biofilms, inhibiting biofilm growth, and interfering with biofilm induction by VCM subminimal inhibitory concentrations. Data suggest dual functionality of cosurfactant VCM-eluting niosomes as passive colonization inhibiting barrier and active antimicrobial-controlled delivery system, two functions recognized in infection control of abiotic surfaces and medical devices.

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“…8 The bacterial infection be able cause a human diseases. 9 Transcutaneous infection from these bacteria has potential as beginning bacterial entry into the body, and the subsequent induce local or systemic infection. 10 The survey showed that >40% of S. epidermidis infections occur in the circulatory system, whereas S. aureus infection <20%.…”

Section: Introductionmentioning

confidence: 99%

Efficcacy of Lantana camara Linn. leaf extracts ointment on dermal wound healing were infected with Staphylococcus epidermidis

Parwanto

2017

Int J Basic Clin Pharmacol

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Background: Dermal infections by Staphylococcus epidermidis can cause problems for patients. Antibiotic resistance have been reported to treat the bacteria, therefore need to develop new drugs, among others sourced from herbs. For this purpose, study is needed to find an efficacy of Lantana camara Linn. leaf extract ointment on dermal wound healing were infected with S. epidermidis.Methods: Wistar rats divided into 4 groups randomly. Group I=dermal wounded, infected with S. epidermidis, untreated. Group II=dermal wounded, infected with S. epidermidis, treated with L. camara Linn. leaf extract ointment 5%. Group III=dermal wounded, infected with S. epidermidis, treated with L. camara Linn. leaf extract ointment 10%. Group IV=dermal wounded, infected with S. epidermidis, treated with sodium fusidate 2%. Bacterial colonies number observed on 6 days, while the quality of wound healing, measurement of DNA and protein levels on 6, 14 and 18 days. Mean ± SD between groups were analyzed by ANOVA.Results: Wound healing in group II qualitatively better than group I, III and IV. Bacterial colonies number in group II was lower than groups I, III and IV (p<0.05), whereas DNA and protein levels was higher in group II compare to groups I, III and IV (p<0.05). On 6, 14 and 18 days observations there are trend similarly ie DNA levels decreased, conversely protein levels increased.Conclusions: L. camara Linn. leaf extract ointment 5% more effective than 10% on dermal wound healing.

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<I>Staphylococcus epidermidis</I> device-related infections: pathogenesis and clinical management

Cited by 135 publications

References 178 publications

Slime layer formation and the prevalence of mecA and aap genes in Staphylococcus epidermidis isolates

Slime layer formation and the prevalence of mecA and aap genes in Staphylococcus epidermidis isolates

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

Efficcacy of Lantana camara Linn. leaf extracts ointment on dermal wound healing were infected with Staphylococcus epidermidis

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